$129 Cheap Flights from Panama City (ECP) to Louisville (SDF)

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Find available prices by choosing your travel dates.

Cheap Flights from Panama City to Louisville (ECP-SDF)

Prices were available within the past 7 days and start at $129 for one-way flights and $257 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
United
Southwest Airlines
American Airlines
United
Southwest Airlines
United
American Airlines
Southwest Airlines
Delta
Flights from Panama City (ECP) to Louisville (SDF)
Origin airport
Northwest Florida Beaches Intl.
Destination airport
Louisville Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$256
Distance
541 mi

Panama City to Louisville Flights

The cheapest times to fly from Panama City to Louisville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Louisville are during the month of July. You can find some of the cheapest flights from Panama City to Louisville with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Panama City to Louisville

Sunday is one of the best days to book for cheap flights from Panama City to Louisville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Panama City to Louisville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Louisville in 2025. You can also book with separate airlines for your outbound and return journeys, from $129 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Louisville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to Louisville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

Is it cheaper to buy a plane ticket from Northwest Florida Beaches Intl. Airport to Louisville Muhammad Ali Intl. Airport last minute?
Being spontaneous is an amazing way to travel around, but it isn’t necessarily the best method to nab a bargain plane ticket. Consider booking your Northwest Florida Beaches Intl. Airport to SDF journey in advance instead of leaving it until the last minute. Based on flight pricing and demand studies in 2022, we have found that the best time to book domestic flights is between 28 – 35 days ahead of the departure date, and international flights three to four months in advance. Leave your spontaneous side for when you get to your destination!
What airports do you fly into for Louisville from Panama City?
Louisville Intl. Airport (SDF), Bowman Field Airport (LOU) and Bardstown, KY (BRY-Samuels Field) are your options when jetting from Panama City to Louisville. Roughly 5 mi south of downtown Louisville, Louisville Intl. Airport (SDF) is the city’s main entry point. Consider things such as flight arrival and departure times and the distance to your hotel before deciding where you fly into. Churchill Downs and KFC Yum Center are a couple of top attractions to put on your must-see list when you arrive.
Can I change the date of my flight from ECP to Louisville Muhammad Ali Intl. Airport?
Sometimes life gets in the way of plans, so Expedia is here to help make things as simple as possible. To start, find your ECP to Louisville Muhammad Ali Intl. Airport itinerary through the Expedia Trips portal and look up the fare rules and restrictions to see if change fees apply. If you booked in the last 24 hours, some carriers will let you cancel for free and organize new flights. If you booked your fare more than 24 hours ago, connect with us via our Customer Service portal to learn more about your options.

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