$144 Cheap Flights from Panama City (ECP) to San Diego (SAN)

View $144 flight on Sun, May 25, 2025Opens in a new window

Popular airlines from Northwest Florida Beaches Intl. Airport (ECP) to San Diego Intl. Airport (SAN)

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Find available prices by choosing your travel dates.

Cheap Flights from Panama City to San Diego (ECP-SAN)

Prices were available within the past 7 days and start at $144 for one-way flights and $307 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, May 27 - Tue, Jun 3
ECP
Panama City
SAN
San Diego
$307 Roundtrip, found 6 hours ago
$307
Roundtrip
found 6 hours ago
Select Delta flight, departing Tue, May 27 from Panama City to San Diego, returning Tue, Jun 3, priced at $307 found 6 hours ago
Southwest Airlines
Tue, May 20 - Sun, May 25
ECP
Panama City
SAN
San Diego
$307 Roundtrip, found 22 hours ago
$307
Roundtrip
found 22 hours ago
Select Southwest Airlines flight, departing Tue, May 20 from Panama City to San Diego, returning Sun, May 25, priced at $307 found 22 hours ago
American Airlines
Tue, May 20 - Sun, May 25
ECP
Panama City
SAN
San Diego
$312 Roundtrip, found 22 hours ago
$312
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Tue, May 20 from Panama City to San Diego, returning Sun, May 25, priced at $312 found 22 hours ago
United
Tue, May 20 - Sun, May 25
ECP
Panama City
SAN
San Diego
$312 Roundtrip, found 22 hours ago
$312
Roundtrip
found 22 hours ago
Select United flight, departing Tue, May 20 from Panama City to San Diego, returning Sun, May 25, priced at $312 found 22 hours ago
United
Tue, May 20 - Sun, May 25
ECP
Panama City
SAN
San Diego
$317 Roundtrip, found 22 hours ago
$317
Roundtrip
found 22 hours ago
Select United flight, departing Tue, May 20 from Panama City to San Diego, returning Sun, May 25, priced at $317 found 22 hours ago
Delta
Thu, May 15 - Tue, May 20
ECP
Panama City
SAN
San Diego
$325 Roundtrip, found 4 hours ago
$325
Roundtrip
found 4 hours ago
Select Delta flight, departing Thu, May 15 from Panama City to San Diego, returning Tue, May 20, priced at $325 found 4 hours ago
Delta
Fri, May 30 - Tue, Jun 3
ECP
Panama City
SAN
San Diego
$327 Roundtrip, found 6 hours ago
$327
Roundtrip
found 6 hours ago
Select Delta flight, departing Fri, May 30 from Panama City to San Diego, returning Tue, Jun 3, priced at $327 found 6 hours ago
American Airlines
Wed, Jun 25 - Fri, Jul 4
ECP
Panama City
SAN
San Diego
$330 Roundtrip, found 8 hours ago
$330
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Wed, Jun 25 from Panama City to San Diego, returning Fri, Jul 4, priced at $330 found 8 hours ago
American Airlines
Thu, Jun 26 - Sat, Jul 5
ECP
Panama City
SAN
San Diego
$330 Roundtrip, found 8 hours ago
$330
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Thu, Jun 26 from Panama City to San Diego, returning Sat, Jul 5, priced at $330 found 8 hours ago
American Airlines
Wed, Jun 4 - Sat, Jun 7
ECP
Panama City
SAN
San Diego
$332 Roundtrip, found 7 hours ago
$332
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Wed, Jun 4 from Panama City to San Diego, returning Sat, Jun 7, priced at $332 found 7 hours ago
Flights from Panama City (ECP) to San Diego (SAN)
Origin airport
Northwest Florida Beaches Intl.
Destination airport
San Diego Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$306
Distance
1849 mi

Panama City to San Diego Flights

The cheapest times to fly from Panama City to San Diego

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to San Diego are during the month of May. You can find some of the cheapest flights from Panama City to San Diego with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Panama City to San Diego

Sunday is one of the best days to book for cheap flights from Panama City to San Diego: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Panama City to San Diego

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to San Diego in 2025. You can also book with separate airlines for your outbound and return journeys, from $144 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to San Diego flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to San Diego airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Northwest Florida Beaches Intl. Airport (ECP) to San Diego Intl. Airport (SAN) cost?
Discover the latest flight deals from ECP to SAN by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from ECP to SAN?
The cheapest flights from ECP to SAN are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from ECP to SAN?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from ECP to SAN. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Northwest Florida Beaches Intl. Airport (ECP) to San Diego Intl. Airport (SAN)?
You’ll have to take a flight with a layover if you’re traveling from Northwest Florida Beaches Intl. Airport (ECP) to San Diego Intl. Airport (SAN). There are no daily direct flights on this route. However, just filter your search to include one or two stops to discover the best option for your trip.
What day of the week has the most flights from ECP to SAN?
You’ll typically find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can vary from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Northwest Florida Beaches Intl. Airport (ECP) to San Diego Intl. Airport (SAN)?
To avoid potential delays on the Northwest Florida Beaches Intl. Airport (ECP) to San Diego Intl. Airport (SAN) route, travel before 3 PM. Departures after this hour have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Northwest Florida Beaches Intl. Airport (ECP) to San Diego Intl. Airport (SAN) last-minute?
Holding off until right before your break to book a ticket from ECP to SAN often results in higher prices. Although you may find some last-minute deals, they aren’t always guaranteed. Be flexible with your itinerary to boost your chances of snagging a bargain.
Is it cheaper to book an ECP to SAN flight and hotel package?
You’ll typically save money by booking an ECP to SAN flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it’s simple to manage everything in one convenient place. After selecting your preferred accommodations and flights, consider other add-ons like activities, tours and car rentals.
Can I cancel or change the date of my flight from Northwest Florida Beaches Intl. Airport (ECP) to San Diego Intl. Airport (SAN)?
Generally, it’s possible to cancel or reschedule your ECP to SAN flight. However, for bookings made more than 24 hours ago, additional fees may apply. Check your airline’s policies in your itinerary to see what changes are possible and if any costs are involved. You’ll also find further details on our Customer Service portal.

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*Available to One Key members.