$121 Cheap Flights from Detroit (DTW) to Knoxville (TYS)

View $121 flight on Sun, May 25, 2025Opens in a new window

Popular airlines from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS)

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Find available prices by choosing your travel dates.

Cheap Flights from Detroit to Knoxville (DTW-TYS)

Prices were available within the past 7 days and start at $121 for one-way flights and $230 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Sun, May 25 - Sun, Jun 8
DTW
Detroit
TYS
Knoxville
$230 Roundtrip, found 5 hours ago
$230
Roundtrip
found 5 hours ago
Select Frontier Airlines flight, departing Sun, May 25 from Detroit to Knoxville, returning Sun, Jun 8, priced at $230 found 5 hours ago
Frontier Airlines
Sun, Jun 1 - Thu, Jun 26
DTW
Detroit
TYS
Knoxville
$241 Roundtrip, found 11 hours ago
$241
Roundtrip
found 11 hours ago
Select Frontier Airlines flight, departing Sun, Jun 1 from Detroit to Knoxville, returning Thu, Jun 26, priced at $241 found 11 hours ago
Frontier Airlines
Sun, Aug 3 - Sun, Aug 17
DTW
Detroit
TYS
Knoxville
$252 Roundtrip, found 18 hours ago
$252
Roundtrip
found 18 hours ago
Select Frontier Airlines flight, departing Sun, Aug 3 from Detroit to Knoxville, returning Sun, Aug 17, priced at $252 found 18 hours ago
American Airlines
Wed, May 21 - Sun, May 25
DTW
Detroit
TYS
Knoxville
$291 Roundtrip, found 2 days ago
$291
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, May 21 from Detroit to Knoxville, returning Sun, May 25, priced at $291 found 2 days ago
American Airlines
Sat, May 17 - Tue, May 20
DTW
Detroit
TYS
Knoxville
$299 Roundtrip, found 16 hours ago
$299
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Sat, May 17 from Detroit to Knoxville, returning Tue, May 20, priced at $299 found 16 hours ago
Frontier Airlines
Sun, Jun 8 - Thu, Jun 12
DTW
Detroit
TYS
Knoxville
$301 Roundtrip, found 4 days ago
$301
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Sun, Jun 8 from Detroit to Knoxville, returning Thu, Jun 12, priced at $301 found 4 days ago
Frontier Airlines
Thu, Jun 19 - Thu, Jul 3
DTW
Detroit
TYS
Knoxville
$302 Roundtrip, found 2 hours ago
$302
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Thu, Jun 19 from Detroit to Knoxville, returning Thu, Jul 3, priced at $302 found 2 hours ago
Frontier Airlines
Thu, Jun 5 - Mon, Jun 9
DTW
Detroit
TYS
Knoxville
$310 Roundtrip, found 7 hours ago
$310
Roundtrip
found 7 hours ago
Select Frontier Airlines flight, departing Thu, Jun 5 from Detroit to Knoxville, returning Mon, Jun 9, priced at $310 found 7 hours ago
Delta
Thu, Jul 3 - Thu, Jul 10
DTW
Detroit
TYS
Knoxville
$328 Roundtrip, found 1 day ago
$328
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Jul 3 from Detroit to Knoxville, returning Thu, Jul 10, priced at $328 found 1 day ago
United
Tue, Jun 17 - Mon, Jun 30
DTW
Detroit
TYS
Knoxville
$375 Roundtrip, found 2 hours ago
$375
Roundtrip
found 2 hours ago
Select United flight, departing Tue, Jun 17 from Detroit to Knoxville, returning Mon, Jun 30, priced at $375 found 2 hours ago
Flights from Detroit (DTW) to Knoxville (TYS)
Origin airport
Detroit Metropolitan Wayne County
Destination airport
McGhee Tyson
Airlines serving
American Airlines, Delta, Frontier Airlines, United
Roundtrip price
$230
Distance
444 mi

Detroit to Knoxville Flights

The cheapest times to fly from Detroit to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Detroit to Knoxville are during the month of May. You can find some of the cheapest flights from Detroit to Knoxville with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Detroit to Knoxville

Sunday is one of the best days to book for cheap flights from Detroit to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Detroit to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Detroit to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $121 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Detroit to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Detroit to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS) cost?
Cheap round-trip fares from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS) start at $399. This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a Delta flight leaving DTW on May 16 2025 and touching down at TYS. The price was last updated on April 23 2025 and has not changed since.
What is the cheapest month to fly from DTW to TYS?
The cheapest flights from DTW to TYS are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS)?
Jump on a direct flight with Delta Air Lines and go straight from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS).
What is the cheapest airline that flies from DTW to TYS?
With tickets starting at $249 for a one-way journey from DTW to TYS, Delta is currently the cheapest carrier on this route. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from DTW on July 15 2025. Prices were last updated on April 23 2025 and have not changed since.
How many flights per day from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS)?
On average, there’s only 1 nonstop flight taking off from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS) each day. If this doesn’t suit your schedule, check out flights with layovers. Just customize your search on Expedia to include one or more stops to discover the next best option.
What are the most popular departure times for flights from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS)?
More travelers fly between DTW and TYS at 8 PM than at any other point in the day. Prefer a quieter experience? Travel outside of rush hours and it’s possible you’ll save on your ticket as well.
What day of the week has the most flights from DTW to TYS?
If you fly on a Wednesday, you’ll get the greatest range of options for flights from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS).
What is the earliest flight from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS)?
Detroit Metropolitan Wayne County Airport (DTW)’s earliest flight to McGhee Tyson Airport (TYS) departs at approximately 10:30AM UTC-5. With a flight time of 1h 44m, you’ll touch down at around 12:14PM UTC-5.
How long does it take to fly from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS)?
The average flight time from DTW to TYS is 1 hour and 41 minutes, covering a total distance of 450 mi.
What airline has the least delays from DTW to TYS?
Consider traveling with Delta Air Lines if you’d like to fly straight from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS) without any delays. This carrier has the strongest track record for punctuality, with an on-time score of 85%. Want real-time updates? You can check your flight status using the Expedia App.
What is the best time to fly from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS)?
To avoid possible delays on the Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS) route, fly before 3 PM. Later departures have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
What airports do you fly into for Knoxville from Detroit Metropolitan Wayne County Airport (DTW)?
Browse your flight options from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS). This is the only Knoxville airport you can land at if you’re taking a direct flight.
Is it cheaper to buy a plane ticket from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS) last-minute?
Waiting until right before your break to book a flight from DTW to TYS often results in higher prices. Although you may find some last-minute offers, there’s no guarantee. Allow some flexibility in your schedule for a better chance of getting a bargain.
Is it cheaper to book a DTW to TYS flight and hotel package?
Securing a DTW to TYS flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip in one place. Select from our extensive range of accommodations and then add car rentals, flights and activities to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS)?
In most cases, you can cancel or reschedule your DTW to TYS flight. However, additional fees may apply, especially if you booked over 24 hours ago. Double-check your itinerary for the airline’s guidelines and fees on flight changes, or if you’d like further details, go to our Customer Service portal.

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*Available to One Key members.