$248 Cheap Flights from Detroit (DTW) to Muscle Shoals (MSL)

View $248 flight on Tue, May 20, 2025Opens in a new window

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Find available prices by choosing your travel dates.

Cheap Flights from Detroit to Muscle Shoals (DTW-MSL)

Prices were available within the past 7 days and start at $248 for one-way flights and $362 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Sep 24 - Sat, Sep 27
DTW
Detroit
MSL
Muscle Shoals
$362 Roundtrip, found 3 days ago
$362
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Sep 24 from Detroit to Muscle Shoals, returning Sat, Sep 27, priced at $362 found 3 days ago
American Airlines
Sat, Aug 16 - Wed, Aug 27
DTW
Detroit
MSL
Muscle Shoals
$392 Roundtrip, found 5 days ago
$392
Roundtrip
found 5 days ago
Select American Airlines flight, departing Sat, Aug 16 from Detroit to Muscle Shoals, returning Wed, Aug 27, priced at $392 found 5 days ago
American Airlines
Tue, Jun 17 - Sat, Jun 28
DTW
Detroit
MSL
Muscle Shoals
$398 Roundtrip, found 3 days ago
$398
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Jun 17 from Detroit to Muscle Shoals, returning Sat, Jun 28, priced at $398 found 3 days ago
American Airlines
Wed, May 21 - Tue, Jun 3
DTW
Detroit
MSL
Muscle Shoals
$408 Roundtrip, found 3 days ago
$408
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, May 21 from Detroit to Muscle Shoals, returning Tue, Jun 3, priced at $408 found 3 days ago
American Airlines
Tue, Aug 19 - Mon, Aug 25
DTW
Detroit
MSL
Muscle Shoals
$413 Roundtrip, found 5 days ago
$413
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Aug 19 from Detroit to Muscle Shoals, returning Mon, Aug 25, priced at $413 found 5 days ago
American Airlines
Wed, Sep 24 - Sun, Sep 28
DTW
Detroit
MSL
Muscle Shoals
$421 Roundtrip, found 3 days ago
$421
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Sep 24 from Detroit to Muscle Shoals, returning Sun, Sep 28, priced at $421 found 3 days ago
American Airlines
Tue, Aug 19 - Mon, Aug 25
DTW
Detroit
MSL
Muscle Shoals
$423 Roundtrip, found 5 days ago
$423
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Aug 19 from Detroit to Muscle Shoals, returning Mon, Aug 25, priced at $423 found 5 days ago
American Airlines
Sat, May 10 - Tue, May 27
DTW
Detroit
MSL
Muscle Shoals
$424 Roundtrip, found 3 days ago
$424
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, May 10 from Detroit to Muscle Shoals, returning Tue, May 27, priced at $424 found 3 days ago
American Airlines
Tue, Jul 1 - Sat, Jul 12
DTW
Detroit
MSL
Muscle Shoals
$428 Roundtrip, found 3 days ago
$428
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Jul 1 from Detroit to Muscle Shoals, returning Sat, Jul 12, priced at $428 found 3 days ago
United
Tue, Aug 19 - Mon, Aug 25
DTW
Detroit
MSL
Muscle Shoals
$482 Roundtrip, found 5 days ago
$482
Roundtrip
found 5 days ago
Select United flight, departing Tue, Aug 19 from Detroit to Muscle Shoals, returning Mon, Aug 25, priced at $482 found 5 days ago
Flights from Detroit (DTW) to Muscle Shoals (MSL)
Origin airport
Detroit Metropolitan Wayne County
Destination airport
Northwest Alabama Regional
Roundtrip price
$362
Distance
565 mi

Detroit to Muscle Shoals Flights

The cheapest times to fly from Detroit to Muscle Shoals

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Detroit to Muscle Shoals are during the month of September. You can find some of the cheapest flights from Detroit to Muscle Shoals with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Detroit to Muscle Shoals

Sunday is one of the best days to book for cheap flights from Detroit to Muscle Shoals: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Detroit to Muscle Shoals

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Detroit to Muscle Shoals in 2025. You can also book with separate airlines for your outbound and return journeys, from $248 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Detroit to Muscle Shoals flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Detroit to Muscle Shoals airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Detroit Metropolitan Wayne County Airport (DTW) to Northwest Alabama Regional Airport (MSL) cost?
Discover the latest flight deals from DTW to MSL by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from DTW to MSL?
The cheapest flights from DTW to MSL are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from DTW to MSL?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from DTW to MSL. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Detroit Metropolitan Wayne County Airport (DTW) to Northwest Alabama Regional Airport (MSL)?
There are no daily nonstop flights departing from Detroit Metropolitan Wayne County Airport (DTW) to Northwest Alabama Regional Airport (MSL). But you can choose flights with layovers. Filter your search on Expedia to include one or more stops, and you’ll be cruising above the clouds in no time at all.
What day of the week has the most flights from DTW to MSL?
Friday is usually the busiest day for flights, while Tuesday is often the quietest.* Just remember that flight schedules can change depending on a range of factors, such as the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Detroit Metropolitan Wayne County Airport (DTW) to Northwest Alabama Regional Airport (MSL)?
To touch down at Northwest Alabama Regional Airport (MSL) on time, pick a flight that takes off from Detroit Metropolitan Wayne County Airport (DTW) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
What airports do you fly into for Muscle Shoals from Detroit Metropolitan Wayne County Airport (DTW)?
Browse your flight options from Detroit Metropolitan Wayne County Airport (DTW) to Huntsville Intl. Airport (HSV). This is the only airport in Muscle Shoals you can fly into if you’re taking a direct flight.
Is it cheaper to buy a plane ticket from Detroit Metropolitan Wayne County Airport (DTW) to Northwest Alabama Regional Airport (MSL) last-minute?
Waiting until right before your break to book a flight from DTW to MSL generally means paying more. Although you may find some last-minute offers, they’re not always guaranteed. Be flexible with your travel plans to boost your chances of getting a bargain.
Is it cheaper to book a DTW to MSL flight and hotel package?
Compared with arranging hotels and flights separately, booking a DTW to MSL flight and hotel package with Expedia could result in significant savings. Better still, having everything in one easy place will take the stress out of planning your trip. Simply secure your flights and choose from our wide range of hotels, then customize your trip with extras like activities and car rentals.
Can I cancel or change the date of my flight from Detroit Metropolitan Wayne County Airport (DTW) to Northwest Alabama Regional Airport (MSL)?
If you booked your DTW to MSL flight within the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of fare you have, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for more details.

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*Available to One Key members.