$100 Cheap Flights from Des Moines (DSM) to Knoxville (TYS)

View $100 flight on Fri, Jul 4, 2025Opens in a new window
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Cheap Flights from Des Moines to Knoxville (DSM-TYS)

Prices were available within the past 7 days and start at $100 for one-way flights and $217 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Sun, May 25 - Fri, May 30
DSM
Des Moines
TYS
Knoxville
$217 Roundtrip, found 1 day ago
$217
Roundtrip
found 1 day ago
Select Delta flight, departing Sun, May 25 from Des Moines to Knoxville, returning Fri, May 30, priced at $217 found 1 day ago
Delta
Sun, May 25 - Wed, May 28
DSM
Des Moines
TYS
Knoxville
$221 Roundtrip, found 5 days ago
$221
Roundtrip
found 5 days ago
Select Delta flight, departing Sun, May 25 from Des Moines to Knoxville, returning Wed, May 28, priced at $221 found 5 days ago
American Airlines
Wed, May 28 - Sun, Jun 1
DSM
Des Moines
TYS
Knoxville
$224 Roundtrip, found 2 hours ago
$224
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Wed, May 28 from Des Moines to Knoxville, returning Sun, Jun 1, priced at $224 found 2 hours ago
Delta
Sat, Jul 5 - Wed, Jul 9
DSM
Des Moines
TYS
Knoxville
$233 Roundtrip, found 5 hours ago
$233
Roundtrip
found 5 hours ago
Select Delta flight, departing Sat, Jul 5 from Des Moines to Knoxville, returning Wed, Jul 9, priced at $233 found 5 hours ago
Delta
Sun, May 25 - Wed, May 28
DSM
Des Moines
TYS
Knoxville
$237 Roundtrip, found 5 days ago
$237
Roundtrip
found 5 days ago
Select Delta flight, departing Sun, May 25 from Des Moines to Knoxville, returning Wed, May 28, priced at $237 found 5 days ago
Delta
Fri, May 9 - Thu, May 29
DSM
Des Moines
TYS
Knoxville
$238 Roundtrip, found 1 day ago
$238
Roundtrip
found 1 day ago
Select Delta flight, departing Fri, May 9 from Des Moines to Knoxville, returning Thu, May 29, priced at $238 found 1 day ago
Delta
Tue, Jul 1 - Wed, Jul 9
DSM
Des Moines
TYS
Knoxville
$243 Roundtrip, found 5 days ago
$243
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Jul 1 from Des Moines to Knoxville, returning Wed, Jul 9, priced at $243 found 5 days ago
United
Tue, Oct 14 - Sat, Oct 18
DSM
Des Moines
TYS
Knoxville
$249 Roundtrip, found 9 hours ago
$249
Roundtrip
found 9 hours ago
Select United flight, departing Tue, Oct 14 from Des Moines to Knoxville, returning Sat, Oct 18, priced at $249 found 9 hours ago
Delta
Fri, May 9 - Wed, May 21
DSM
Des Moines
TYS
Knoxville
$254 Roundtrip, found 1 day ago
$254
Roundtrip
found 1 day ago
Select Delta flight, departing Fri, May 9 from Des Moines to Knoxville, returning Wed, May 21, priced at $254 found 1 day ago
American Airlines
Sat, Jul 12 - Sat, Jul 19
DSM
Des Moines
TYS
Knoxville
$254 Roundtrip, found 1 hour ago
$254
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Sat, Jul 12 from Des Moines to Knoxville, returning Sat, Jul 19, priced at $254 found 1 hour ago

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to McGhee Tyson Airport (TYS) cost?
Discover the latest flight deals from DSM to TYS by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from DSM to TYS?
The cheapest flights from DSM to TYS are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from DSM to TYS?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from DSM to TYS. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Des Moines Intl. Airport (DSM) to McGhee Tyson Airport (TYS)?
There are no daily nonstop flights from Des Moines Intl. Airport (DSM) to McGhee Tyson Airport (TYS). But you can book flights with layovers. Filter your search results on Expedia to include one or more stops, and you’ll be soaring above the clouds in no time at all.
What day of the week has the most flights from DSM to TYS?
Friday is typically the busiest day for flights, while Tuesday is often the quietest.* Just remember that flight schedules can change depending on a number of factors, including the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What airline has the least delays from DSM to TYS?
Consider booking with Delta Air Lines if you’d like to fly straight from Des Moines Intl. Airport (DSM) to McGhee Tyson Airport (TYS) without any delays. This airline has the strongest track record for punctuality, with an on-time performance of 100%. Want to be notified if anything changes? You can check your flight status using the Expedia App.
What is the best time to fly from Des Moines Intl. Airport (DSM) to McGhee Tyson Airport (TYS)?
Choose a flight from Des Moines Intl. Airport (DSM) to McGhee Tyson Airport (TYS) that leaves before 3 PM to reduce the likelihood of delays. Departures after this hour are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to McGhee Tyson Airport (TYS) last-minute?
Booking your plane ticket from DSM to TYS shortly before your trip is typically more expensive. But if you’re flexible with your schedule, you could snag a cheap last-minute fare.
Is it cheaper to book a DSM to TYS flight and hotel package?
Compared with arranging flights and hotels separately, booking a DSM to TYS flight and hotel package with Expedia could lead to significant savings. What’s more, managing everything in one place will take the hassle out of planning your trip. Simply secure your flights and choose from our wide range of hotels, then customize your trip with other add-ons like tours, car rentals and activities.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to McGhee Tyson Airport (TYS)?
Generally, it’s possible to cancel or reschedule your DSM to TYS flight. However, if the booking was made more than 24 hours ago, additional fees may apply. Check your airline’s policies in your itinerary to see what changes are possible and whether any costs are involved. You’ll also find further details on our Customer Service portal.
*Available to One Key members.