$143 Cheap Flights from Des Moines (DSM) to Jacksonville (JAX)

View $143 flight on Wed, May 14, 2025Opens in a new window

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Find available prices by choosing your travel dates.

Cheap Flights from Des Moines to Jacksonville (DSM-JAX)

Prices were available within the past 7 days and start at $143 for one-way flights and $285 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Southwest Airlines
Tue, Jun 3 - Wed, Jun 11
DSM
Des Moines
JAX
Jacksonville
$285 Roundtrip, found 3 days ago
$285
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Tue, Jun 3 from Des Moines to Jacksonville, returning Wed, Jun 11, priced at $285 found 3 days ago
Delta
Wed, May 14 - Tue, May 20
DSM
Des Moines
JAX
Jacksonville
$285 Roundtrip, found 2 hours ago
$285
Roundtrip
found 2 hours ago
Select Delta flight, departing Wed, May 14 from Des Moines to Jacksonville, returning Tue, May 20, priced at $285 found 2 hours ago
American Airlines
Sat, May 17 - Tue, May 20
DSM
Des Moines
JAX
Jacksonville
$301 Roundtrip, found 2 hours ago
$301
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Sat, May 17 from Des Moines to Jacksonville, returning Tue, May 20, priced at $301 found 2 hours ago
American Airlines
Sat, May 17 - Tue, May 20
DSM
Des Moines
JAX
Jacksonville
$301 Roundtrip, found 2 hours ago
$301
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Sat, May 17 from Des Moines to Jacksonville, returning Tue, May 20, priced at $301 found 2 hours ago
Southwest Airlines
Wed, Jun 4 - Mon, Jun 9
DSM
Des Moines
JAX
Jacksonville
$302 Roundtrip, found 5 hours ago
$302
Roundtrip
found 5 hours ago
Select Southwest Airlines flight, departing Wed, Jun 4 from Des Moines to Jacksonville, returning Mon, Jun 9, priced at $302 found 5 hours ago
United
Wed, Jun 4 - Mon, Jun 9
DSM
Des Moines
JAX
Jacksonville
$302 Roundtrip, found 5 hours ago
$302
Roundtrip
found 5 hours ago
Select United flight, departing Wed, Jun 4 from Des Moines to Jacksonville, returning Mon, Jun 9, priced at $302 found 5 hours ago
Delta
Wed, Jun 25 - Sat, Jul 5
DSM
Des Moines
JAX
Jacksonville
$306 Roundtrip, found 3 hours ago
$306
Roundtrip
found 3 hours ago
Select Delta flight, departing Wed, Jun 25 from Des Moines to Jacksonville, returning Sat, Jul 5, priced at $306 found 3 hours ago
Delta
Wed, Jun 4 - Mon, Jun 9
DSM
Des Moines
JAX
Jacksonville
$307 Roundtrip, found 5 hours ago
$307
Roundtrip
found 5 hours ago
Select Delta flight, departing Wed, Jun 4 from Des Moines to Jacksonville, returning Mon, Jun 9, priced at $307 found 5 hours ago
American Airlines
Thu, May 22 - Tue, May 27
DSM
Des Moines
JAX
Jacksonville
$307 Roundtrip, found 8 hours ago
$307
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Thu, May 22 from Des Moines to Jacksonville, returning Tue, May 27, priced at $307 found 8 hours ago
Delta
Wed, May 14 - Mon, May 19
DSM
Des Moines
JAX
Jacksonville
$312 Roundtrip, found 16 hours ago
$312
Roundtrip
found 16 hours ago
Select Delta flight, departing Wed, May 14 from Des Moines to Jacksonville, returning Mon, May 19, priced at $312 found 16 hours ago
Flights from Des Moines (DSM) to Jacksonville (JAX)
Origin airport
Des Moines Intl.
Destination airport
Jacksonville Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$284
Distance
1012 mi

Des Moines to Jacksonville Flights

The cheapest times to fly from Des Moines to Jacksonville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Jacksonville are during the month of June. You can find some of the cheapest flights from Des Moines to Jacksonville with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Des Moines to Jacksonville

Sunday is one of the best days to book for cheap flights from Des Moines to Jacksonville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Des Moines to Jacksonville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Jacksonville in 2025. You can also book with separate airlines for your outbound and return journeys, from $143 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Jacksonville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Jacksonville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Jacksonville Intl. Airport (JAX) cost?
Discover the latest flight deals from DSM to JAX by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from DSM to JAX?
The cheapest flights from DSM to JAX are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from DSM to JAX?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from DSM to JAX. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Des Moines Intl. Airport (DSM) to Jacksonville Intl. Airport (JAX)?
There are no daily direct flights available from Des Moines Intl. Airport (DSM) to Jacksonville Intl. Airport (JAX). But you can opt for flights with layovers. Filter your search on Expedia to include one or more stops, and you’ll be soaring above the clouds in no time.
What day of the week has the most flights from DSM to JAX?
Usually you’ll find the largest variety of flight choices on a Friday. Tuesdays are often the quietest.* However, this can vary based on the time of year, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Jacksonville Intl. Airport (JAX)?
To touch down at Jacksonville Intl. Airport (JAX) on time, pick a flight that takes off from Des Moines Intl. Airport (DSM) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Jacksonville Intl. Airport (JAX) last-minute?
Waiting until just before your trip to book a flight from DSM to JAX generally means paying more. While you may find some last-minute deals, there’s no guarantee. Be flexible with your travel plans to boost your chances of landing a bargain.
Is it cheaper to book a DSM to JAX flight and hotel package?
Opting for a DSM to JAX flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our wide range of hotels and then add flights, activities and car rentals to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Jacksonville Intl. Airport (JAX)?
In most instances, you can cancel or modify your DSM to JAX flight. However, there may be additional charges, especially if you made your booking more than 24 hours ago. Double-check your itinerary for the airline’s fees and policies on flight changes, or if you want more information, head to our Customer Service portal.

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*Available to One Key members.