Cheap Flights from Des Moines (DSM) to Mesa (AZA)

Popular airlines from Des Moines International Airport (DSM) to Phoenix - Mesa Gateway Airport (AZA)

Find available prices by choosing your travel dates.
Flights from Des Moines (DSM) to Mesa (AZA)
Origin airport
Des Moines Intl.
Destination airport
Phoenix - Mesa Gateway
Distance
1137 mi

Des Moines to Mesa Flights

The cheapest times to fly from Des Moines to Mesa

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Mesa are during the month of . You can find some of the cheapest flights from Des Moines to Mesa with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Des Moines to Mesa

Sunday is one of the best days to book for cheap flights from Des Moines to Mesa: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Des Moines to Mesa

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Mesa in 2025. You can also book with separate airlines for your outbound and return journeys, from one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Mesa flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Mesa airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Phoenix - Mesa Gateway Airport (AZA) cost?
Discover the latest flight deals from DSM to AZA by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from DSM to AZA?
The cheapest flights from DSM to AZA are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from DSM to AZA?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from DSM to AZA. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Des Moines Intl. Airport (DSM) to Phoenix - Mesa Gateway Airport (AZA)?
On average, you can take your pick of 4 nonstop flights taking off from Des Moines Intl. Airport (DSM) to Phoenix - Mesa Gateway Airport (AZA) weekly. If you can’t find one that suits your schedule, think about taking a flight with a layover. Filter your search results on Expedia to include one or more stops and opt for the next best option.
What are the most popular departure times for flights from Des Moines Intl. Airport (DSM) to Phoenix - Mesa Gateway Airport (AZA)?
Flights between DSM and AZA are busiest at 10 AM. If you want a more relaxed trip and potentially cheaper tickets, choose a departure that’s outside typical rush times.
What day of the week has the most flights from DSM to AZA?
Jet off on a Friday if you’re searching for the best selection of flights from Des Moines Intl. Airport (DSM) to Phoenix - Mesa Gateway Airport (AZA).
What is the earliest flight from Des Moines Intl. Airport (DSM) to Phoenix - Mesa Gateway Airport (AZA)?
The earliest flight leaving Des Moines Intl. Airport (DSM) is at around 10:00AM UTC-6. Board this plane and you’ll land at Phoenix - Mesa Gateway Airport (AZA) at approximately 12:18PM UTC-7. The overall travel time is 3h 18m.
How long does it take to fly from Des Moines Intl. Airport (DSM) to Phoenix - Mesa Gateway Airport (AZA)?
Flights from DSM to AZA have an average travel time of 3 hours and 18 minutes. The total distance between these two airports is 1,150 mi.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Phoenix - Mesa Gateway Airport (AZA)?
To arrive at Phoenix - Mesa Gateway Airport (AZA) without delays, opt for a flight that leaves from Des Moines Intl. Airport (DSM) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
What airports do you fly into for Phoenix from Des Moines Intl. Airport (DSM)?
If you’re departing on a direct flight from Des Moines Intl. Airport (DSM) to Phoenix, you’ll land at either Sky Harbor Intl. Airport (PHX) or Phoenix - Mesa Gateway Airport (AZA).
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Phoenix - Mesa Gateway Airport (AZA) last-minute?
Last-minute fares from DSM to AZA are typically more expensive. To secure the best prices, start looking for flights well ahead of time. That said, if you’re flexible with your travel plans, you may land a cheap fare right before your journey.
Is it cheaper to book a DSM to AZA flight and hotel package?
You’ll generally save money by booking a DSM to AZA flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it’s easy to manage it all in one convenient place. Once you’ve chosen your ideal flights and accommodations, consider adding extras like tours, car rentals and activities.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Phoenix - Mesa Gateway Airport (AZA)?
In most instances, you can modify or cancel your DSM to AZA flight. However, there may be additional charges, especially if your booking was made more than 24 hours ago. Double-check your itinerary for the airline’s rules and fees on flight changes, or if you need more information, head to our Customer Service portal.

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*Available to One Key members.