$73 Cheap Flights from Denver (DEN) to Knoxville (TYS)

View $73 flight on Thu, Aug 14, 2025Opens in a new window

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Find available prices by choosing your travel dates.

Cheap Flights from Denver to Knoxville (DEN-TYS)

Prices were available within the past 7 days and start at $73 for one-way flights and $166 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Sun, May 25 - Thu, May 29
DEN
Denver
TYS
Knoxville
$166 Roundtrip, found 3 hours ago
$166
Roundtrip
found 3 hours ago
Select Frontier Airlines flight, departing Sun, May 25 from Denver to Knoxville, returning Thu, May 29, priced at $166 found 3 hours ago
Frontier Airlines
Thu, Aug 14 - Sun, Aug 17
DEN
Denver
TYS
Knoxville
$173 Roundtrip, found 8 hours ago
$173
Roundtrip
found 8 hours ago
Select Frontier Airlines flight, departing Thu, Aug 14 from Denver to Knoxville, returning Sun, Aug 17, priced at $173 found 8 hours ago
Frontier Airlines
Thu, Aug 7 - Sun, Aug 10
DEN
Denver
TYS
Knoxville
$178 Roundtrip, found 6 hours ago
$178
Roundtrip
found 6 hours ago
Select Frontier Airlines flight, departing Thu, Aug 7 from Denver to Knoxville, returning Sun, Aug 10, priced at $178 found 6 hours ago
Frontier Airlines
Thu, Jul 31 - Sun, Aug 3
DEN
Denver
TYS
Knoxville
$189 Roundtrip, found 15 hours ago
$189
Roundtrip
found 15 hours ago
Select Frontier Airlines flight, departing Thu, Jul 31 from Denver to Knoxville, returning Sun, Aug 3, priced at $189 found 15 hours ago
Frontier Airlines
Sun, Jun 1 - Thu, Jun 5
DEN
Denver
TYS
Knoxville
$197 Roundtrip, found 5 hours ago
$197
Roundtrip
found 5 hours ago
Select Frontier Airlines flight, departing Sun, Jun 1 from Denver to Knoxville, returning Thu, Jun 5, priced at $197 found 5 hours ago
Frontier Airlines
Sun, Jul 6 - Sun, Jul 13
DEN
Denver
TYS
Knoxville
$199 Roundtrip, found 2 days ago
$199
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Sun, Jul 6 from Denver to Knoxville, returning Sun, Jul 13, priced at $199 found 2 days ago
Frontier Airlines
Thu, Jun 19 - Thu, Jun 26
DEN
Denver
TYS
Knoxville
$200 Roundtrip, found 16 hours ago
$200
Roundtrip
found 16 hours ago
Select Frontier Airlines flight, departing Thu, Jun 19 from Denver to Knoxville, returning Thu, Jun 26, priced at $200 found 16 hours ago
United
Tue, May 20 - Tue, Jun 3
DEN
Denver
TYS
Knoxville
$229 Roundtrip, found 8 hours ago
$229
Roundtrip
found 8 hours ago
Select United flight, departing Tue, May 20 from Denver to Knoxville, returning Tue, Jun 3, priced at $229 found 8 hours ago
American Airlines
Sat, Oct 4 - Wed, Oct 8
DEN
Denver
TYS
Knoxville
$249 Roundtrip, found 1 hour ago
$249
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Sat, Oct 4 from Denver to Knoxville, returning Wed, Oct 8, priced at $249 found 1 hour ago
Delta
Sat, Oct 4 - Wed, Oct 8
DEN
Denver
TYS
Knoxville
$249 Roundtrip, found 1 hour ago
$249
Roundtrip
found 1 hour ago
Select Delta flight, departing Sat, Oct 4 from Denver to Knoxville, returning Wed, Oct 8, priced at $249 found 1 hour ago
Flights from Denver (DEN) to Knoxville (TYS)
Origin airport
Denver Intl.
Destination airport
McGhee Tyson
Airlines serving
American Airlines, Delta, Frontier Airlines, United
Roundtrip price
$166
Distance
1159 mi

Denver to Knoxville Flights

The cheapest times to fly from Denver to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Denver to Knoxville are during the month of May. You can find some of the cheapest flights from Denver to Knoxville with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Denver to Knoxville

Sunday is one of the best days to book for cheap flights from Denver to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Denver to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Denver to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $73 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Denver to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Denver to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Denver Intl. Airport (DEN) to McGhee Tyson Airport (TYS) cost?
You can pick up cheap return tickets starting at $172 from Denver Intl. Airport (DEN) to McGhee Tyson Airport (TYS). This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a Frontier Airlines flight leaving DEN on May 6 2025 and touching down at TYS. The price was last updated on April 24 2025 and has not changed since.
What is the cheapest month to fly from DEN to TYS?
The cheapest flights from DEN to TYS are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Denver Intl. Airport (DEN) to McGhee Tyson Airport (TYS)?
You can fly directly from Denver Intl. Airport (DEN) to McGhee Tyson Airport (TYS) on a United Airlines flight.
What is the cheapest airline that flies from DEN to TYS?
Take off from DEN to TYS with Frontier Airlines. This carrier currently has the cheapest one-way fare for this route, starting at $94. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from DEN on June 15 2025. Prices were last updated on April 24 2025 and have not changed since.
How many flights per day from Denver Intl. Airport (DEN) to McGhee Tyson Airport (TYS)?
Every day, an average of 2 direct flights operate from Denver Intl. Airport (DEN) to McGhee Tyson Airport (TYS). Pick the departure time that best fits your schedule.
What are the most popular departure times for flights from Denver Intl. Airport (DEN) to McGhee Tyson Airport (TYS)?
More travelers fly between DEN and TYS at 5 PM than at any other time. Rather go when it’s quieter? Pick a flight outside the busiest times and it’s possible you’ll save on your ticket as well.
What day of the week has the most flights from DEN to TYS?
If you fly on a Sunday, you’ll get the biggest range of choices for flights from Denver Intl. Airport (DEN) to McGhee Tyson Airport (TYS).
What is the earliest flight from Denver Intl. Airport (DEN) to McGhee Tyson Airport (TYS)?
Catch the earliest flight at around 9:59AM UTC-7, departing from Denver Intl. Airport (DEN). You’ll be in the air for around 3h, reaching McGhee Tyson Airport (TYS) at approximately 2:59PM UTC-5.
How long does it take to fly from Denver Intl. Airport (DEN) to McGhee Tyson Airport (TYS)?
The average flight time from DEN to TYS is 2 hours and 57 minutes, covering a total distance of 1,150 mi.
What is the best time to fly from Denver Intl. Airport (DEN) to McGhee Tyson Airport (TYS)?
Book a flight from Denver Intl. Airport (DEN) to McGhee Tyson Airport (TYS) that leaves before 3 PM to reduce the likelihood of delays and cancellations. Later departures are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
What airports do you fly into for Knoxville from Denver Intl. Airport (DEN)?
McGhee Tyson Airport (TYS) is the only airport in Knoxville with direct flights from Denver Intl. Airport (DEN). Compare the available options and find affordable fares on Expedia.
Is it cheaper to buy a plane ticket from Denver Intl. Airport (DEN) to McGhee Tyson Airport (TYS) last-minute?
Holding off until just before your trip to book a flight from DEN to TYS often results in higher prices. While it’s possible to find some last-minute discounts, they’re not always guaranteed. Be flexible with your travel plans to maximize your chances of getting a bargain.
Is it cheaper to book a DEN to TYS flight and hotel package?
You’ll generally save money by securing a DEN to TYS flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it’s easy to manage it all in one convenient place. After selecting your ideal accommodations and flights, consider adding extras such as car rentals, tours and activities.
Can I cancel or change the date of my flight from Denver Intl. Airport (DEN) to McGhee Tyson Airport (TYS)?
Generally, it’s possible to cancel or reschedule your DEN to TYS flight. However, if the booking was made more than 24 hours ago, additional charges may apply. Check your airline’s policies in your itinerary to see what changes are possible and if any costs are involved. You’ll also find more information on our Customer Service portal.

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*Available to One Key members.