$140 Cheap Flights from Cusco (CUZ) to Santiago (SCL)

View $140 flight on Tue, Jun 24, 2025Opens in a new window

Popular airlines from Alejandro Velasco Astete Intl. Airport (CUZ) to Santiago Intl. Airport (SCL)

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Find available prices by choosing your travel dates.

Cheap Flights from Cusco to Santiago (CUZ-SCL)

Prices were available within the past 7 days and start at $140 for one-way flights and $295 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

SKY AIRLINE
Fri, Sep 5 - Wed, Sep 10
CUZ
Cusco
SCL
Santiago
$295 Roundtrip, found 2 hours ago
$295
Roundtrip
found 2 hours ago
Select SKY AIRLINE flight, departing Fri, Sep 5 from Cusco to Santiago, returning Wed, Sep 10, priced at $295 found 2 hours ago
LATAM Airlines Group
Thu, Dec 25 - Sat, Jan 31
CUZ
Cusco
SCL
Santiago
$302 Roundtrip, found 4 hours ago
$302
Roundtrip
found 4 hours ago
Select LATAM Airlines Group flight, departing Thu, Dec 25 from Cusco to Santiago, returning Sat, Jan 31, priced at $302 found 4 hours ago
SKY AIRLINE
Thu, Dec 25 - Sat, Jan 31
CUZ
Cusco
SCL
Santiago
$303 Roundtrip, found 4 hours ago
$303
Roundtrip
found 4 hours ago
Select SKY AIRLINE flight, departing Thu, Dec 25 from Cusco to Santiago, returning Sat, Jan 31, priced at $303 found 4 hours ago
LATAM Airlines Group
Fri, May 9 - Fri, May 16
CUZ
Cusco
SCL
Santiago
$308 Roundtrip, found 5 hours ago
$308
Roundtrip
found 5 hours ago
Select LATAM Airlines Group flight, departing Fri, May 9 from Cusco to Santiago, returning Fri, May 16, priced at $308 found 5 hours ago
SKY AIRLINE
Mon, May 5 - Fri, May 16
CUZ
Cusco
SCL
Santiago
$309 Roundtrip, found 1 day ago
$309
Roundtrip
found 1 day ago
Select SKY AIRLINE flight, departing Mon, May 5 from Cusco to Santiago, returning Fri, May 16, priced at $309 found 1 day ago
SKY AIRLINE
Tue, Jul 22 - Fri, Jul 25
CUZ
Cusco
SCL
Santiago
$310 Roundtrip, found 3 days ago
$310
Roundtrip
found 3 days ago
Select SKY AIRLINE flight, departing Tue, Jul 22 from Cusco to Santiago, returning Fri, Jul 25, priced at $310 found 3 days ago
SKY AIRLINE
Fri, Sep 5 - Wed, Sep 10
CUZ
Cusco
SCL
Santiago
$313 Roundtrip, found 2 hours ago
$313
Roundtrip
found 2 hours ago
Select SKY AIRLINE flight, departing Fri, Sep 5 from Cusco to Santiago, returning Wed, Sep 10, priced at $313 found 2 hours ago
SKY AIRLINE
Fri, Sep 5 - Wed, Sep 10
CUZ
Cusco
SCL
Santiago
$314 Roundtrip, found 2 hours ago
$314
Roundtrip
found 2 hours ago
Select SKY AIRLINE flight, departing Fri, Sep 5 from Cusco to Santiago, returning Wed, Sep 10, priced at $314 found 2 hours ago
LATAM Airlines Group
Wed, May 7 - Fri, May 9
CUZ
Cusco
SCL
Santiago
$317 Roundtrip, found 2 days ago
$317
Roundtrip
found 2 days ago
Select LATAM Airlines Group flight, departing Wed, May 7 from Cusco to Santiago, returning Fri, May 9, priced at $317 found 2 days ago
Jetsmart SPA
Fri, May 9 - Thu, May 15
CUZ
Cusco
SCL
Santiago
$333 Roundtrip, found 5 hours ago
$333
Roundtrip
found 5 hours ago
Select Jetsmart SPA flight, departing Fri, May 9 from Cusco to Santiago, returning Thu, May 15, priced at $333 found 5 hours ago
Flights from Cusco (CUZ) to Santiago (SCL)
Origin airport
Alejandro Velasco Astete Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
Jetsmart SPA, LATAM Airlines Group, SKY AIRLINE
Roundtrip price
$295
Distance
1373 mi

Cusco to Santiago Flights

The cheapest times to fly from Cusco to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Cusco to Santiago are during the month of September. You can find some of the cheapest flights from Cusco to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Cusco to Santiago

Sunday is one of the best days to book for cheap flights from Cusco to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Cusco to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Cusco to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $140 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Cusco to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Cusco to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How long does it take to fly from Alejandro Velasco Astete Intl. Airport (CUZ) to Santiago International Airport?
Book your ticket with LATAM Airlines and you’ll be airborne for about 3 hours and 25 minutes. This leading airline has a direct flight that leaves at 9:10AM from Alejandro Velasco Astete Intl. Airport (CUZ) and comes in to land at Arturo Merino Benitez Airport (SCL) at 1:35PM. Expedia has some amazing flight deals, so take a peek at what’s on offer on this route today.
Is it cheaper to buy a plane ticket from Alejandro Velasco Astete Intl. Airport to Nuevo Pudahuel Airport last minute?
Booking your flight from Alejandro Velasco Astete Intl. Airport to SCL at the last minute could save you a tidy sum if you hit the jackpot and find a bargain. However, fares usually don’t get cheaper as the departure date nears. If you hold off, flights could also be booked solid or the best seats taken (because who wants the middle seat?). If you’d rather err on the side of caution, book well ahead of the date you want to leave. Keep in mind that some of the best deals can be found up to a year in advance. If your favorite airline hasn’t released its fares yet, check back regularly as offers are updated on Expedia all the time.
What airline has the least delays from Alejandro Velasco Astete Intl. Airport (CUZ) to Arturo Merino Benitez Airport (SCL)?
If you’d prefer not to be stuck at the airport for hours — or worse, your vacation plans left in tatters because of a flight delay — travel with LATAM Airlines. Around 85% of its Alejandro Velasco Astete Intl. Airport to SCL services arrive on time. You can look up your flight status before setting out for the airport through the Expedia App. It also delivers real-time notifications about other useful things, such as last-minute gate changes and directions to your hotel. Everything you need to know is right there in your pocket!
What airports do you fly into for Santiago from Cusco?
Arturo Merino Benitez Airport (SCL), Valparaiso (VAP-Rodelillo Airfield) and Vina del Mar (KNA) are your choices when jetting from Cusco to Santiago. Approximately 10 mi west of the center of Santiago, Arturo Merino Benitez Airport (SCL) is the city’s major hub. Think about things such as flight departure and arrival times and the distance to your hotel before choosing an airport. Plaza de Armas and Patio Bellavista are two excellent attractions to put on your must-see list when you arrive at your destination.
What are the most popular departure times for flights from Alejandro Velasco Astete Intl. Airport to Nuevo Pudahuel Airport?
Between 9:00 AM - 10:00 AM is when you’ll find lots of LATAM Airlines flights jetting off from CUZ to Santiago International Airport. Our recommendation? Fly out early. With air traffic yet to build up around airports, your odds of jumping on a delay-free flight are higher.
Can I change the date of my flight from Alejandro Velasco Astete Intl. Airport to Arturo Merino Benitez Airport (SCL)?
Make changes quickly to your Alejandro Velasco Astete Intl. Airport (CUZ) to Santiago International Airport flight by logging in to the Expedia Trips portal. Before making any amendments, review the fare conditions in your itinerary to see what you’re allowed to do and what charges may apply. Some airlines charge a change fee per person, in addition to any difference in fares. However, if you booked in the last 24 hours, you may be able to cancel for free and organize new flights. You can also stop by our Customer Service portal for more information and to chat with our Virtual Agent.

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*Available to One Key members.