$384 Cheap Flights from Columbia (COU) to Key West (EYW)

View $384 flight on Tue, Jun 17, 2025Opens in a new window

Popular airlines from Columbia, MO (COU-Columbia Regional) to Key West Intl. Airport (EYW)

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Find available prices by choosing your travel dates.

Cheap Flights from Columbia to Key West (COU-EYW)

Prices were available within the past 7 days and start at $384 for one-way flights and $416 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, Aug 5 - Tue, Aug 12
COU
Columbia
EYW
Key West
$416 Roundtrip, found 6 days ago
$416
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Aug 5 from Columbia to Key West, returning Tue, Aug 12, priced at $416 found 6 days ago
American Airlines
Sat, Nov 8 - Thu, Nov 13
COU
Columbia
EYW
Key West
$443 Roundtrip, found 1 day ago
$443
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Nov 8 from Columbia to Key West, returning Thu, Nov 13, priced at $443 found 1 day ago
American Airlines
Tue, Aug 5 - Tue, Aug 12
COU
Columbia
EYW
Key West
$449 Roundtrip, found 6 days ago
$449
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Aug 5 from Columbia to Key West, returning Tue, Aug 12, priced at $449 found 6 days ago
American Airlines
Sat, Nov 8 - Thu, Nov 13
COU
Columbia
EYW
Key West
$453 Roundtrip, found 1 day ago
$453
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Nov 8 from Columbia to Key West, returning Thu, Nov 13, priced at $453 found 1 day ago
American Airlines
Sat, Nov 8 - Thu, Nov 13
COU
Columbia
EYW
Key West
$465 Roundtrip, found 1 day ago
$465
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Nov 8 from Columbia to Key West, returning Thu, Nov 13, priced at $465 found 1 day ago
American Airlines
Sat, Nov 8 - Thu, Nov 13
COU
Columbia
EYW
Key West
$475 Roundtrip, found 1 day ago
$475
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Nov 8 from Columbia to Key West, returning Thu, Nov 13, priced at $475 found 1 day ago
American Airlines
Sat, Nov 8 - Thu, Nov 13
COU
Columbia
EYW
Key West
$476 Roundtrip, found 2 days ago
$476
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Nov 8 from Columbia to Key West, returning Thu, Nov 13, priced at $476 found 2 days ago
American Airlines
Sat, Nov 8 - Thu, Nov 13
COU
Columbia
EYW
Key West
$482 Roundtrip, found 1 day ago
$482
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Nov 8 from Columbia to Key West, returning Thu, Nov 13, priced at $482 found 1 day ago
American Airlines
Tue, Jun 3 - Tue, Jun 17
COU
Columbia
EYW
Key West
$496 Roundtrip, found 5 days ago
$496
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Jun 3 from Columbia to Key West, returning Tue, Jun 17, priced at $496 found 5 days ago
American Airlines
Sat, Nov 8 - Thu, Nov 13
COU
Columbia
EYW
Key West
$496 Roundtrip, found 9 hours ago
$496
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Sat, Nov 8 from Columbia to Key West, returning Thu, Nov 13, priced at $496 found 9 hours ago
Flights from Columbia (COU) to Key West (EYW)
Origin airport
Columbia Regional
Destination airport
Key West Intl.
Airlines serving
American Airlines
Roundtrip price
$415
Distance
1159 mi

Columbia to Key West Flights

The cheapest times to fly from Columbia to Key West

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Columbia to Key West are during the month of August. You can find some of the cheapest flights from Columbia to Key West with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Columbia to Key West

Sunday is one of the best days to book for cheap flights from Columbia to Key West: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Columbia to Key West

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Columbia to Key West in 2025. You can also book with separate airlines for your outbound and return journeys, from $384 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Columbia to Key West flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Columbia to Key West airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Columbia Regional Airport (COU) to Key West Intl. Airport (EYW) cost?
Discover the latest flight deals from COU to EYW by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from COU to EYW?
The cheapest flights from COU to EYW are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from COU to EYW?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from COU to EYW. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Columbia Regional Airport (COU) to Key West Intl. Airport (EYW)?
Nonstop flights from Columbia Regional Airport (COU) to Key West Intl. Airport (EYW) aren’t available daily, so you’ll have to take a flight with a layover. Explore your options with our filter tool. Enter your dates and pick either “1 Stop” or “2+ Stops.”
What day of the week has the most flights from COU to EYW?
You’ll usually find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Columbia Regional Airport (COU) to Key West Intl. Airport (EYW)?
To avoid possible delays on the Columbia Regional Airport (COU) to Key West Intl. Airport (EYW) route, aim to travel before 3 PM. Departures after this time have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Columbia Regional Airport (COU) to Key West Intl. Airport (EYW) last-minute?
Last-minute bookings from COU to EYW are typically more expensive. To secure the best rates, start searching for flights well in advance. That said, if you’re flexible with your travel dates, it’s possible to score a cheap fare right before you leave.
Is it cheaper to book a COU to EYW flight and hotel package?
Compared with arranging flights and hotels separately, booking a COU to EYW flight and hotel package with Expedia could result in significant savings. Better yet, having everything in one easy place will take the hassle out of planning your trip. Just pick your flights and choose from our wide range of stays, then customize your trip with extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from Columbia Regional Airport (COU) to Key West Intl. Airport (EYW)?
You can usually cancel or reschedule your COU to EYW flight. However, if it’s been more than 24 hours since booking, additional charges may apply. Check your airline’s policies in your itinerary to see what changes are allowed and whether any costs are involved. You’ll also find more details on our Customer Service portal.

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*Available to One Key members.