$149 Cheap Flights from Charlotte (CLT) to Des Moines (DSM)

View $149 flight on Tue, Jun 3, 2025Opens in a new window

Popular airlines from Charlotte-Douglas Intl. Airport (CLT) to Des Moines International Airport (DSM)

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Find available prices by choosing your travel dates.

Cheap Flights from Charlotte to Des Moines (CLT-DSM)

Prices were available within the past 7 days and start at $149 for one-way flights and $257 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Southwest Airlines
Thu, Jun 5 - Tue, Jun 10
CLT
Charlotte
DSM
Des Moines
$257 Roundtrip, found 1 day ago
$257
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Thu, Jun 5 from Charlotte to Des Moines, returning Tue, Jun 10, priced at $257 found 1 day ago
United
Sat, May 24 - Wed, May 28
CLT
Charlotte
DSM
Des Moines
$262 Roundtrip, found 2 days ago
$262
Roundtrip
found 2 days ago
Select United flight, departing Sat, May 24 from Charlotte to Des Moines, returning Wed, May 28, priced at $262 found 2 days ago
Southwest Airlines
Thu, Jun 5 - Tue, Jun 10
CLT
Charlotte
DSM
Des Moines
$280 Roundtrip, found 1 day ago
$280
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Thu, Jun 5 from Charlotte to Des Moines, returning Tue, Jun 10, priced at $280 found 1 day ago
American Airlines
Sat, May 24 - Wed, May 28
CLT
Charlotte
DSM
Des Moines
$285 Roundtrip, found 2 days ago
$285
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, May 24 from Charlotte to Des Moines, returning Wed, May 28, priced at $285 found 2 days ago
Southwest Airlines
Tue, May 13 - Tue, May 20
CLT
Charlotte
DSM
Des Moines
$297 Roundtrip, found 3 days ago
$297
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Tue, May 13 from Charlotte to Des Moines, returning Tue, May 20, priced at $297 found 3 days ago
Southwest Airlines
Thu, Jun 5 - Tue, Jun 10
CLT
Charlotte
DSM
Des Moines
$300 Roundtrip, found 1 day ago
$300
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Thu, Jun 5 from Charlotte to Des Moines, returning Tue, Jun 10, priced at $300 found 1 day ago
United
Sun, May 25 - Wed, May 28
CLT
Charlotte
DSM
Des Moines
$302 Roundtrip, found 8 hours ago
$302
Roundtrip
found 8 hours ago
Select United flight, departing Sun, May 25 from Charlotte to Des Moines, returning Wed, May 28, priced at $302 found 8 hours ago
Southwest Airlines
Wed, Jun 4 - Tue, Jun 10
CLT
Charlotte
DSM
Des Moines
$307 Roundtrip, found 3 days ago
$307
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Wed, Jun 4 from Charlotte to Des Moines, returning Tue, Jun 10, priced at $307 found 3 days ago
American Airlines
Sat, May 24 - Wed, May 28
CLT
Charlotte
DSM
Des Moines
$308 Roundtrip, found 2 days ago
$308
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, May 24 from Charlotte to Des Moines, returning Wed, May 28, priced at $308 found 2 days ago
Delta
Wed, Jun 18 - Sat, Jul 5
CLT
Charlotte
DSM
Des Moines
$350 Roundtrip, found 11 hours ago
$350
Roundtrip
found 11 hours ago
Select Delta flight, departing Wed, Jun 18 from Charlotte to Des Moines, returning Sat, Jul 5, priced at $350 found 11 hours ago
Flights from Charlotte (CLT) to Des Moines (DSM)
Origin airport
Charlotte-Douglas Intl.
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$256
Distance
813 mi

Charlotte to Des Moines Flights

The cheapest times to fly from Charlotte to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Charlotte to Des Moines are during the month of June. You can find some of the cheapest flights from Charlotte to Des Moines with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Charlotte to Des Moines

Sunday is one of the best days to book for cheap flights from Charlotte to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Charlotte to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Charlotte to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $149 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Charlotte to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Charlotte to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Charlotte-Douglas Intl. Airport (CLT) to Des Moines Intl. Airport (DSM) cost?
Grab cheap return tickets starting from $373 from Charlotte-Douglas Intl. Airport (CLT) to Des Moines Intl. Airport (DSM). This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a American Airlines flight leaving CLT on May 15 2025 and touching down at DSM. The price was last updated on April 23 2025 and has not changed since.
What is the cheapest month to fly from CLT to DSM?
The cheapest flights from CLT to DSM are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Charlotte-Douglas Intl. Airport (CLT) to Des Moines Intl. Airport (DSM)?
If you’re departing from Charlotte-Douglas Intl. Airport (CLT), you can board a direct flight to Des Moines Intl. Airport (DSM) with American Airlines.
What is the cheapest airline that flies from CLT to DSM?
Right now, the cheapest carrier operating one-way flights from CLT to DSM is American Airlines. You can book a seat on this route from $200. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from CLT on July 17 2025. Prices were last updated on April 23 2025 and have not changed since.
How many flights per day from Charlotte-Douglas Intl. Airport (CLT) to Des Moines Intl. Airport (DSM)?
Each day, an average of 2 nonstop flights take off from Charlotte-Douglas Intl. Airport (CLT) to Des Moines Intl. Airport (DSM). Choose the departure date that best suits your travel plans.
What are the most popular departure times for flights from Charlotte-Douglas Intl. Airport (CLT) to Des Moines Intl. Airport (DSM)?
The 12 PM departures from CLT to DSM are typically the busiest. These flights can come with a higher price due to their popularity. If you want to save on your fare, book during off-peak hours.
What day of the week has the most flights from CLT to DSM?
Depart on a Monday if you’re searching for the best selection of flights from Charlotte-Douglas Intl. Airport (CLT) to Des Moines Intl. Airport (DSM).
What is the earliest flight from Charlotte-Douglas Intl. Airport (CLT) to Des Moines Intl. Airport (DSM)?
Hop on the earliest flight at around 12:06PM UTC-5, departing from Charlotte-Douglas Intl. Airport (CLT). You’ll be in the air for about 2h 30m, coming in to land at Des Moines Intl. Airport (DSM) at approximately 1:36PM UTC-6.
How long does it take to fly from Charlotte-Douglas Intl. Airport (CLT) to Des Moines Intl. Airport (DSM)?
It takes approximately 2 hours and 32 minutes to cover the 810 mi from CLT to DSM.
What airline has the least delays from CLT to DSM?
With 80% of journeys typically landing on time, American Airlines has the best on-time performance for nonstop flights from Charlotte-Douglas Intl. Airport (CLT) to Des Moines Intl. Airport (DSM). To monitor your flight status and receive notifications if anything changes, simply head to the Expedia App.
What is the best time to fly from Charlotte-Douglas Intl. Airport (CLT) to Des Moines Intl. Airport (DSM)?
To touch down at Des Moines Intl. Airport (DSM) on schedule, book a flight that leaves from Charlotte-Douglas Intl. Airport (CLT) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
What airports do you fly into for Des Moines from Charlotte-Douglas Intl. Airport (CLT)?
If you’re on a direct flight from Charlotte-Douglas Intl. Airport (CLT) to Des Moines, Des Moines Intl. Airport (DSM) is the only airport you can touch down at.
Is it cheaper to buy a plane ticket from Charlotte-Douglas Intl. Airport (CLT) to Des Moines Intl. Airport (DSM) last-minute?
Holding off until just before your departure to book a flight from CLT to DSM often results in higher prices. While you might find some last-minute offers, they’re not always guaranteed. Be flexible with your travel plans to maximize your chances of snagging a bargain.
Is it cheaper to book a CLT to DSM flight and hotel package?
Opting for a CLT to DSM flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels in one place. Pick from our impressive range of stays and then add car rentals, activities and flights to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Charlotte-Douglas Intl. Airport (CLT) to Des Moines Intl. Airport (DSM)?
If you booked your CLT to DSM flight within the last 24 hours, you may be able to cancel or modify it at no cost. Depending on the airline and the fare type you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal if you’d like more information.

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*Available to One Key members.