$142 Cheap Flights from Charleston (CHS) to Panama City (PTY)

View $142 flight on Mon, Jul 7, 2025Opens in a new window

Popular airlines from Charleston Intl. Airport (CHS) to Tocumen Intl. Airport (PTY)

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Find available prices by choosing your travel dates.

Cheap Flights from Charleston to Panama City (CHS-PTY)

Prices were available within the past 7 days and start at $142 for one-way flights and $349 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Mon, Jun 2 - Mon, Jun 9
CHS
Charleston
PTY
Panama City
$349 Roundtrip, found 2 days ago
$349
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Jun 2 from Charleston to Panama City, returning Mon, Jun 9, priced at $349 found 2 days ago
Delta
Mon, Jun 9 - Thu, Jun 12
CHS
Charleston
PTY
Panama City
$349 Roundtrip, found 4 hours ago
$349
Roundtrip
found 4 hours ago
Select Delta flight, departing Mon, Jun 9 from Charleston to Panama City, returning Thu, Jun 12, priced at $349 found 4 hours ago
United
Wed, Jun 11 - Tue, Jun 17
CHS
Charleston
PTY
Panama City
$349 Roundtrip, found 4 hours ago
$349
Roundtrip
found 4 hours ago
Select United flight, departing Wed, Jun 11 from Charleston to Panama City, returning Tue, Jun 17, priced at $349 found 4 hours ago
American Airlines
Sun, Jul 6 - Thu, Jul 10
CHS
Charleston
PTY
Panama City
$354 Roundtrip, found 5 hours ago
$354
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Sun, Jul 6 from Charleston to Panama City, returning Thu, Jul 10, priced at $354 found 5 hours ago
Delta
Sun, Jun 15 - Tue, Jun 17
CHS
Charleston
PTY
Panama City
$356 Roundtrip, found 4 hours ago
$356
Roundtrip
found 4 hours ago
Select Delta flight, departing Sun, Jun 15 from Charleston to Panama City, returning Tue, Jun 17, priced at $356 found 4 hours ago
United
Wed, Jun 11 - Thu, Jun 12
CHS
Charleston
PTY
Panama City
$356 Roundtrip, found 4 hours ago
$356
Roundtrip
found 4 hours ago
Select United flight, departing Wed, Jun 11 from Charleston to Panama City, returning Thu, Jun 12, priced at $356 found 4 hours ago
United
Thu, Aug 21 - Mon, Aug 25
CHS
Charleston
PTY
Panama City
$357 Roundtrip, found 7 hours ago
$357
Roundtrip
found 7 hours ago
Select United flight, departing Thu, Aug 21 from Charleston to Panama City, returning Mon, Aug 25, priced at $357 found 7 hours ago
American Airlines
Sun, Jul 6 - Thu, Jul 10
CHS
Charleston
PTY
Panama City
$360 Roundtrip, found 5 hours ago
$360
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Sun, Jul 6 from Charleston to Panama City, returning Thu, Jul 10, priced at $360 found 5 hours ago
American Airlines
Sun, Jul 6 - Thu, Jul 10
CHS
Charleston
PTY
Panama City
$361 Roundtrip, found 5 hours ago
$361
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Sun, Jul 6 from Charleston to Panama City, returning Thu, Jul 10, priced at $361 found 5 hours ago
Copa
Fri, Aug 22 - Tue, Aug 26
CHS
Charleston
PTY
Panama City
$1,133 Roundtrip, found 1 hour ago
$1,133
Roundtrip
found 1 hour ago
Select Copa flight, departing Fri, Aug 22 from Charleston to Panama City, returning Tue, Aug 26, priced at $1,133 found 1 hour ago
Flights from Charleston (CHS) to Panama City (PTY)
Origin airport
Charleston Intl.
Destination airport
Tocumen Intl.
Airlines serving
American Airlines, Copa, Delta, United
Roundtrip price
$349
Distance
1646 mi

Charleston to Panama City Flights

The cheapest times to fly from Charleston to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Charleston to Panama City are during the month of June. You can find some of the cheapest flights from Charleston to Panama City with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Charleston to Panama City

Sunday is one of the best days to book for cheap flights from Charleston to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Charleston to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Charleston to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $142 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Charleston to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Charleston to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Charleston Intl. Airport (CHS) to Tocumen Intl. Airport (PTY) cost?
Discover the latest flight deals from CHS to PTY by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from CHS to PTY?
The cheapest flights from CHS to PTY are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from CHS to PTY?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from CHS to PTY. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Charleston Intl. Airport (CHS) to Tocumen Intl. Airport (PTY)?
Direct flights from Charleston Intl. Airport (CHS) to Tocumen Intl. Airport (PTY) aren’t available daily, so you’ll need to take a flight with a layover. Explore your options with Expedia’s filters. Enter your dates and click on either “1 Stop” or “2+ Stops.”
What day of the week has the most flights from CHS to PTY?
You’ll generally find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Charleston Intl. Airport (CHS) to Tocumen Intl. Airport (PTY)?
Select a flight from Charleston Intl. Airport (CHS) to Tocumen Intl. Airport (PTY) that takes off before 3 PM to reduce the likelihood of delays. Later departures are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Charleston Intl. Airport (CHS) to Tocumen Intl. Airport (PTY) last-minute?
Booking your flight from CHS to PTY just before your trip is generally more expensive. However, if there’s some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a CHS to PTY flight and hotel package?
Compared with arranging flights and hotels separately, booking a CHS to PTY flight and hotel package with Expedia could result in significant savings. Better still, having it all in one place takes the hassle out of planning your trip. Simply secure your flights and select from our extensive range of stays, then personalize your trip with other add-ons like car rentals and activities.
Can I cancel or change the date of my flight from Charleston Intl. Airport (CHS) to Tocumen Intl. Airport (PTY)?
In most cases, you can cancel or reschedule your CHS to PTY flight. However, there may be additional fees, especially if your booking was made more than 24 hours ago. Double-check your itinerary for the airline’s fees and rules on flight changes, or if you’d like more details, go to our Customer Service portal.

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*Available to One Key members.