$129 Cheap Flights from Buffalo (BUF) to Myrtle Beach (MYR)

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Find available prices by choosing your travel dates.

Cheap Flights from Buffalo to Myrtle Beach (BUF-MYR)

Prices were available within the past 7 days and start at $129 for one-way flights and $257 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Southwest Airlines
American Airlines
Delta
United
United
Southwest Airlines
United
Delta
American Airlines
Flights from Buffalo (BUF) to Myrtle Beach (MYR)
Origin airport
Buffalo Niagara Intl.
Destination airport
Myrtle Beach Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$256
Distance
639 mi

Buffalo to Myrtle Beach Flights

The cheapest times to fly from Buffalo to Myrtle Beach

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Buffalo to Myrtle Beach are during the month of May. You can find some of the cheapest flights from Buffalo to Myrtle Beach with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Buffalo to Myrtle Beach

Sunday is one of the best days to book for cheap flights from Buffalo to Myrtle Beach: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Buffalo to Myrtle Beach

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Buffalo to Myrtle Beach in 2025. You can also book with separate airlines for your outbound and return journeys, from $129 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Buffalo to Myrtle Beach flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Buffalo to Myrtle Beach airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

Is it cheaper to buy a plane ticket from Buffalo Niagara International Airport to Myrtle Beach Intl. Airport (MYR) last minute?
Booking your journey from Buffalo Niagara Intl. Airport (BUF) to Myrtle Beach Intl. Airport (MYR) at the last minute could save you cash if you strike it lucky and find an amazing deal. However, fares don’t usually get cheaper as the date of departure nears. If you procrastinate, flights could also be booked out or the best seats taken (we hope you like the middle seat!). If you’d rather err on the side of caution, book well ahead of when you want to leave. Remember that some of the most awesome deals can be found up to 12 months in advance. If your preferred carrier hasn’t released tickets yet, check back regularly as offers are constantly updated on Expedia.
What airports do you fly into for Myrtle Beach from Buffalo?
From Buffalo, you can fly into Myrtle Beach via Myrtle Beach Intl. Airport (MYR), Florence Regional Airport (FLO) and Grand Strand Airport (CRE). Research which hub is the best option for you before you make a decision. If you choose Myrtle Beach Intl. Airport (MYR), it’s approximately 3 mi west of the center of the city. Use the cash you save when booking your ticket with Expedia to uncover the city’s top sights, such as Broadway at the Beach and Myrtle Beach Boardwalk.
Can I change the date of my flight from Buffalo Niagara Intl. Airport (BUF) to MYR?
Expedia makes it easy to make amendments to your Buffalo Niagara International Airport to MYR trip yourself. Just log in to the Expedia Trips portal and tap “change flight.” Look around for new flights and lock in the one that works best. You’ll get an estimate of applicable flight change fees. You can also visit our Customer Service portal to chat to our Virtual Agent and get answers to your questions.

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*Available to One Key members.