$149 Cheap Delta flights San Diego (SAN) to Knoxville (TYS)

You’ll discover cheap return Delta Air Lines flights from $268 from SAN to TYS by organizing your results from “Price (lowest to highest)” on Expedia. Or look for options from $149 for a one-way trip.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Browse for return or one-way flights to Knoxville in January or December. You could find lower fares with Delta Air Lines during these off-peak times.

Search for cheap Delta Air Lines flights from San Diego Intl. Airport (SAN) to McGhee Tyson Airport (TYS) one to three months prior to your departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare type and itinerary, the best day of the week to book a domestic flight is usually Sunday and the most expensive is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

To find out if there’s a direct route from SAN to TYS with Delta Air Lines or another airline, select the “Nonstop” filter when searching for tickets.

To find the earliest departure from SAN to TYS with Delta Air Lines, filter your search by “Morning” and “Early Morning.” Choosing an early flight usually means cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

McGhee Tyson Airport (TYS) is the main Knoxville hub for Delta Air Lines flights from San Diego Intl. Airport (SAN).

With an excellent in-flight experience and a rewarding loyalty program, Delta Air Lines is a favorite for many travelers flying from SAN to TYS. Also, if you’re a Delta SkyMiles and One Key™ member booking with Expedia, you could earn OneKeyCash™* on eligible flights on top of your airline miles, which you can put toward future trips.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.

It’s generally possible to cancel or reschedule your flight, although there may be additional fees if your booking was made more than 24 hours ago. Need flexible options? Use our “No cancel fee” and “Changes included” filters to find flights that won’t charge you extra if you need to adjust your plans. To make changes, head to “Trips,” select your flight and click on “Manage Booking” for further information.