$154 Cheap Delta flights Roanoke (ROA) to Chicago (ORD)

Finding cheap one-way Delta Air Lines flights from ROA to ORD from $154 on Expedia couldn’t be easier — just filter by “Price (lowest to highest).” Alternatively, check out our affordable return fares from $229 for your next exciting adventure.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

January is one of the most affordable months to fly to Chicago with Delta Air Lines. You could also find great deals on one-way and round-trip tickets in February.

Begin your search one to three months before your departure to get cheaper fares on Delta Air Lines flights from Roanoke Regional Airport (ROA) to O’Hare Intl. Airport (ORD). You can save 25% by booking your domestic flight 34 to 86 days in advance compared to last-minute reservations made 6 to 12 days out. You could also cut costs by buying your fare on a Sunday, as it’s 6% cheaper on average than a Monday, the most expensive day to book.* Get the timing right, and you can enjoy significant savings on domestic trips.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Click on the “Nonstop” filter when looking for direct Delta Air Lines flights from ROA to ORD. It’s also an easy way to compare other airlines servicing the same nonstop route.

Filter your results by “Morning” and “Early Morning” to find the earliest flights from ROA to ORD. Heading off early means flight cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

O’Hare Intl. Airport (ORD) is the main Chicago gateway for Delta Air Lines flights from Roanoke Regional Airport (ROA).

With an excellent in-flight experience and a rewarding loyalty program, Delta Air Lines is the leading choice for many travelers heading from ROA to ORD. Plus, if you’re a Delta SkyMiles and One Key™ member booking with Expedia, you could earn OneKeyCash™* on eligible flights on top of your airline miles, which can go toward future trips.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.

Changes are often free within 24 hours of making a booking, but your airline may charge you after that. For further details about modifying your reservation, check out your “Trips,” select your flight and click on “Manage Booking.” If you want the flexibility to update your itinerary without extra charges, apply the “Changes included” and “No cancel fee” filters when planning your next escape.