$132 Cheap Delta flights Chicago (ORD) to Des Moines (DSM)

Apply the “Price (lowest to highest)” filter on Expedia to look for cheap Delta Air Lines return flights from $209 from ORD to DSM. Affordable one-way fares from $132 are also on offer.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Look for one-way or return flights to Des Moines in January or December. You could find a cheap fare with Delta Air Lines during these off-season months.

To find cheap Delta Air Lines fares from O’Hare Intl. Airport (ORD) to Des Moines Intl. Airport (DSM), start searching one to three months before your intended departure. Securing domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also influence the cost. Sunday tends to be the most affordable, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking your trip on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Click on the “Nonstop” filter when looking for direct Delta Air Lines flights from ORD to DSM. You’ll also be able to compare other carriers offering the same direct trip.

Search Delta Air Lines’s earliest flights from ORD to DSM by selecting the “Morning” and “Early Morning” filters. Not only will you get to where you’re going sooner, early departures also have a 20% less chance of being canceled.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Jump on a Delta Air Lines flight from O’Hare Intl. Airport (ORD) to Des Moines, and you’ll most likely touch down at Des Moines Intl. Airport (DSM). This is the airline’s primary hub in this city.

With an excellent in-flight experience and a rewarding loyalty program, Delta Air Lines is a favorite for many travelers flying from ORD to DSM. What’s more, if you’re a Delta SkyMiles and One Key™ member booking through Expedia, you could earn OneKeyCash™* on eligible flights on top of your airline miles, which can go toward future trips.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.

Depending on your fare type, a fee may apply if you cancel or reschedule your flight more than 24 hours after confirmation. To find flexible plane tickets, select our “Changes included” and “No cancel fee” boxes when searching for flights. For more information on canceling or modifying your reservation, go to “Trips,” select your flight and click on “Manage Booking.”