$129 Cheap Delta flights Chicago (MDW) to San Francisco (SFO)

Apply the “Price (lowest to highest)” filter on Expedia to search for cheap Delta Air Lines round-trip flights from $237 from MDW to SFO. Affordable one-way fares from $129 are available too.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Search for one-way or round-trip flights to San Francisco in February or April. You could find an affordable fare with Delta Air Lines during these quieter months.

For cheap Delta Air Lines fares from Midway Intl. Airport (MDW) to San Francisco Intl. Airport (SFO), start searching one to three months before your planned departure. Reserving domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also affect the cost. Sunday is typically the most affordable, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking your journey on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

To find out if there’s a direct route from MDW to SFO with Delta Air Lines or any other carriers, select the “Nonstop” filter when searching for flights.

Search Delta Air Lines’s earliest flights from MDW to SFO by selecting the “Morning” and “Early Morning” filters. Not only will you arrive sooner, early departures also experience 20% fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Get on a Delta Air Lines flight from Midway Intl. Airport (MDW) to San Francisco, and you’re most likely to come in to San Francisco Intl. Airport (SFO). This is the airline’s primary hub in this city.

With a rewarding loyalty program and an excellent in-flight experience, Delta Air Lines is the leading choice for many passengers flying from MDW to SFO. Also, if you’re a Delta SkyMiles and One Key™ member booking through Expedia, you could earn OneKeyCash™* on eligible flights on top of your airline miles, which can be spent on future travel purchases.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.

Depending on the ticket type you purchased, a fee is typically charged if you cancel or reschedule your booking more than 24 hours after it has been confirmed. To secure plane tickets with more flexibility, select our “Changes included” and “No cancel fee” boxes when searching for flights. For more information on changing or canceling your reservation, head to “Trips,” select your flight and click on “Manage Booking.”