$177 Cheap American Airlines flights Tucson (TUS) to San Francisco (SFO)

Use the “Price (lowest to highest)” filter on Expedia to search for cheap American Airlines return flights from $229 from TUS to SFO. Affordable one-way fares from $177 are available too.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Search for round-trip or one-way flights to San Francisco in February or April. You could find lower fares with American Airlines during these off-peak travel months.

Begin your search one to three months ahead of your departure date to get cheap fares on American Airlines flights from Tucson Intl. Airport (TUS) to San Francisco Intl. Airport (SFO). You can save 25% by booking your domestic flight 34 to 86 days in advance compared to last-minute reservations made 6 to 12 days out. You could also reduce costs by buying your fare on a Sunday, as it’s 6% cheaper on average than a Monday, the most expensive day to book.* Time it well, and you can enjoy significant savings on domestic journeys.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

To figure out if there’s a direct route from TUS to SFO with American Airlines or another airline, check the “Nonstop” box when browsing for flights.

To find the earliest departure from TUS to SFO with American Airlines, sort your results by “Morning” and “Early Morning.” Booking an early flight generally means you’re less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Catch an American Airlines flight from Tucson Intl. Airport (TUS) to San Francisco, and you’re most likely to land at San Francisco Intl. Airport (SFO). This is the airline’s main hub here.

Depending on your fare type, a fee typically applies if you change or cancel your flight more than 24 hours after it’s been confirmed. To find flexible plane tickets, select our “No cancel fee” or “Changes included” filter when searching for flights. For more details on changing or canceling your reservation, visit “Trips,” select your flight and click on “Manage Booking.”