$179 Cheap American Airlines flights Tampa (TPA) to San Francisco (SFO)

Finding cheap one-way American Airlines flights from TPA to SFO from $179 on Expedia couldn’t be easier — just filter by “Price (lowest to highest).” Or check out our affordable return fares from $301 for your next getaway.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

American Airlines flights to San Francisco tend to be more affordable in the quieter months of February and April. Whether you’re in search of a one-way or a return ticket, you could find a better deal then.

For cheap American Airlines fares from Tampa Intl. Airport (TPA) to San Francisco Intl. Airport (SFO), start searching one to three months before your intended departure. Securing domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also impact what you pay. Sunday is usually the most affordable, while Monday is often the most expensive for domestic flights. You can save 6% on average by choosing to book on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Use our “Nonstop” filter when browsing for direct American Airlines flights from TPA to SFO. It’s also a good way to compare other airlines offering the same nonstop route.

Sort your results by “Morning” and “Early Morning” to browse the earliest flights from TPA to SFO. Jetting off early means you’re less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

San Francisco Intl. Airport (SFO) is the primary San Francisco gateway for American Airlines flights from Tampa Intl. Airport (TPA).

In most cases, you can reschedule or cancel your flight, although there may be a charge if you booked more than 24 hours ago. Prefer to keep your options open? Use our “Changes included” and “No cancel fee” filters to find flights that won’t charge extra if you have to adjust your plans. To update your booking, head to “Trips,” select your flight and click on “Manage Booking” for more details.