$100 Cheap American Airlines flights Tampa (TPA) to Knoxville (TYS)

You can find cheap round-trip American Airlines flights from $199 from TPA to TYS by filtering your results from “Price (lowest to highest)” on Expedia. Or look for deals from $100 for a one-way trip.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

American Airlines flights to Knoxville are typically more affordable in the low-season months of January and December. Whether you’re after a one-way or round-trip ticket, you could find a better deal then.

Start searching one to three months ahead of your departure date to get cheaper fares on American Airlines flights from Tampa Intl. Airport (TPA) to McGhee Tyson Airport (TYS). You can save 25% by booking your domestic flight 34 to 86 days in advance versus last-minute reservations made 6 to 12 days out. You could also reduce costs by buying your fare on a Sunday, as it’s 6% cheaper on average than a Monday, the most expensive day to book.* Get your timing right, and you can enjoy significant savings on domestic flights.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Enter your dates, click search and use the “Nonstop” filter on Expedia to browse any direct flights from TPA to TYS with American Airlines or another airline.

Sort your results by “Early Morning” and “Morning” to see the earliest departures from TPA to TYS. Setting off early means you’re 20% less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

American Airlines flights from Tampa Intl. Airport (TPA) to Knoxville land at McGhee Tyson Airport (TYS). This is the main entry point to this destination.

Typically, you can modify or cancel your flight, although additional fees may apply if your booking was made more than 24 hours ago. Prefer to keep your options open? Make use of our “Changes included” and “No cancel fee” filters to find flights that won’t charge you extra if you have to revise your plans. To make changes, go to “Trips,” select your flight and click on “Manage Booking” for more information.