$115 Cheap American Airlines flights San Diego (SAN) to Knoxville (TYS)

Use the “Price (lowest to highest)” filter on Expedia to find cheap American Airlines return flights from $229 from SAN to TYS. Affordable one-way options from $115 are also available.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Search for one-way or round-trip flights to Knoxville in January or December. You could find cheaper fares with American Airlines during these quieter months.

Search for cheap American Airlines flights from San Diego Intl. Airport (SAN) to McGhee Tyson Airport (TYS) one to three months prior to your departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. Regardless of fare class and journey, the best day of the week to book a domestic flight is usually Sunday and the most expensive day is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book their travel on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

To find out if there’s a direct route from SAN to TYS with American Airlines or other carriers, check the “Nonstop” filter when browsing for flights.

Browse American Airlines’s earliest flights from SAN to TYS by using our “Morning” and “Early Morning” filters. Not only will you arrive sooner, early departures also have a 20% less chance of being canceled.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Take an American Airlines flight from San Diego Intl. Airport (SAN) to Knoxville, and you’ll most likely touch down at McGhee Tyson Airport (TYS). This is the airline’s main hub in this city.

Depending on the type of ticket you purchased, a fee will generally apply if you modify or cancel your booking more than 24 hours after it’s been confirmed. To secure flexible fares, select our “Changes included” or “No cancel fee” filter while searching for flights. To learn more about modifying or canceling your reservation, visit “Trips,” select your flight and click on “Manage Booking.”