$105 Cheap American Airlines flights Roanoke (ROA) to Key West (EYW)

Use the “Price (lowest to highest)” filter on Expedia to find cheap American Airlines round-trip flights from $225 from ROA to EYW. Affordable one-way fares from $105 are also on offer.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

American Airlines flights to Key West are often cheaper in the quieter months of September and August. Whether you need a round-trip or one-way ticket, you could land a better deal then.

To find cheap American Airlines fares from Roanoke Regional Airport (ROA) to Key West Intl. Airport (EYW), start searching one to three months before your intended departure. Securing domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also impact how much you pay. Sunday is generally the cheapest, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking your journey on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Use the “Nonstop” filter when looking for direct American Airlines flights from ROA to EYW. It’s also a great way to compare other airlines servicing the same direct route.

To find the earliest departure from ROA to EYW with American Airlines, sort your results by “Morning” and “Early Morning.” Choosing an early flight usually means you’re less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Key West Intl. Airport (EYW) is the main Key West hub for American Airlines flights from Roanoke Regional Airport (ROA).

It’s generally possible to reschedule or cancel your flight, although additional fees may apply if your booking was made more than 24 hours ago. Want to keep your options open? Make use of our “No cancel fee” or “Changes included” filter to find flights that won’t charge you extra if you have to alter your plans. To modify your itinerary, visit “Trips,” select your flight and click on “Manage Booking” for more information.