$100 Cheap American Airlines flights Raleigh (RDU) to Key West (EYW)

Scoring cheap one-way American Airlines flights from RDU to EYW from $100 on Expedia is a cinch — just filter by “Price (lowest to highest).” Or check out our budget-friendly round-trip fares from $208 for your next exciting vacation.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

American Airlines flights to Key West are generally more affordable in the low-season months of September and August. Whether you’re searching for a return or one-way ticket, you could find a better deal then.

Start searching one to three months ahead of your travel date to get cheap fares on American Airlines flights from Raleigh - Durham Intl. Airport (RDU) to Key West Intl. Airport (EYW). You can save 25% by booking your domestic flight 34 to 86 days in advance versus last-minute reservations made 6 to 12 days out. You could also cut costs by buying your fare on a Sunday, as it’s 6% cheaper on average than a Monday, the most expensive day to book.* Get your timing right, and you can enjoy significant savings on domestic trips.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Click on the “Nonstop” filter when browsing for direct American Airlines flights from RDU to EYW. It’s also a great way to compare other airlines servicing the same direct trip.

To find the earliest departures from RDU to EYW with American Airlines, filter your results by “Early Morning” and “Morning.” Choosing an early flight usually means you’ll experience fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Key West Intl. Airport (EYW) is the main Key West hub for American Airlines flights from Raleigh - Durham Intl. Airport (RDU).

Changes are usually free within 24 hours of making your booking, but your airline may add a charge after that. For more details about altering your reservation, check out your “Trips,” select your flight and click on “Manage Booking.” If you want the freedom to make changes without additional costs, check the “Changes included” or “No cancel fee” filter when organizing your next adventure.