$100 Cheap American Airlines flights Raleigh (RDU) to Buffalo (BUF)

Finding cheap one-way American Airlines flights from RDU to BUF from $100 on Expedia is simple — just filter by “Price (lowest to highest).” Alternatively, check out our budget-friendly round-trip fares from $199 for your next break.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Browse for return or one-way flights to Buffalo in January or February. You could find an affordable fare with American Airlines during these quieter months.

Look for affordable American Airlines flights from Raleigh - Durham Intl. Airport (RDU) to Buffalo Niagara Intl. Airport (BUF) one to three months prior to your day of departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. Regardless of fare type and journey, the best day to book a domestic flight is usually Sunday and the most expensive tends to be Monday. Passengers who book on a Sunday can save 6% on average compared to those who book their travel on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Select our “Nonstop” filter when browsing for direct American Airlines flights from RDU to BUF. You can also compare other carriers servicing the same nonstop journey.

To find the earliest departures from RDU to BUF with American Airlines, filter your search by “Morning” and “Early Morning.” Booking an early flight generally means cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Jump on an American Airlines flight from Raleigh - Durham Intl. Airport (RDU) to Buffalo, and you’ll likely come in to Buffalo Niagara Intl. Airport (BUF). This is the airline’s primary hub in this city.

Depending on the type of ticket you purchased, a fee may apply if you cancel or change your flight more than 24 hours after it’s been confirmed. To secure plane tickets with more flexibility, select our “Changes included” and “No cancel fee” boxes when you look for flights. For more information on canceling or changing your reservation, visit “Trips,” select your flight and tick “Manage Booking.”