$113 Cheap American Airlines flights Philadelphia (PHL) to Des Moines (DSM)

You can find affordable return American Airlines flights from $220 from PHL to DSM by organizing your results from “Price (lowest to highest)” on Expedia. Or search for options from $113 for a one-way journey.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

American Airlines flights to Des Moines tend to be more affordable in the off-peak months of January and December. Whether you’re after a one-way or round-trip ticket, you could find a better deal then.

For cheap American Airlines fares from Philadelphia Intl. Airport (PHL) to Des Moines Intl. Airport (DSM), start searching one to three months before your intended departure. Securing domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also affect the cost. Sunday is typically the most affordable, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking your journey on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Use our “Nonstop” filter when looking for direct American Airlines flights from PHL to DSM. You’ll also be able to compare other carriers servicing the same nonstop trip.

Sort your results by “Morning” and “Early Morning” to see the earliest departures from PHL to DSM. Heading off early means flight cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Des Moines Intl. Airport (DSM) is the main Des Moines hub for American Airlines flights from Philadelphia Intl. Airport (PHL).

Depending on your fare type, a fee may apply if you change or cancel your flight more than 24 hours after it’s confirmed. To secure tickets with more flexibility, select our “Changes included” and “No cancel fee” boxes while looking for flights. For more information on canceling or modifying your reservation, head to “Trips,” select your flight and click on “Manage Booking.”