$149 Cheap American Airlines flights Chicago (ORD) to Manchester (MHT)

Landing cheap one-way American Airlines flights from ORD to MHT from $149 on Expedia is easy — just filter by “Price (lowest to highest).” Or check out our affordable return fares from $297 for your next exciting vacation.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Browse for one-way or return flights to Manchester in February or December. You could find cheaper fares with American Airlines during these quieter months.

Begin your search one to three months ahead of your travel date to find cheap fares on American Airlines flights from O’Hare Intl. Airport (ORD) to Manchester-Boston Regional Airport (MHT). You can save 25% by booking your domestic flight 34 to 86 days in advance versus last-minute reservations made 6 to 12 days out. You could also reduce costs by buying your fare on a Sunday, as it’s 6% cheaper on average than a Monday, the most expensive day to book.* Nail your timing, and you can enjoy significant savings on domestic trips.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Click on our “Nonstop” filter when looking for direct American Airlines flights from ORD to MHT. You’ll also be able to compare other carriers servicing the same direct trip.

Browse American Airlines’s earliest flights from ORD to MHT by checking the “Morning” and “Early Morning” filters. Not only will you arrive at your destination sooner, early departures are also 20% less likely to be canceled.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Manchester-Boston Regional Airport (MHT) is the main Manchester hub for American Airlines flights from O’Hare Intl. Airport (ORD).

Changes are often free within 24 hours of making a booking, but your airline may charge a fee after that time. For more information about altering your reservation, go to your “Trips,” select your flight and click on “Manage Booking.” If you want the flexibility to update your itinerary without additional charges, tick the “Changes included” or “No cancel fee” filter when planning your next adventure.