$144 Cheap American Airlines flights Panama City (ECP) to Key West (EYW)

Make use of the “Price (lowest to highest)” filter on Expedia to look for cheap American Airlines return flights from $347 from ECP to EYW. Affordable one-way tickets from $144 are available as well.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

American Airlines flights to Key West tend to be cheaper in the quieter months of September and August. Whether you’re in search of a return or one-way ticket, you could land a better deal then.

Search for affordable American Airlines flights from Northwest Florida Beaches Intl. Airport (ECP) to Key West Intl. Airport (EYW) one to three months before your day of departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare class and itinerary, the ideal day to book a domestic flight is generally Sunday and the most expensive day is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Enter your dates, click search and check “Nonstop” on Expedia to find any direct flights from ECP to EYW with American Airlines or other airlines.

To find the earliest departure from ECP to EYW with American Airlines, filter your search by “Early Morning” and “Morning.” Booking an early flight generally means you’ll experience fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Catch an American Airlines flight from Northwest Florida Beaches Intl. Airport (ECP) to Key West, and you’ll most likely land at Key West Intl. Airport (EYW). This is the airline’s main hub here.

You can usually cancel or reschedule your flight, although there may be additional charges if you made your booking over 24 hours ago. Need flexible options? Use Expedia’s “Changes included” or “No cancel fee” filter to find flights that won’t penalize you if you have to alter your plans. To update your itinerary, head to “Trips,” select your flight and click on “Manage Booking” for more details.