$154 Cheap American Airlines flights Manchester (MHT) to Key West (EYW)

Grab cheap round-trip American Airlines flights from $307 from MHT to EYW by sorting your results from “Price (lowest to highest)” on Expedia. Or look for bargains from $154 for a one-way trip.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

September is one of the least expensive months to travel to Key West with American Airlines. You could also find great prices on one-way and return fares in August.

Look for cheap American Airlines flights from Manchester-Boston Regional Airport (MHT) to Key West Intl. Airport (EYW) one to three months before your departure day. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare type and itinerary, the best day to book a domestic flight is usually Sunday and the most expensive day is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

To see if there’s a direct route from MHT to EYW with American Airlines or any other carriers, select the “Nonstop” filter when looking for tickets.

To find the earliest departures from MHT to EYW with American Airlines, filter your search by “Early Morning” and “Morning.” Booking an early flight usually means cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Jump on an American Airlines flight from Manchester-Boston Regional Airport (MHT) to Key West, and you’re most likely to come in to Key West Intl. Airport (EYW). This is the airline’s primary hub here.

Changes are often free within 24 hours of making a booking, but your airline may charge a fee after that time. For more information about altering your reservation, head to your “Trips,” select your flight and click on “Manage Booking.” If you want the freedom to adjust your plans without additional charges, tick the “Changes included” or “No cancel fee” filter when planning your next trip.