$143 Cheap American Airlines flights Boston (BOS) to Des Moines (DSM)

Apply the “Price (lowest to highest)” filter on Expedia to look for cheap American Airlines round-trip flights from $285 from BOS to DSM. Affordable one-way tickets from $143 are available as well.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

American Airlines flights to Des Moines are generally more affordable in the quieter months of January and December. Whether you’re after a one-way or round-trip ticket, you could land a better deal then.

Search for affordable American Airlines flights from Logan Intl. Airport (BOS) to Des Moines Intl. Airport (DSM) one to three months before your day of departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare type and itinerary, the best day of the week to book a domestic flight is generally Sunday and the most expensive day is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book their travel on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

To see if there’s a direct journey from BOS to DSM with American Airlines or another carrier, use our “Nonstop” filter when searching for tickets.

Browse American Airlines’s earliest flights from BOS to DSM by using the “Morning” and “Early Morning” filters. Not only will you arrive sooner, early departures also have a 20% less chance of being canceled.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

American Airlines flights from Logan Intl. Airport (BOS) to Des Moines arrive at Des Moines Intl. Airport (DSM). This is the main gateway here.

Changes are generally free within 24 hours of booking, but your airline may add a charge after that. For further details about altering your flights, go to your “Trips,” select your flight and click on “Manage Booking.” If you want the flexibility to change your plans without additional costs, check the “Changes included” or “No cancel fee” filter when organizing your next getaway.