$109 Cheap American Airlines flights New York (LGA) to San Francisco (SFO)

Scoring cheap one-way American Airlines flights from LGA to SFO from $109 on Expedia is easy — just filter by “Price (lowest to highest).” Alternatively, check out our budget-friendly return fares from $213 for your next adventure.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

February is one of the least expensive months to jet off to San Francisco with American Airlines. You could also find excellent prices on one-way and return tickets in April.

Begin your search one to three months ahead of your travel date to get cheaper fares on American Airlines flights from LaGuardia Airport (LGA) to San Francisco Intl. Airport (SFO). You can save 25% by booking your domestic flight 34 to 86 days in advance versus last-minute reservations made 6 to 12 days out. You could also cut costs by buying your fare on a Sunday, as it’s 6% cheaper on average than a Monday, the most expensive day to book.* Time it well, and you can enjoy significant savings on domestic trips.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Use the “Nonstop” filter when looking for direct American Airlines flights from LGA to SFO. It’s also a great way to compare other carriers servicing the same direct route.

To find the earliest departures from LGA to SFO with American Airlines, filter your results by “Morning” and “Early Morning.” Choosing an early flight usually means you’ll experience fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

San Francisco Intl. Airport (SFO) is the main San Francisco hub for American Airlines flights from LaGuardia Airport (LGA).

Changes are often free within 24 hours of making a booking, but your airline may charge you after that time. For more details about altering your reservation, head to your “Trips,” select your flight and click on “Manage Booking.” If you’d like the freedom to change your plans without being charged, apply the “Changes included” and “No cancel fee” filters when planning your next trip.