$121 Cheap American Airlines flights New York (JFK) to St. Louis (STL)

Apply the “Price (lowest to highest)” filter on Expedia to look for cheap American Airlines round-trip flights from $241 from JFK to STL. Affordable one-way options from $121 are also available.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

January is one of the most affordable months to jet off to St. Louis with American Airlines. You could also find excellent prices on return and one-way tickets in February.

Search for affordable American Airlines flights from John F. Kennedy Intl. Airport (JFK) to Lambert-St. Louis Intl. Airport (STL) one to three months ahead of your departure day. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare type and itinerary, the best day of the week to book a domestic flight is generally Sunday and the most expensive is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book their travel on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

To figure out if there’s a direct route from JFK to STL with American Airlines or another carrier, use our “Nonstop” filter when looking for tickets.

To find the earliest departures from JFK to STL with American Airlines, filter your results by “Morning” and “Early Morning.” Booking an early flight usually means cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Lambert-St. Louis Intl. Airport (STL) is the primary St. Louis hub for American Airlines flights from John F. Kennedy Intl. Airport (JFK).

It’s usually possible to cancel or change your flight, although there may be a charge if your booking was made over 24 hours ago. Prefer to keep your options open? Use Expedia’s “No cancel fee” or “Changes included” filter to find flights that won’t charge extra if you have to revise your plans. To modify your itinerary, head to “Trips,” select your flight and click on “Manage Booking” for more details.