$179 Cheap American Airlines flights Detroit (DTW) to Knoxville (TYS)

Grab affordable return American Airlines flights from $291 from DTW to TYS by organizing your results from “Price (lowest to highest)” on Expedia. Or look for options from $179 for a one-way trip.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

January is one of the cheapest months to fly to Knoxville with American Airlines. You could also find fantastic deals on one-way and round-trip fares in December.

Search for cheap American Airlines flights from Detroit Metropolitan Wayne County Airport (DTW) to McGhee Tyson Airport (TYS) one to three months before your departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare type and itinerary, the best day of the week to book a domestic flight is generally Sunday and the most expensive tends to be Monday. Passengers who book on a Sunday can save 6% on average compared to those who book on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Select our “Nonstop” filter when searching for direct American Airlines flights from DTW to TYS. It’s also a good way to compare other carriers offering the same nonstop trip.

To find the earliest departure from DTW to TYS with American Airlines, filter your results by “Early Morning” and “Morning.” Booking an early flight generally means cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Jump on an American Airlines flight from Detroit Metropolitan Wayne County Airport (DTW) to Knoxville, and you’re most likely to land at McGhee Tyson Airport (TYS). This is the airline’s main hub here.

Changes are typically free within 24 hours of making a booking, but your airline may charge a fee after that. For further details about modifying your reservation, head to your “Trips,” select your flight and click on “Manage Booking.” If you’d like the freedom to make changes without being charged, apply the “Changes included” and “No cancel fee” filters when planning your next break.