$150 Cheap American Airlines flights Des Moines (DSM) to Seattle (SEA)

You’ll discover cheap return American Airlines flights from $288 from DSM to SEA by filtering your results from “Price (lowest to highest)” on Expedia. Or search for options from $150 for a one-way journey.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Look for round-trip or one-way flights to Seattle in January or February. You could find an affordable fare with American Airlines during these quieter months.

Begin your search one to three months before your departure to score cheap fares on American Airlines flights from Des Moines Intl. Airport (DSM) to Seattle - Tacoma Intl. Airport (SEA). You can save 25% by booking your domestic flight 34 to 86 days in advance compared to last-minute reservations made 6 to 12 days out. You could also reduce costs by buying your fare on a Sunday, as it’s 6% cheaper on average than a Monday, the most expensive day to book.* Time it well, and you can enjoy significant savings on domestic flights.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

To see if there’s a direct route from DSM to SEA with American Airlines or other airlines, use our “Nonstop” filter when browsing for flights.

To find the earliest departures from DSM to SEA with American Airlines, filter your results by “Early Morning” and “Morning.” Booking an early flight generally means cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Seattle - Tacoma Intl. Airport (SEA) is the main Seattle hub for American Airlines flights from Des Moines Intl. Airport (DSM).

Changes are typically free within 24 hours of booking, but your airline may add a charge after that time. For further details about modifying your reservation, go to your “Trips,” select your flight and click on “Manage Booking.” If you want the freedom to make changes without additional charges, apply the “Changes included” and “No cancel fee” filters when organizing your next getaway.