$121 Cheap American Airlines flights Des Moines (DSM) to Chicago (ORD)

Grab affordable return American Airlines flights from $184 from DSM to ORD by organizing your results from “Price (lowest to highest)” on Expedia. Or look for bargains from $121 for a one-way trip.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Look for one-way or return flights to Chicago in January or February. You could find lower fares with American Airlines during these off-peak times.

To find cheap American Airlines fares from Des Moines Intl. Airport (DSM) to O’Hare Intl. Airport (ORD), start searching one to three months before your intended departure. Securing domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also affect the cost. Sunday tends to be the most affordable, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking your journey on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Book a seat on one of American Airlines’s 21 direct weekly flights from Des Moines Intl. Airport (DSM) to O’Hare Intl. Airport (ORD). To see your options, enter your origin, dates and destination and hit search. Then use the “Nonstop” and “Airline” filters.

Leave Des Moines Intl. Airport (DSM) for O’Hare Intl. Airport (ORD) on a direct American Airlines flight, and you’ll be in the sky for approximately 1h 32m.

If flexibility is what you’re after, Tuesday offers the most choice for American Airlines flights from Des Moines Intl. Airport (DSM) to O’Hare Intl. Airport (ORD). You can pick from 3 different departures.

The earliest flight from DSM to ORD with American Airlines leaves at 5:30AM UTC-6. You’ll land at 7:02AM UTC-6. The final American Airlines flight of the day takes off at 6:00PM UTC-6 and arrives at 7:35PM UTC-6. With approximately 20% fewer cancellations for early and mid-morning flights, jetting out early is often the smartest choice.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

O’Hare Intl. Airport (ORD) is the primary Chicago gateway for American Airlines flights from Des Moines Intl. Airport (DSM).

For the Des Moines Intl. Airport (DSM) to O’Hare Intl. Airport (ORD) route, American Airlines typically flies Embraer 170 and Bombardier CRJ planes. Keep in mind that last-minute changes can occur for operational purposes, so your flight could be on another aircraft.

You can usually cancel or reschedule your flight, although there may be a charge if you booked more than 24 hours ago. Prefer to keep your options open? Use our “No cancel fee” or “Changes included” filter to find flights that won’t penalize you if you need to alter your plans. To make modifications, go to “Trips,” select your flight and click on “Manage Booking” for more information.