$208 Cheap American Airlines flights Denver (DEN) to Knoxville (TYS)

Make use of the “Price (lowest to highest)” filter on Expedia to look for cheap American Airlines round-trip flights from $249 from DEN to TYS. Affordable one-way tickets from $208 are available too.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

American Airlines flights to Knoxville are generally cheaper in the quieter months of January and December. Whether you’re after a return or one-way ticket, you could land a better deal then.

Begin your search one to three months ahead of your travel date to get cheaper fares on American Airlines flights from Denver Intl. Airport (DEN) to McGhee Tyson Airport (TYS). You can save 25% by booking your domestic flight 34 to 86 days in advance versus last-minute reservations made 6 to 12 days out. You could also reduce costs by buying your fare on a Sunday, as it’s 6% cheaper on average than a Monday, the most expensive day to book.* Time it well, and you can enjoy significant savings on domestic flights.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Enter your dates, click search and check the “Nonstop” filter on Expedia to browse any direct flights from DEN to TYS with American Airlines or other airlines.

To find the earliest departures from DEN to TYS with American Airlines, sort your results by “Early Morning” and “Morning.” Booking an early flight generally means you’ll experience fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

American Airlines flights from Denver Intl. Airport (DEN) to Knoxville come in to McGhee Tyson Airport (TYS). This is the main gateway to this destination.

Typically, you can cancel or reschedule your flight, although additional charges may apply if your booking was made more than 24 hours ago. Need to keep your options open? Use Expedia’s “Changes included” or “No cancel fee” filter to find flights that won’t charge you extra if you have to alter your plans. To make modifications, head to “Trips,” select your flight and click on “Manage Booking” for more information.