$227 Cheap Flights from San Antonio (SAT) to Panama City (PTY)

View $227 flight on Wed, Aug 20, 2025Opens in a new window

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Find available prices by choosing your travel dates.

Cheap Flights from San Antonio to Panama City (SAT-PTY)

Prices were available within the past 7 days and start at $227 for one-way flights and $479 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Oct 22 - Wed, Oct 29
SAT
San Antonio
PTY
Panama City
$479 Roundtrip, found 9 hours ago
$479
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Wed, Oct 22 from San Antonio to Panama City, returning Wed, Oct 29, priced at $479 found 9 hours ago
Delta
Mon, Aug 18 - Thu, Aug 21
SAT
San Antonio
PTY
Panama City
$479 Roundtrip, found 1 hour ago
$479
Roundtrip
found 1 hour ago
Select Delta flight, departing Mon, Aug 18 from San Antonio to Panama City, returning Thu, Aug 21, priced at $479 found 1 hour ago
United
Thu, Aug 21 - Tue, Aug 26
SAT
San Antonio
PTY
Panama City
$479 Roundtrip, found 1 hour ago
$479
Roundtrip
found 1 hour ago
Select United flight, departing Thu, Aug 21 from San Antonio to Panama City, returning Tue, Aug 26, priced at $479 found 1 hour ago
United
Wed, Jun 18 - Thu, Jul 31
SAT
San Antonio
PTY
Panama City
$486 Roundtrip, found 2 hours ago
$486
Roundtrip
found 2 hours ago
Select United flight, departing Wed, Jun 18 from San Antonio to Panama City, returning Thu, Jul 31, priced at $486 found 2 hours ago
Delta
Wed, Oct 22 - Wed, Oct 29
SAT
San Antonio
PTY
Panama City
$489 Roundtrip, found 9 hours ago
$489
Roundtrip
found 9 hours ago
Select Delta flight, departing Wed, Oct 22 from San Antonio to Panama City, returning Wed, Oct 29, priced at $489 found 9 hours ago
American Airlines
Wed, Oct 22 - Wed, Oct 29
SAT
San Antonio
PTY
Panama City
$491 Roundtrip, found 9 hours ago
$491
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Wed, Oct 22 from San Antonio to Panama City, returning Wed, Oct 29, priced at $491 found 9 hours ago
United
Tue, Jun 24 - Thu, Jul 3
SAT
San Antonio
PTY
Panama City
$492 Roundtrip, found 13 hours ago
$492
Roundtrip
found 13 hours ago
Select United flight, departing Tue, Jun 24 from San Antonio to Panama City, returning Thu, Jul 3, priced at $492 found 13 hours ago
American Airlines
Wed, Jul 16 - Wed, Jul 23
SAT
San Antonio
PTY
Panama City
$494 Roundtrip, found 1 day ago
$494
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jul 16 from San Antonio to Panama City, returning Wed, Jul 23, priced at $494 found 1 day ago
American Airlines
Tue, Jul 8 - Tue, Jul 22
SAT
San Antonio
PTY
Panama City
$495 Roundtrip, found 23 hours ago
$495
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Tue, Jul 8 from San Antonio to Panama City, returning Tue, Jul 22, priced at $495 found 23 hours ago
Copa
Fri, Jul 4 - Wed, Jul 16
SAT
San Antonio
PTY
Panama City
$1,571 Roundtrip, just found
$1,571
Roundtrip
just found
Select Copa flight, departing Fri, Jul 4 from San Antonio to Panama City, returning Wed, Jul 16, priced at $1,571 just found
Flights from San Antonio (SAT) to Panama City (PTY)
Origin airport
San Antonio Intl.
Destination airport
Tocumen Intl.
Airlines serving
American Airlines, Copa, Delta, United
Roundtrip price
$479
Distance
1877 mi

San Antonio to Panama City Flights

The cheapest times to fly from San Antonio to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from San Antonio to Panama City are during the month of October. You can find some of the cheapest flights from San Antonio to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from San Antonio to Panama City

Sunday is one of the best days to book for cheap flights from San Antonio to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from San Antonio to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from San Antonio to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $227 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap San Antonio to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your San Antonio to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from San Antonio Intl. Airport (SAT) to Tocumen Intl. Airport (PTY) cost?
Discover the latest flight deals from SAT to PTY by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from SAT to PTY?
The cheapest flights from SAT to PTY are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from SAT to PTY?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from SAT to PTY. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from San Antonio Intl. Airport (SAT) to Tocumen Intl. Airport (PTY)?
You’ll need to hop on a flight with a layover if you’re traveling from San Antonio Intl. Airport (SAT) to Tocumen Intl. Airport (PTY). Direct flights don’t operate daily on this route. However, just filter your search to include one or two stops to find an option that works for you.
What day of the week has the most flights from SAT to PTY?
You’ll generally find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from San Antonio Intl. Airport (SAT) to Tocumen Intl. Airport (PTY)?
To avoid possible delays on the San Antonio Intl. Airport (SAT) to Tocumen Intl. Airport (PTY) route, aim to travel before 3 PM. Later flights are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from San Antonio Intl. Airport (SAT) to Tocumen Intl. Airport (PTY) last-minute?
Last-minute bookings from SAT to PTY are typically more expensive. To secure the cheapest rates, start looking for flights as early as possible. That said, if your travel plans are flexible, you may score a cheap fare right before your journey.
Is it cheaper to book a SAT to PTY flight and hotel package?
Compared with arranging flights and hotels separately, booking a SAT to PTY flight and hotel package with Expedia could lead to significant savings. Better yet, having it all in one place will take the hassle out of travel planning. Simply secure your flights and choose from our extensive range of hotels, then personalize your trip with extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from San Antonio Intl. Airport (SAT) to Tocumen Intl. Airport (PTY)?
Generally, it’s possible to reschedule or cancel your SAT to PTY flight. However, for bookings made more than 24 hours ago, additional fees may apply. Check your airline’s policies in your itinerary to see what changes are allowed and if any costs are involved. You’ll also find more details on our Customer Service portal.

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*Available to One Key members.