$134 Cheap Flights from Panama City (PTY) to Medellín (MDE)

View $134 flight on Tue, May 6, 2025Opens in a new window

Featured airlines

  • Plan, book, fly with confidence

  • trending down icon
    Be in the know
    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon
    Book smarter
    Save up to 30% on select hotels after you book a flight*
  • one key icon
    Earn twice
    Earn your airline miles on top of our OneKeyCash
    Learn about One Key
Find available prices by choosing your travel dates.

Cheap Flights from Panama City to Medellín (PTY-MDE)

Prices were available within the past 7 days and start at $134 for one-way flights and $250 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Thu, May 8 - Sat, May 10
PTY
Panama City
MDE
Medellin
$250 Roundtrip, found 1 hour ago
$250
Roundtrip
found 1 hour ago
Select Copa flight, departing Thu, May 8 from Panama City to Medellin, returning Sat, May 10, priced at $250 found 1 hour ago
Copa
Thu, May 8 - Sat, May 10
PTY
Panama City
MDE
Medellin
$260 Roundtrip, found 1 hour ago
$260
Roundtrip
found 1 hour ago
Select Copa flight, departing Thu, May 8 from Panama City to Medellin, returning Sat, May 10, priced at $260 found 1 hour ago
Copa
Sat, Jul 5 - Wed, Jul 9
PTY
Panama City
MDE
Medellin
$265 Roundtrip, found 1 hour ago
$265
Roundtrip
found 1 hour ago
Select Copa flight, departing Sat, Jul 5 from Panama City to Medellin, returning Wed, Jul 9, priced at $265 found 1 hour ago
Copa
Thu, May 8 - Sat, May 10
PTY
Panama City
MDE
Medellin
$274 Roundtrip, found 1 hour ago
$274
Roundtrip
found 1 hour ago
Select Copa flight, departing Thu, May 8 from Panama City to Medellin, returning Sat, May 10, priced at $274 found 1 hour ago
Copa
Sat, Jul 5 - Wed, Jul 9
PTY
Panama City
MDE
Medellin
$275 Roundtrip, found 1 hour ago
$275
Roundtrip
found 1 hour ago
Select Copa flight, departing Sat, Jul 5 from Panama City to Medellin, returning Wed, Jul 9, priced at $275 found 1 hour ago
Copa
Sat, Jul 5 - Wed, Jul 9
PTY
Panama City
MDE
Medellin
$282 Roundtrip, found 1 hour ago
$282
Roundtrip
found 1 hour ago
Select Copa flight, departing Sat, Jul 5 from Panama City to Medellin, returning Wed, Jul 9, priced at $282 found 1 hour ago
Copa
Thu, May 1 - Sat, May 10
PTY
Panama City
MDE
Medellin
$283 Roundtrip, found 7 hours ago
$283
Roundtrip
found 7 hours ago
Select Copa flight, departing Thu, May 1 from Panama City to Medellin, returning Sat, May 10, priced at $283 found 7 hours ago
Copa
Thu, May 8 - Sat, May 10
PTY
Panama City
MDE
Medellin
$285 Roundtrip, found 1 hour ago
$285
Roundtrip
found 1 hour ago
Select Copa flight, departing Thu, May 8 from Panama City to Medellin, returning Sat, May 10, priced at $285 found 1 hour ago
avianca
Wed, May 7 - Sat, May 10
PTY
Panama City
MDE
Medellin
$286 Roundtrip, just found
$286
Roundtrip
just found
Select avianca flight, departing Wed, May 7 from Panama City to Medellin, returning Sat, May 10, priced at $286 just found
Aeromexico
Sat, Oct 18 - Sat, Oct 25
PTY
Panama City
MDE
Medellin
$517 Roundtrip, found 1 day ago
$517
Roundtrip
found 1 day ago
Select Aeromexico flight, departing Sat, Oct 18 from Panama City to Medellin, returning Sat, Oct 25, priced at $517 found 1 day ago

Frequently asked questions

How much does a flight from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE) cost?
Cheap round-trip flights from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE) start at $265. This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a Copa flight leaving PTY on May 15 2025 and touching down at MDE. The price was last updated on April 22 2025 and has not changed since.
What is the cheapest month to fly from PTY to MDE?
The cheapest flights from PTY to MDE are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE)?
Hop on a nonstop flight with Copa Airlines and go straight from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE).
What is the cheapest airline that flies from PTY to MDE?
With prices starting from $142 for a one-way journey from PTY to MDE, Copa is currently the cheapest carrier operating this route. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from PTY on May 28 2025. Prices were last updated on April 22 2025 and have not changed since.
How many flights per day from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE)?
With an average of 9 nonstop flights that operate from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE) every day, you’ll be taking off on vacation soon enough.
What are the most popular departure times for flights from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE)?
Flights between PTY and MDE are their busiest at 9 AM. For a less crowded experience and possibly cheaper prices, look for a time when demand is lower.
What day of the week has the most flights from PTY to MDE?
Friday offers the most flights from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE). Consider jetting off on this day and you’ll have the best chance of finding a departure that fits your itinerary.
What is the earliest flight from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE)?
The first flight of the day taking off from Tocumen Intl. Airport (PTY) is at around 7:01AM UTC-5. Catch this flight and you’ll reach Jose Maria Cordova Intl. Airport (MDE) at approximately 8:23AM UTC-5. The entire trip takes 1h 22m.
How long does it take to fly from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE)?
Typically, it takes 1 hour and 22 minutes to cover the 340 mi from PTY to MDE.
What airline has the least delays from PTY to MDE?
Copa Airlines has the best performance for on-time direct flights from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE), with an on-time score of 92%. Use the Expedia App to view your flight status before you head off and get real-time alerts about any trip changes.
What is the best time to fly from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE)?
Opt for a flight from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE) that leaves before 3 PM to reduce the risk of delays and cancellations. Departures after this time have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
What airports do you fly into for Medellin from Tocumen Intl. Airport (PTY)?
Compare your flight options from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE). This is the only Medellin airport you can land at if you’re taking a direct flight.
Is it cheaper to buy a plane ticket from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE) last-minute?
Last-minute fares from PTY to MDE are typically more expensive. To lock in the best rates, start looking for flights early. That said, if you can play around with your travel dates, it’s possible to find a cheap fare right before your trip.
Is it cheaper to book a PTY to MDE flight and hotel package?
Opting for a PTY to MDE flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip in one place. Pick from our wide range of accommodations and then add flights, car rentals and activities to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE)?
If you reserved your PTY to MDE flight within the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal if you’d like more information.
*Available to One Key members.