$291 Cheap Flights from Guadalajara (GDL) to Des Moines (DSM)

View $291 flight on Fri, May 9, 2025Opens in a new window

Popular airlines from Don Miguel Hidalgo y Costilla Intl. Airport (GDL) to Des Moines International Airport (DSM)

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Find available prices by choosing your travel dates.

Cheap Flights from Guadalajara to Des Moines (GDL-DSM)

Prices were available within the past 7 days and start at $291 for one-way flights and $463 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Wed, May 7 - Fri, May 30
GDL
Guadalajara
DSM
Des Moines
$463 Roundtrip, found 2 days ago
$463
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Wed, May 7 from Guadalajara to Des Moines, returning Fri, May 30, priced at $463 found 2 days ago
United
Tue, May 6 - Tue, May 13
GDL
Guadalajara
DSM
Des Moines
$474 Roundtrip, found 23 hours ago
$474
Roundtrip
found 23 hours ago
Select United flight, departing Tue, May 6 from Guadalajara to Des Moines, returning Tue, May 13, priced at $474 found 23 hours ago
Delta
Tue, May 6 - Tue, May 13
GDL
Guadalajara
DSM
Des Moines
$474 Roundtrip, found 23 hours ago
$474
Roundtrip
found 23 hours ago
Select Delta flight, departing Tue, May 6 from Guadalajara to Des Moines, returning Tue, May 13, priced at $474 found 23 hours ago
Aeromexico
Tue, May 6 - Tue, May 13
GDL
Guadalajara
DSM
Des Moines
$474 Roundtrip, found 23 hours ago
$474
Roundtrip
found 23 hours ago
Select Aeromexico flight, departing Tue, May 6 from Guadalajara to Des Moines, returning Tue, May 13, priced at $474 found 23 hours ago
American Airlines
Tue, May 6 - Tue, May 13
GDL
Guadalajara
DSM
Des Moines
$474 Roundtrip, found 23 hours ago
$474
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Tue, May 6 from Guadalajara to Des Moines, returning Tue, May 13, priced at $474 found 23 hours ago
United
Tue, May 6 - Tue, May 13
GDL
Guadalajara
DSM
Des Moines
$479 Roundtrip, found 23 hours ago
$479
Roundtrip
found 23 hours ago
Select United flight, departing Tue, May 6 from Guadalajara to Des Moines, returning Tue, May 13, priced at $479 found 23 hours ago
Frontier Airlines
Wed, May 7 - Mon, May 19
GDL
Guadalajara
DSM
Des Moines
$481 Roundtrip, found 2 days ago
$481
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Wed, May 7 from Guadalajara to Des Moines, returning Mon, May 19, priced at $481 found 2 days ago
Frontier Airlines
Wed, May 7 - Wed, May 21
GDL
Guadalajara
DSM
Des Moines
$482 Roundtrip, found 2 days ago
$482
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Wed, May 7 from Guadalajara to Des Moines, returning Wed, May 21, priced at $482 found 2 days ago
American Airlines
Tue, May 6 - Tue, May 13
GDL
Guadalajara
DSM
Des Moines
$483 Roundtrip, found 23 hours ago
$483
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Tue, May 6 from Guadalajara to Des Moines, returning Tue, May 13, priced at $483 found 23 hours ago
United
Tue, May 6 - Tue, May 13
GDL
Guadalajara
DSM
Des Moines
$484 Roundtrip, found 23 hours ago
$484
Roundtrip
found 23 hours ago
Select United flight, departing Tue, May 6 from Guadalajara to Des Moines, returning Tue, May 13, priced at $484 found 23 hours ago
Flights from Guadalajara (GDL) to Des Moines (DSM)
Origin airport
Don Miguel Hidalgo y Costilla Intl.
Destination airport
Des Moines Intl.
Airlines serving
Aeromexico, American Airlines, Delta, United
Roundtrip price
$463
Distance
1557 mi

Guadalajara to Des Moines Flights

The cheapest times to fly from Guadalajara to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Guadalajara to Des Moines are during the month of May. You can find some of the cheapest flights from Guadalajara to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Guadalajara to Des Moines

Sunday is one of the best days to book for cheap flights from Guadalajara to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Guadalajara to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Guadalajara to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $291 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Guadalajara to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Guadalajara to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Don Miguel Hidalgo y Costilla Intl. Airport (GDL) to Des Moines Intl. Airport (DSM) cost?
Discover the latest flight deals from GDL to DSM by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from GDL to DSM?
The cheapest flights from GDL to DSM are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from GDL to DSM?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from GDL to DSM. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Don Miguel Hidalgo y Costilla Intl. Airport (GDL) to Des Moines Intl. Airport (DSM)?
There are no daily nonstop flights from Don Miguel Hidalgo y Costilla Intl. Airport (GDL) to Des Moines Intl. Airport (DSM). But you can book flights with layovers. Filter your search on Expedia to include one or two stops, and you’ll be on your way before you know it.
What day of the week has the most flights from GDL to DSM?
Usually you’ll find the greatest selection of flight options on a Friday. Tuesdays are often the quietest.* But this can change depending on the season, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Don Miguel Hidalgo y Costilla Intl. Airport (GDL) to Des Moines Intl. Airport (DSM)?
Select a flight from Don Miguel Hidalgo y Costilla Intl. Airport (GDL) to Des Moines Intl. Airport (DSM) that leaves before 3 PM to reduce the likelihood of delays and cancellations. Later departures have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Don Miguel Hidalgo y Costilla Intl. Airport (GDL) to Des Moines Intl. Airport (DSM) last-minute?
Booking your ticket from GDL to DSM just before your trip is typically more expensive. But if there’s some wiggle room with your departure dates and times, you could land a cheap last-minute fare.
Is it cheaper to book a GDL to DSM flight and hotel package?
Opting for a GDL to DSM flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Pick from our wide range of accommodations and then add car rentals, flights and activities to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Don Miguel Hidalgo y Costilla Intl. Airport (GDL) to Des Moines Intl. Airport (DSM)?
If you reserved your GDL to DSM flight in the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more information.

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*Available to One Key members.