21c Museum Hotel Louisville

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Luxury
4.5 star property
9.4

Exceptional

Art museum meets boutique retreat

Acclaimed restaurant Proof on Main serves phenomenal cuisine in an artsy atmosphere connected to the hotel's museum gallery. Guests can retreat to the full-service spa for rejuvenating massages. The downtown Louisville location puts museums, bourbon tours, and attractions within walking distance.

Popular amenities

  • Spa
  • Pet friendly
  • Free WiFi
  • Air conditioning
  • Gym

Room options

Available filters for rooms
Showing 12 of 12 rooms

View all photos for Deluxe Double Room, 2 Double Beds

A hotel room with two beds, a headboard with a framed artwork of birds, a bedside table with a lamp, and a small bookshelf.

Deluxe Double Room, 2 Double Beds

9.6 out of 10
Exceptional
(34 reviews)
  • 335 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Double Beds
  • Free wired internet

View all photos for Luxury Double Room, 2 Double Beds

A hotel room with two beds, a desk, a chair, a lamp, and a large window with a view.

Luxury Double Room, 2 Double Beds

  • City view
  • 435 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Double Beds
  • Free wired internet

View all photos for Deluxe Room, 1 King Bed

A hotel room with a bed, a desk, a chair, a lamp, a plant, and a TV on the wall.

Deluxe Room, 1 King Bed

9.6 out of 10
Exceptional
(79 reviews)
  • 350 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed
  • Free wired internet

View all photos for Luxury Room, 1 King Bed

A hotel room with a large bed, a chair, a desk, and a window with curtains.

Luxury Room, 1 King Bed

9.0 out of 10
Wonderful
(37 reviews)
  • City view
  • 455 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed
  • Free wired internet

View all photos for Suite, Corner

A modern living room with a grey sofa, a red decorative piece, a white armchair, and a dining area with a table and chairs.

Suite, Corner

  • City view
  • 660 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free wired internet

View all photos for Room (Asleep in the Cyclone)

A room with a geometric-patterned ceiling, a bed with a patterned bedspread, and a nightstand with a lamp.

Room (Asleep in the Cyclone)

  • 500 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free wired internet

View all photos for Suite (Atrium)

A hotel room with a bed, desk, chair, dresser, and a sofa.

Suite (Atrium)

  • 580 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free wired internet

View all photos for Room, Balcony

A hotel room with a large bed, a nightstand with a lamp, a chair, and a view of the outdoors.

Room, Balcony

10.0 out of 10
Exceptional
(1 review)
  • City view
  • 315 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free wired internet

View all photos for Deluxe Double Room, Accessible

A modern bathroom with a white sink, mirror, and toilet.

Deluxe Double Room, Accessible

9.0 out of 10
Wonderful
(2 reviews)
  • 455 sq ft
  • Sleeps 4
  • 2 Double Beds
  • Free wired internet

View all photos for Deluxe Room, 1 King Bed, Accessible

A hotel room with a large bed, two bedside tables with lamps, a wooden headboard, a large mirror, and a wall-mounted abstract art piece.

Deluxe Room, 1 King Bed, Accessible

10.0 out of 10
Exceptional
(2 reviews)
  • 434 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free wired internet

View all photos for Deluxe Room, 1 King Bed, Accessible

A hotel room with a large bed, two bedside tables with lamps, a wooden headboard, a large mirror, and a wall-mounted abstract art piece.

Deluxe Room, 1 King Bed, Accessible

10.0 out of 10
Exceptional
(1 review)
  • 435 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free wired internet

View all photos for Apartment, 1 Double Bed (Rooftop)

A modern interior with a dining area, a patterned bench, and a large window with a city view.

Apartment, 1 Double Bed (Rooftop)

10.0 out of 10
Exceptional
(1 review)
  • City view
  • Sleeps 4
  • 1 Double Bed
  • Free wired internet

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About the neighborhood

Located in Downtown Louisville, a neighborhood in Louisville, 21c Museum Hotel Louisville is near the airport and near theme parks. Louisville Mega Cavern and Evan Williams Bourbon Experience are worth checking out if an activity is on the agenda, while those in the mood for shopping can visit Fourth Street Live! and Nulu Market Place. Check out an event or a game at KFC Yum Center, and consider making time for Kentucky Kingdom, a top attraction not to be missed. Break out the clubs and hit the links with a golf course nearby, or seek out an adventure with hiking/biking trails. Visit our Louisville travel guide
Map
700 W Main Street, Louisville, KY, 40202

What's nearby

  • A modern building with a cylindrical structure and a glass facade.
    Muhammad Ali Center
    3 min walk - 0.2 miles
  • A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."
    Louisville Slugger Museum
    3 min walk - 0.2 miles
  • A river with a bridge, a stadium, and modern buildings.
    KFC Yum Center
    8 min walk - 0.5 miles
  • 21c Museum Hotel
    1 min walk - 0.1 miles
  • Kentucky International Convention Center
    8 min walk - 0.5 miles

Getting around

  • Louisville Intl. Airport (SDF)
    10 min drive

Restaurants

  • Thelma's Deli
    7 min walk
  • Steak And Bourbon
    7 min walk
  • Heine Brothers' Coffee
    3 min walk
  • Swizzle
    7 min walk
  • Loft At The Biscuit Lounge
    7 min walk

About this property

21c Museum Hotel Louisville

  • Luxury boutique hotel in the business district
  • Close to Kentucky International Convention Center and KFC Yum Center, 21c Museum Hotel Louisville provides dry cleaning/laundry services, a bar, and a 24-hour gym. Treat yourself to a hot stone massage at 21c Spa, the onsite spa. The on-site restaurant, Proof on Main, offers breakfast, brunch, lunch, and dinner. In addition to a 24-hour business center, guests can connect to free in-room WiFi.
  • You'll also enjoy perks such as:
    • Limo/town car service, full breakfast (surcharge), and valet parking (surcharge)
    • An electric car charging station, multilingual staff, and an elevator
    • Luggage storage, smoke-free premises, and a gift shop
    • Guest reviews speak highly of the dining options, helpful staff, and location
  • Room features
  • All 91 rooms include comforts such as premium bedding and laptop-compatible safes, in addition to perks like laptop-friendly workspaces and air conditioning. Guest reviews speak positively of the clean rooms at the property.
  • Extra conveniences in all rooms include:
    • LED light bulbs and eco-friendly cleaning products
    • Bathrooms with designer toiletries and hair dryers
    • 50-inch HDTVs with premium channels
    • Wardrobes/closets, free infant beds, and daily housekeeping

Awards and affiliations

  • Sustainability Certifications
  • This property is certified by this third-party sustainability certification scheme: Green Key Global. For more information on what this certification requires and verifies, please visit their website.

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Property amenities

Internet

  • Available in all rooms: Free WiFi and wired internet
  • Available in some public areas: Free WiFi and wired internet

Parking and transportation

  • Electric car charging station on site
  • Limo/town car service
  • Valet parking on site (USD 32 per night; includes in/out privileges)
  • Wheelchair-accessible parking available

Food and drink

  • Full breakfast available for a fee 7:00 AM to 10:00 AM on weekdays and 8:00 AM to 1:00 PM on weekends; USD 5 to 25 per person
  • A bar/lounge
  • A restaurant
  • Coffee and tea in common areas

Restaurants on site

  • Proof on Main

Things to do

  • 24-hour gym
  • Full-service spa
  • Yoga classes

Family friendly

  • In-room crib
  • Laundry facilities
  • Rollaway/extra bed (surcharge)
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Gift shop/newsstand
  • Laundry facilities
  • Luggage storage
  • Safe at front desk

Guest services

  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)
  • Multilingual staff
  • Porter/bellhop
  • Tour and ticket assistance

Business services

  • 24-hour business center
  • 5,000 square feet of conference space
  • Computer station
  • Meeting rooms

Full-service spa

  • 2 treatment rooms
  • Deep-tissue massages
  • Hot stone massages
  • In-room massages
  • Prenatal massages
  • Sauna
  • Spa open daily
  • Sports massages
  • Steam room
  • Swedish massages

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Assistive listening devices
  • Braille/raised signage
  • Elevator
  • Wheelchair accessibility
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible registration desk

More

  • 1 building
  • 4 floors
  • Banquet hall
  • Built in 2006
  • Comprehensive food waste policy
  • Double-glazed windows
  • Eco-friendly cleaning products used
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Non-plastic coffee stirrers available
  • Non-plastic drinking straws available
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed
  • Some LED lighting used
  • Vegan dining options

Room amenities

Bedroom

  • Blackout drapes
  • Down comforter
  • Free crib
  • Hypo-allergenic bedding
  • Premium bedding
  • Rollaway/extra bed (surcharge)

Bathroom

  • Bathrobes
  • Designer toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • 50-inch LCD TV with premium cable channels
  • iPod dock

Food and drink

  • Champagne service
  • Espresso maker
  • Free bottled water
  • Limited room service
  • Minibar

More

  • Air conditioning (climate-controlled)
  • Cleaning products are eco-friendly
  • Connecting rooms available
  • Desk
  • Eco-friendly toiletries
  • Free local calls
  • Iron/ironing board
  • Laptop workspace
  • Laptop-compatible safe
  • LED lighting
  • Soundproofed rooms
  • Water-efficient showers

Policies

Check-in

Check-in start time: 4 PM; Check-in end time: midnight
Contactless check-in available
Minimum check-in age: 21

Check-out

Check-out before 11 AM
Contactless check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets allowed for an extra charge of USD 40.00 per accommodation, per stay
Service animals are welcome, and are exempt from fees
Up to 50 lbs per pet
Food and water bowls are available

Children and extra beds

Children are welcome
Rollaway/extra beds are available for USD 30.0 per night
Free cribs are available on request at the property

Property payment types

American ExpressDiscoverMastercardVisa

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Service fee: USD 5.00 per accommodation, per stay

We have included all charges provided to us by the property.

Optional extras

  • Fee for full breakfast: approximately USD 5 to 25 per person
  • Valet parking fee: USD 32 per night (in/out privileges)
  • Pet fee: USD 40.00 per accommodation, per stay
  • Service animals are exempt from fees
  • Rollaway bed fee: USD 30.0 per night

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards; cash is not accepted
Safety features at this property include a carbon monoxide detector, a fire extinguisher, a smoke detector, a security system, a first aid kit, and window guards
This property affirms that it follows the cleaning and disinfection practices of ALLSAFE (Accor Hotels)

We should mention

Reservations are required for massage services; reservations can be made by contacting the property prior to arrival, using the contact information on the booking confirmation
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Frequently asked questions

Is 21c Museum Hotel Louisville pet-friendly?

Yes, this hotel allows pets with a maximum weight of up to 50 lbs per pet. There's a fee of USD 40.00 per accommodation, per stay. Service animals are exempt from fees.

How much does it cost to stay at 21c Museum Hotel Louisville?

As of Sep 23, 2026, prices found for a 1-night stay for 2 adults at 21c Museum Hotel Louisville on Oct 18, 2026 start from $234, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

How much is parking?

Valet parking is available for USD 32 per night.

What time is check-in at 21c Museum Hotel Louisville?

Check-in start time: 4 PM; Check-in end time: midnight.

What time is check-out at 21c Museum Hotel Louisville?

Check-out is at 11 AM.

Where is 21c Museum Hotel Louisville located?

Located in Downtown Louisville, this luxury hotel is within a 10-minute walk of Ohio River Valley, KFC Yum Center, and Whiskey Row. 21c Museum Hotel and Louisville Science Center are just steps away.

Can I cancel my reservation for free and receive a full refund?

Yes, this property offers free cancellation on select room rates, because flexibility matters! Please refer to the property cancellation policy on our site for more details about any exclusions or requirements.

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Reviews

21c Museum Hotel Louisville Reviews

9.4

Exceptional

9.6

Cleanliness

9.0

Amenities

9.4

Staff & service

9.6

Property conditions & facilities
Rating 10 - Excellent. 786 out of 1000 reviews
Rating 8 - Good. 119 out of 1000 reviews
Rating 6 - Okay. 59 out of 1000 reviews
Rating 4 - Poor. 19 out of 1000 reviews
Rating 2 - Terrible. 17 out of 1000 reviews

Reviews

Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
It was a great stay! The room and location were perfect, and the staff were very accommodating!
Stayed 4 nights in Aug 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great staff!
Stayed 1 night in Aug 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
It’s beautiful and unique; also well situated….
Stayed 1 night in Aug 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beautiful property, on-site restaurant was delicious. Beds very nice.
Stayed 1 night in Jul 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Convenient location.
Stayed 2 nights in Jul 2026
Verified review

2/10 Terrible

Liked: Cleanliness, property conditions & facilities
Disliked: Staff & service, amenities
The beds were comfortable on the front desk. Staff was great other than that not a place to host a venue at all.
Stayed 2 nights in Jul 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, property conditions & facilities
Mini fridge in room is full of paid items. No room to store any left overs or drinks. Otherwise everything was very nice. Clean room and rr, water pressure was great, museum was a nice spot to wander around and learn a bit. Easy in and out.
Stayed 1 night in Sep 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The hotel is quite unique with the art displayed throughout and the rooms are very well appointed with comfortable beds
Stayed 2 nights in Jun 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Loved this hotel and museum. Really enjoyed leisurely walking the museum with a bourbon in hand!
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very cool hotel with an art studio within it. Great staff. Great location. Great room and amenities.
Stayed 1 night in Jun 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Lovely experience, room was beautiful, clean, comfortable; staff was welcoming. Hotel was just lovely. We would definitely go back and highly recommend it to other travelers.
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Stayed there for thunder and it was so pleasant! Quiet and comfortable. All staff was very helpful and the cleanliness of the entire hotel was amazing!
Stayed 1 night in Apr 2026
Verified review

10/10 Excellent

Liked: Cleanliness, amenities, property conditions & facilities
Nice room and close to all the distilleries. Great restaurant on site as well!
Stayed 1 night in Feb 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great hotel And staff. Will come. Back
Stayed 2 nights in Jun 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great museum themed hotel with character. The rooms were spacious and comfortable. Also located right of bourbon row which makes it easy to get around town. The valet service and staff were courteous and helpful. They can also charge your electric vehicle, which is included with your stay, while the car is parked.
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Unique venue with some many amenities. Staff are super helpful and hospital. Will stay again when I’m in town.
Stayed 1 night in Apr 2026
Verified review

10/10 Excellent

Liked: Cleanliness, amenities, property conditions & facilities
Large spacious room and super comfortable bed Fascinating art and super bar and restaurant too Great service from all staff
Stayed 2 nights in Feb 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very clean and beautiful artwork, friendly I was surprised in the morning with valet parking with them overnight cane surprise charge if my Tesla , which is wonderful
Stayed 1 night in Jun 2026
Verified review

10/10 Excellent

Liked: Cleanliness, amenities, property conditions & facilities
Great room, super kind staff
Stayed 2 nights in Feb 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very clean and quiet room
Stayed 1 night in Apr 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The rooms and staff were great and the penguins were alive.
Stayed 1 night in Feb 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
21C is by far the best hotel we’ve ever stayed in. The museum is fantastic! The entire Staff went above and beyond for us.
Stayed 1 night in Apr 2026
Verified review

10/10 Excellent

Interesting Ambiente, very knowledgeable and friendly staff, great bar and good food in the restaurant with special choices.
Stayed 2 nights in Feb 2026
Verified review

10/10 Excellent

Liked: Cleanliness, amenities, property conditions & facilities
Clean room, art work is beautiful, friendly staff .
Stayed 1 night in Jan 2026
Verified review

8/10 Good

Liked: Cleanliness, amenities, property conditions & facilities
Great location for Whiskey Row in Downtown Louisville. Hotel was clean, artsy and has a great restaurant on site.
Stayed 2 nights in Jan 2026