Skip to main content

21c Museum Hotel Louisville

Choose dates to view prices

Luxury
4.5 star property
9.4

Exceptional

Art museum meets boutique retreat

Acclaimed restaurant Proof on Main serves phenomenal cuisine in an artsy atmosphere connected to the hotel's museum gallery. Guests can retreat to the full-service spa for rejuvenating massages. The downtown Louisville location puts museums, bourbon tours, and attractions within walking distance.

Popular amenities

  • Spa
  • Pet friendly
  • Free WiFi
  • Air conditioning
  • Gym

Room options

Available filters for rooms
Showing 12 of 12 rooms

View all photos for Deluxe Double Room, 2 Double Beds

A modern bathroom with a white sink, mirror, and toilet.

Deluxe Double Room, 2 Double Beds

9.6 out of 10
Exceptional
(34 reviews)
  • 335 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Double Beds
  • Free WiFi

View all photos for Luxury Double Room, 2 Double Beds

A hotel room with two beds, a desk, a chair, a window with curtains, and a wall with bird artwork.

Luxury Double Room, 2 Double Beds

9.0 out of 10
Wonderful
(2 reviews)
  • City view
  • 435 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Double Beds
  • Free WiFi

View all photos for Deluxe Room, 1 King Bed

A hotel room with a large bed, two bedside tables with lamps, a wooden headboard, a large mirror, and a wall-mounted abstract art piece.

Deluxe Room, 1 King Bed

9.6 out of 10
Exceptional
(78 reviews)
  • 350 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed
  • Free WiFi

View all photos for Luxury Room, 1 King Bed

A modern bathroom with a white sink, mirror, and toilet.

Luxury Room, 1 King Bed

9.0 out of 10
Wonderful
(36 reviews)
  • City view
  • 455 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed
  • Free WiFi

View all photos for Suite, Corner

A hotel room with a large bed, a TV mounted on the wall, a desk with a lamp, and a view of the city through large windows.

Suite, Corner

  • City view
  • 660 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free WiFi

View all photos for Room (Asleep in the Cyclone)

A cozy room with a geometric-patterned ceiling, a sofa, and a chair.

Room (Asleep in the Cyclone)

  • 500 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free WiFi

View all photos for Suite (Atrium)

A hotel room with a large bed, a desk, a chair, a red sculpture, a TV, and a painting on the wall.

Suite (Atrium)

  • 580 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free WiFi

View all photos for Room, Balcony

A rooftop terrace with a round table, wicker chairs, a red sculpture, and a view of city buildings.

Room, Balcony

10.0 out of 10
Exceptional
(1 review)
  • City view
  • 315 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free WiFi

View all photos for Deluxe Double Room, Accessible

A modern bathroom with a white sink, mirror, and toilet.

Deluxe Double Room, Accessible

9.0 out of 10
Wonderful
(2 reviews)
  • 455 sq ft
  • Sleeps 4
  • 2 Double Beds
  • Free WiFi

View all photos for Deluxe Room, 1 King Bed, Accessible

A hotel room with a large bed, two bedside tables with lamps, a wooden headboard, a large mirror, and a wall-mounted abstract art piece.

Deluxe Room, 1 King Bed, Accessible

10.0 out of 10
Exceptional
(2 reviews)
  • 434 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free WiFi

View all photos for Deluxe Room, 1 King Bed, Accessible

A hotel room with a large bed, two bedside tables with lamps, a wooden headboard, a large mirror, and a wall-mounted abstract art piece.

Deluxe Room, 1 King Bed, Accessible

10.0 out of 10
Exceptional
(1 review)
  • 435 sq ft
  • Sleeps 3
  • 1 King Bed
  • Free WiFi

View all photos for Apartment, 1 Double Bed (Rooftop)

A hotel room with a large bed, a striped armchair, a nightstand with a lamp, and wall art including framed pictures and a painting of onions.

Apartment, 1 Double Bed (Rooftop)

10.0 out of 10
Exceptional
(1 review)
  • City view
  • Sleeps 4
  • 1 Double Bed
  • Free WiFi

You may also like

Ad
Lobby lounge

Omni Louisville Hotel

Downtown Louisville
  • Pool
  • Hot tub
  • Spa
  • Pet friendly
9.4 out of 10, Exceptional, 2,104 reviews
$196 nightly
The price is $231
Sep 5 - Sep 6
Total with taxes and fees
Omni Louisville Hotel
Mod logo
Earn OneKeyCash on thousands of hotels when you sign in and book. More rewards for more adventures!
Sign inSign up, it's free

About the neighborhood

Located in Downtown Louisville, a neighborhood in Louisville, 21c Museum Hotel Louisville is near the airport and near theme parks. Whiskey Row is a notable landmark and some of the area's popular attractions include Louisville Slugger Museum and Kentucky Kingdom. Looking to enjoy an event or a game? See what's going on at KFC Yum Center or Churchill Downs. Practice your golf swing on a nearby course, or enjoy other activities in the great outdoors, such as hiking/biking trails in the area. Visit our Louisville travel guide
Map
700 W Main Street, Louisville, KY, 40202

What's nearby

  • A modern building with a cylindrical structure and a glass facade.
    Muhammad Ali Center
    3 min walk - 0.2 miles
  • A wall of wooden baseball bats organized by size and weight.
    Louisville Slugger Museum
    3 min walk - 0.2 miles
  • A river with a bridge, a stadium, and modern buildings.
    KFC Yum Center
    8 min walk - 0.5 miles
  • 21c Museum Hotel
    1 min walk - 0.1 miles
  • Kentucky International Convention Center
    8 min walk - 0.5 miles

Getting around

  • Louisville Intl. Airport (SDF)
    10 min drive

Restaurants

  • Thelma's Deli
    7 min walk
  • Steak And Bourbon
    7 min walk
  • Heine Brothers' Coffee
    3 min walk
  • Swizzle
    7 min walk
  • The Conservatory Bar
    8 min walk

About this property

21c Museum Hotel Louisville

  • Luxury boutique hotel in the business district
  • Close to Louisville Slugger Museum and Kentucky International Convention Center, 21c Museum Hotel Louisville provides dry cleaning/laundry services, a bar, and a 24-hour gym. Treat yourself to a deep-tissue massage at 21c Spa, the onsite spa. The on-site restaurant, Proof on Main, offers breakfast, brunch, lunch, and dinner. In addition to a 24-hour business center, guests can connect to free in-room WiFi.
  • You'll also enjoy perks such as:
    • Limo/town car service, full breakfast (surcharge), and valet parking (surcharge)
    • An electric car charging station, luggage storage, and tour/ticket assistance
    • A computer station, coffee/tea in the lobby, and ATM/banking services
    • Guest reviews speak highly of the dining options, helpful staff, and location
  • Room features
  • All 91 rooms include comforts such as premium bedding and laptop-compatible safes, in addition to perks like laptop-friendly workspaces and air conditioning. Guest reviews speak positively of the clean rooms at the property.
  • Extra conveniences in all rooms include:
    • LED light bulbs and eco-friendly cleaning products
    • Bathrooms with designer toiletries and hair dryers
    • 50-inch HDTVs with premium channels
    • Wardrobes/closets, free infant beds, and daily housekeeping

Awards and affiliations

  • Sustainability Certifications
  • This property is certified by this third-party sustainability certification scheme: Green Key Global. For more information on what this certification requires and verifies, please visit their website.

Similar properties

Lobby
The Brown Hotel
Downtown Louisville
  • Free WiFi
  • Restaurant
  • Air conditioning
  • Gym
9.4 out of 10, Exceptional, 1,293 reviews
$146 nightly
The price is $172
Sep 4 - Sep 5
Total with taxes and fees
The Brown Hotel
Compare similar properties

Property amenities

Internet

  • Available in all rooms: Free WiFi and wired internet
  • Available in some public areas: Free WiFi and wired internet

Parking and transportation

  • Electric car charging station on site
  • Limo/town car service
  • Valet parking on site (USD 32 per night; includes in/out privileges)
  • Wheelchair-accessible parking available

Food and drink

  • Full breakfast available for a fee 7:00 AM to 10:00 AM on weekdays and 8:00 AM to 1:00 PM on weekends; USD 5 to 25 per person
  • A bar/lounge
  • A restaurant
  • Coffee and tea in common areas

Restaurants on site

  • Proof on Main

Things to do

  • 24-hour gym
  • Full-service spa
  • Yoga classes

Family friendly

  • In-room crib
  • Laundry facilities
  • Rollaway/extra bed (surcharge)
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Gift shop/newsstand
  • Laundry facilities
  • Luggage storage
  • Safe at front desk

Guest services

  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)
  • Multilingual staff
  • Porter/bellhop
  • Tour and ticket assistance

Business services

  • 24-hour business center
  • 5,000 square feet of conference space
  • Computer station
  • Meeting rooms

Full-service spa

  • 2 treatment rooms
  • Deep-tissue massages
  • Hot stone massages
  • In-room massages
  • Prenatal massages
  • Sauna
  • Spa open daily
  • Sports massages
  • Steam room
  • Swedish massages

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Assistive listening devices
  • Braille/raised signage
  • Elevator
  • Wheelchair accessibility
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible registration desk

More

  • 1 building
  • 4 floors
  • Banquet hall
  • Built in 2006
  • Comprehensive food waste policy
  • Double-glazed windows
  • Eco-friendly cleaning products used
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Non-plastic coffee stirrers available
  • Non-plastic drinking straws available
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed
  • Some LED lighting used
  • Vegan dining options

Room amenities

Bedroom

  • Blackout drapes
  • Down comforter
  • Free crib
  • Hypo-allergenic bedding
  • Premium bedding
  • Rollaway/extra bed (surcharge)

Bathroom

  • Bathrobes
  • Designer toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • 50-inch LCD TV with premium cable channels
  • iPod dock

Food and drink

  • Champagne service
  • Espresso maker
  • Free bottled water
  • Limited room service
  • Minibar

More

  • Air conditioning (climate-controlled)
  • Cleaning products are eco-friendly
  • Connecting rooms available
  • Desk
  • Eco-friendly toiletries
  • Free local calls
  • Iron/ironing board
  • Laptop workspace
  • Laptop-compatible safe
  • LED lighting
  • Soundproofed rooms
  • Water-efficient showers

Policies

Check-in

Check-in start time: 4 PM; Check-in end time: midnight
Contactless check-in available
Minimum check-in age: 21

Check-out

Check-out before 11 AM
Contactless check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets allowed for an extra charge of USD 40.00 per accommodation, per stay
Service animals are welcome, and are exempt from fees
Up to 50 lbs per pet
Food and water bowls are available

Children and extra beds

Children are welcome
Rollaway/extra beds are available for USD 30.0 per night
Free cribs are available on request at the property

Property payment types

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Service fee: USD 5.00 per accommodation, per stay

We have included all charges provided to us by the property.

Optional extras

  • Fee for full breakfast: approximately USD 5 to 25 per person
  • Valet parking fee: USD 32 per night (in/out privileges)
  • Pet fee: USD 40.00 per accommodation, per stay
  • Service animals are exempt from fees
  • Rollaway bed fee: USD 30.0 per night

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards; cash is not accepted
Safety features at this property include a carbon monoxide detector, a fire extinguisher, a smoke detector, a security system, a first aid kit, and window guards
This property affirms that it follows the cleaning and disinfection practices of ALLSAFE (Accor Hotels)

We should mention

Reservations are required for massage services; reservations can be made by contacting the property prior to arrival, using the contact information on the booking confirmation
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Frequently asked questions

Is 21c Museum Hotel Louisville pet-friendly?

Yes, this hotel allows pets with a maximum weight of up to 50 lbs per pet. There's a fee of USD 40.00 per accommodation, per stay. Service animals are exempt from fees.

How much does it cost to stay at 21c Museum Hotel Louisville?

As of Sep 2, 2026, prices found for a 1-night stay for 2 adults at 21c Museum Hotel Louisville on Sep 4, 2026 start from $216, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

How much is parking?

Valet parking is available for USD 32 per night.

What time is check-in at 21c Museum Hotel Louisville?

Check-in start time: 4 PM; Check-in end time: midnight.

What time is check-out at 21c Museum Hotel Louisville?

Check-out is at 11 AM.

Where is 21c Museum Hotel Louisville located?

Located in Downtown Louisville, this luxury hotel is steps from Ohio River Valley and Louisville Slugger Museum. KFC Yum Center and Whiskey Row are also within 10 minutes.

Can I cancel my reservation for free and receive a full refund?

Yes, this property offers free cancellation on select room rates, because flexibility matters! Please refer to the property cancellation policy on our site for more details about any exclusions or requirements.

Have a question?

AI iconBeta

Get instant answers with AI powered search of property information and reviews.