Skip to main content

21c Museum Hotel Louisville

Choose dates to view prices

Luxury
4.5 star property
9.4

Exceptional

Art museum meets boutique retreat

Acclaimed restaurant Proof on Main serves phenomenal cuisine in an artsy atmosphere connected to the hotel's museum gallery. Guests can retreat to the full-service spa for rejuvenating massages. The downtown Louisville location puts museums, bourbon tours, and attractions within walking distance.

Popular amenities

  • Spa
  • Pet friendly
  • Free WiFi
  • Air conditioning
  • Gym

You may also like

Ad

Omni Louisville Hotel

Downtown Louisville
  • Pool
  • Hot tub
  • Spa
  • Pet friendly
9.4 out of 10, Exceptional, 1,889 reviews
$179 nightly
The price is $211
Jun 2 - Jun 3
Total with taxes and fees
Omni Louisville Hotel
Mod logo
Earn OneKeyCash on thousands of hotels when you sign in and book. More rewards for more adventures!
Sign inSign up, it's free

About this property

21c Museum Hotel Louisville

  • Luxury boutique hotel near Louisville Slugger Museum
  • Close to Kentucky International Convention Center and KFC Yum Center, 21c Museum Hotel Louisville provides dry cleaning/laundry services, a bar, and a 24-hour gym. Treat yourself to a Swedish massage at 21c Spa, the onsite spa. The on-site restaurant, Proof on Main, offers breakfast, brunch, lunch, and dinner. In addition to a 24-hour business center, guests can connect to free in-room WiFi.
  • You'll also enjoy perks such as:
    • Limo/town car service, full breakfast (surcharge), and valet parking (surcharge)
    • An electric car charging station, a 24-hour front desk, and an elevator
    • Luggage storage, smoke-free premises, and a front-desk safe
    • Guest reviews speak highly of the dining options, helpful staff, and location
  • Room features
  • All 91 rooms include comforts such as premium bedding and laptop-compatible safes, in addition to perks like laptop-friendly workspaces and air conditioning. Guest reviews speak positively of the clean rooms at the property.
  • Extra conveniences in all rooms include:
    • LED light bulbs and eco-friendly cleaning products
    • Bathrooms with designer toiletries and hair dryers
    • 50-inch HDTVs with premium channels
    • Wardrobes/closets, free infant beds, and daily housekeeping

Awards and affiliations

  • Eco-Certified Property
  • This property participates in Green Key Global, a program that measures the property's impact on one or more of the following: environment, community, cultural-heritage, the local economy.

Similar properties

4 restaurants; breakfast, lunch, and dinner served
Galt House Hotel Trademark Collection by Wyndham
Downtown Louisville
  • Pool
  • Spa
  • Pet friendly
  • Free WiFi
9.0 out of 10, Wonderful, 4,184 reviews
$130 nightly
The price is $153
Jun 7 - Jun 8
Total with taxes and fees
Galt House Hotel Trademark Collection by Wyndham
Compare similar properties

Policies

Check-in

Check-in start time: 4 PM; Check-in end time: midnight

Contactless check-in available

Minimum check-in age: 21

Check-out

Check-out before 11 AM

Contactless check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets allowed for an extra charge of USD 40.00 per accommodation, per stay

Service animals are welcome, and are exempt from fees

Up to 50 lbs per pet

Food and water bowls are available

Children and extra beds

Children are welcome

Rollaway/extra beds are available for USD 30.0 per night

Free cribs are available on request at the property

Property payment types

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Service fee: USD 5.00 per accommodation, per stay

We have included all charges provided to us by the property.

Optional extras

  • Fee for full breakfast: approximately USD 5 to 25 per person
  • Valet parking fee: USD 32 per night (in/out privileges)
  • Pet fee: USD 40.00 per accommodation, per stay
  • Service animals are exempt from fees
  • Rollaway bed fee: USD 30.0 per night

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards; cash is not accepted
Safety features at this property include a carbon monoxide detector, a fire extinguisher, a smoke detector, a security system, a first aid kit, and window guards
This property affirms that it follows the cleaning and disinfection practices of ALLSAFE (Accor Hotels)

We should mention

Reservations are required for massage services; reservations can be made by contacting the property prior to arrival, using the contact information on the booking confirmation
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Frequently asked questions

Is 21c Museum Hotel Louisville pet-friendly?

Yes, this hotel allows pets with a maximum weight of up to 50 lbs per pet. There's a fee of USD 40.00 per accommodation, per stay. Service animals are exempt from fees.

How much does it cost to stay at 21c Museum Hotel Louisville?

As of May 24, 2026, prices found for a 1-night stay for 2 adults at 21c Museum Hotel Louisville on Jun 14, 2026 start from $184, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

How much is parking?

Valet parking is available for USD 32 per night.

What time is check-in at 21c Museum Hotel Louisville?

Check-in start time: 4 PM; Check-in end time: midnight.

What time is check-out at 21c Museum Hotel Louisville?

Check-out is at 11 AM.

Where is 21c Museum Hotel Louisville located?

Located in Downtown Louisville, this luxury hotel is steps from Ohio River Valley and Louisville Slugger Museum. Kentucky International Convention Center and KFC Yum Center are also within 15 minutes.

Can I cancel my reservation for free and receive a full refund?

Yes, this property offers free cancellation on select room rates, because flexibility matters! Please refer to the property cancellation policy on our site for more details about any exclusions or requirements.

Have a question?

AI iconBeta

Get instant answers with AI powered search of property information and reviews.

Reviews

Reviews

9.4

Exceptional

9.6

Cleanliness

9.0

Amenities

9.4

Staff & service

9.6

Property conditions & facilities
Rating 10 - Excellent. 773 out of 1002 reviews
Rating 8 - Good. 129 out of 1002 reviews
Rating 6 - Okay. 62 out of 1002 reviews
Rating 4 - Poor. 20 out of 1002 reviews
Rating 2 - Terrible. 18 out of 1002 reviews

Reviews

Verified

10/10 Excellent

Jason

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Unique venue with some many amenities. Staff are super helpful and hospital. Will stay again when I’m in town.
Stayed 1 night in Apr 2026
Verified

10/10 Excellent

Brent

Liked: Cleanliness, amenities, property conditions & facilities
Nice room and close to all the distilleries. Great restaurant on site as well!
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Tamara

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
21C is by far the best hotel we’ve ever stayed in. The museum is fantastic! The entire Staff went above and beyond for us.
Stayed 1 night in Apr 2026
Verified

6/10 Okay

Regina

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Room was clean, location was good. Homeless people sleeping right outside of the doorway doesn’t give the hotel the best vibe. Restaurant on site was just okay. Walls are pretty thin.
Stayed 2 nights in Apr 2026
Verified

10/10 Excellent

Amanada

Liked: Cleanliness, amenities, property conditions & facilities
Large spacious room and super comfortable bed Fascinating art and super bar and restaurant too Great service from all staff
Stayed 2 nights in Feb 2026
Verified

10/10 Excellent

MARC

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The rooms and staff were great and the penguins were alive.
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Rachel

Liked: Cleanliness, amenities, property conditions & facilities
Great room, super kind staff
Stayed 2 nights in Feb 2026
Verified

10/10 Excellent

Michael

Interesting Ambiente, very knowledgeable and friendly staff, great bar and good food in the restaurant with special choices.
Stayed 2 nights in Feb 2026
Verified

10/10 Excellent

Jeannie

Liked: Cleanliness, amenities, property conditions & facilities
Clean room, art work is beautiful, friendly staff .
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Susan

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very clean. A unique experience.
Stayed 3 nights in Apr 2026
Verified

8/10 Good

Stacy

Liked: Cleanliness, amenities, property conditions & facilities
Great location for Whiskey Row in Downtown Louisville. Hotel was clean, artsy and has a great restaurant on site.
Stayed 2 nights in Jan 2026
Verified

10/10 Excellent

Lorie

Liked: Cleanliness, staff & service, amenities
All the staff were great! The rooms were clean the coffee was great. I would stay here again.
Stayed 2 nights in Jan 2026
Verified

10/10 Excellent

Tammy

Liked: Cleanliness, amenities, property conditions & facilities
Staff was very kind, the art was fantastic, location was perfect to explore Whiskey Row, and we had a gorgeous room. Loved our time away there!
Stayed 1 night in Dec 2025
Verified

10/10 Excellent

Barbara

Liked: Cleanliness, amenities, property conditions & facilities
Staff very helpful. Rooms are spacious and clean. Lobby exhibits unique and interesting. Hotel well situated in downtown to access popular tourist attractions. Enjoyed our stay.
Stayed 3 nights in Jan 2026
Verified

8/10 Good

Tamara

Liked: Cleanliness, amenities, property conditions & facilities
Room was clean. The staff is helpful, nice, welcoming. Loved the art. Room is large. Great area.
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Lee Anne

Liked: Cleanliness, amenities, property conditions & facilities
Really interesting setting for a hotel with all of the artwork. The room was clean and comfortable. We would have appreciated softer towels.
Stayed 2 nights in Jan 2026
Verified

10/10 Excellent

david

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Beautiful environment Helpful friendly staff
Stayed 1 night in Nov 2025
Verified

10/10 Excellent

Jennifer

Liked: Cleanliness, staff & service, property conditions & facilities
Room was very clean and staff were very friendly.
Stayed 1 night in Sep 2025
Verified

10/10 Excellent

Clark and Margaret

Liked: Cleanliness, amenities, property conditions & facilities
Room clean , comfortable and quiet.
Stayed 1 night in Nov 2025
Verified

10/10 Excellent

Jennifer

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Amazing location and great hotel. Staff was great. Restaurant was delicious. Great location on Main Street!!
Stayed 4 nights in Sep 2025
Verified

10/10 Excellent

Robin

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
21c Museum Hotel is a fun and unique experience. Beautiful rooms and centrally located to shops, restaurants and distilleries in Louisville.
Stayed 2 nights in Oct 2025
Verified

10/10 Excellent

Kevin

Liked: Cleanliness, staff & service, amenities
The room was great! The bar was fantastic. The hotel accommodated all of my requests. My husband and I have stayed here a few times. I'm truly grateful for the kindness of the staff.
Stayed 1 night in Dec 2025
Verified

10/10 Excellent

earl

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Perfect location for walking Louisville
Stayed 4 nights in Oct 2025
Verified

10/10 Excellent

Ilya

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Great location, comfy beds, great service
Stayed 2 nights in Jun 2025
Verified

10/10 Excellent

Kimberley

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Fun place to stay! Eclectic, unique and eccentric decor. Really enjoyed the location and convenient, walkable access.
Stayed 3 nights in Sep 2025