489 Properties in Durham, North Carolina, United States of America. January 5, 2026 through January 6, 2026

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A hotel entrance with a glass facade, a flagpole, and a person standing in front.

A modern elevator lobby with marble walls, a bench, and a central elevator with a colorful door.

21c Museum Hotel Durham

Downtown Durham

8.48.4 out of 10

Very Goodvery good

1,004 reviews(1,004 reviews)

$134 nightly

The current price is $157 total

$157 total

Total with taxes and fees

We have 1 left at this price

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A modern reception area with a reception desk, a seating area with chairs and a table, and a bookshelf with books.

A long, narrow hallway with dark walls and wooden flooring.

University Inn Durham next to Duke University Medical Center

Durham

Fully refundable

Reserve now, pay later

9.09.0 out of 10

Wonderfulwonderful

1,002 reviews(1,002 reviews)

$6 off

$118 nightly

The current price is $134 total

$134 total

Total with taxes and fees

We have 3 left at this price

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A reception area with a wooden reception desk, blue seating, a flat-screen TV, and a stone accent wall.

A hotel room with a bed, a desk, a chair, a small table, a coffee machine, and a trash bin.

Comfort Inn & Suites Durham near Duke University

Durham

Breakfast included
Pool

8.68.6 out of 10

Excellentexcellent

1,127 reviews(1,127 reviews)

$93 nightly

The current price is $105 total

$105 total

Total with taxes and fees

We have 1 left at this price

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Photo gallery for 21c Museum Hotel Durham

21c Museum Hotel Durham

Photo gallery for University Inn Durham next to Duke University Medical Center

University Inn Durham next to Duke University Medical Center

Photo gallery for Comfort Inn & Suites Durham near Duke University

Comfort Inn & Suites Durham near Duke University