21C Museum Hotel St Louis

Luxury hotel with a fitness center and a steam room

Choose dates to view prices

Where to?

Dates

October 2025

23

November 2025

Interior - 21C Museum Hotel St Louis (St. Louis)

Business center - 21C Museum Hotel St Louis (St. Louis)

1 bedroom, in-room safe, desk, laptop workspace - 21C Museum Hotel St Louis (St. Louis)

Billiards - 21C Museum Hotel St Louis (St. Louis)

Dining - 21C Museum Hotel St Louis (St. Louis)

21C Museum Hotel St Louis stands in the heart of the city, offering travelers a refined experience with its indoor pool and fitness center. Guests can book a massage at the spa, play billiards at the bar, or start their day with a cooked-to-order breakfast at the coffee shop.

Wonderful

Popular amenities

Bar

Room options

Check availability for these dates

Tonight

Oct 23 - Oct 24

Tomorrow

Oct 24 - Oct 25

All rooms

1 bed

2 beds

Showing 10 of 10 rooms

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Room, 1 King Bed

Wonderful

Highlights

Soundproofed

Air conditioning

Heating

Flat-screen TV

Separate bedroom

Blackout drapes/curtains

Hair dryer

Private bathroom

309 sq ft
Sleeps 2
1 King Bed

Luxury Double Room, 2 Queen Beds

Wonderful

Highlights

Soundproofed

Air conditioning

Heating

Flat-screen TV

Separate bedroom

Blackout drapes/curtains

Hair dryer

Private bathroom

423 sq ft
Sleeps 4
2 Queen Beds

Room (Bunk Bed)

Very good

Highlights

Soundproofed

Air conditioning

Heating

Flat-screen TV

Separate bedroom

Blackout drapes/curtains

Hair dryer

Private bathroom

237 sq ft
1 bedroom
Sleeps 2
1 Twin Bunk Bed

Loft, 2 Queen Beds

Highlights

Soundproofed

Air conditioning

Heating

Flat-screen TV

Separate bedroom

Blackout drapes/curtains

Hair dryer

Private bathroom

431 sq ft
Sleeps 4
2 Queen Beds

Deluxe Room, Accessible (Accessible)

Highlights

Soundproofed

Air conditioning

Heating

Flat-screen TV

Separate bedroom

Blackout drapes/curtains

Hair dryer

Private bathroom

269 sq ft
Sleeps 2
1 King Bed

Suite, 1 King Bed (21C)

Highlights

Soundproofed

Air conditioning

Heating

Flat-screen TV

Separate bedroom

Blackout drapes/curtains

Separate bathtub and shower

Private bathroom

1119 sq ft
Sleeps 2
1 King Bed

Suite, 1 King Bed (Library)

Highlights

Soundproofed

Air conditioning

Heating

Flat-screen TV

Separate bedroom

Blackout drapes/curtains

Hair dryer

Private bathroom

732 sq ft
City view
Sleeps 2
1 King Bed

Luxury Suite, 1 King Bed

Highlights

Soundproofed

Air conditioning

Heating

Flat-screen TV

Separate bedroom

Blackout drapes/curtains

Separate bathtub and shower

Private bathroom

549 sq ft
Sleeps 2
1 King Bed

Deluxe Room, 1 Double Bed, Accessible

Highlights

Soundproofed

Air conditioning

Heating

Flat-screen TV

Separate bedroom

Blackout drapes/curtains

Hair dryer

Private bathroom

388 sq ft
Sleeps 4
1 Double Bed

Deluxe Suite, 1 Double Bed, Accessible

Highlights

Soundproofed

Air conditioning

Heating

Flat-screen TV

Separate bedroom

Blackout drapes/curtains

Hair dryer

Private bathroom

517 sq ft
Sleeps 2
1 Double Bed

About the neighborhood

Located in St. Louis, 21C Museum Hotel St Louis is in the city center. City Museum and Fox Theater are cultural highlights, and some of the area's notable landmarks include St. Louis Union Station and Gateway Arch. Looking to enjoy an event or a game? See what's going on at Busch Stadium or Enterprise Center.

Visit our St. Louis travel guide

1528 Locust street, St. Louis, MO, 63103

What's nearby

St. Louis Union Station - 6 min walk - 0.4 miles
Enterprise Center - 6 min walk - 0.4 miles
City Museum - 6 min walk - 0.4 miles
Busch Stadium - 14 min walk - 0.8 miles
Gateway Arch - 2 min drive - 1.1 miles

Getting around

8th and Pine Station - 13 min walk
St. Louis Gateway Station - 14 min walk
St. Louis Lambert Intl. Airport (STL) - 26 min drive

Restaurants

‪Medina Grill - ‬5 min walk
‪City Museum Rooftop Cafe - ‬5 min walk
‪White Knight Diner - ‬4 min walk
‪Budweiser Kiel Club - ‬6 min walk
‪Idol Wolf - ‬1 min walk

About this property

21C Museum Hotel St Louis

Luxury hotel near Enterprise Center

Located close to St. Louis Union Station and Busch Stadium, 21C Museum Hotel St Louis provides a coffee shop/cafe, dry cleaning/laundry services, and a bar. Treat yourself to a massage or other spa services. In addition to a gym and a business center, guests can connect to free in-room WiFi.

You'll also enjoy the following perks during your stay:

An indoor pool
Cooked-to-order breakfast (surcharge), valet parking (surcharge), and luggage storage
Meeting rooms, a banquet hall, and an elevator
Smoke-free premises, a billiards/pool table, and a vending machine
Guest reviews speak highly of the dining options, pool, and helpful staff

Room features

All 104 rooms include comforts such as laptop-friendly workspaces and air conditioning, as well as perks like free WiFi and desk chairs. Guest reviews highly rate the clean rooms at the property.

More amenities include:

Free toiletries and hair dryers
Flat-screen TVs with premium channels
Wardrobes/closets, heating, and daily housekeeping

Similar properties

Pet friendly
Free WiFi
Restaurant
Air conditioning

$101 nightly

Nov 23 - Nov 24

Total with taxes and fees

Property amenities

Internet

Available in all rooms: Free WiFi
Available in some public areas: Free WiFi

Parking and transportation

Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
A bar/lounge
A coffee shop/cafe
A restaurant

Things to do

Billiards/pool table
Gym
Indoor pool
Steam room

Family friendly

Indoor pool
Soundproofed rooms

Conveniences

24-hour front desk
ATM
Luggage storage
Vending machine

Guest services

Change of bedsheets (on request)
Change of towels on request
Concierge services
Dry cleaning/laundry service
Housekeeping (daily)

Business services

Business center
Meeting rooms

Spa

Massage
Spa services

Accessibility

If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
Area rugs in room
Braille/raised signage
Elevator (42 inch wide door)
Grab bar in shower (35 inches high)
Handrails in stairways (36 inches high)
Lever door handles
Magnifying mirror
Pool hoist on site
Stair-free path to entrance
Thin carpet in room
Tile flooring in room
Visual fire alarm
Well-lit path to entrance
Wheelchair accessible (may have limitations)
Wheelchair-accessible gym
Wheelchair-accessible lounge
Wheelchair-accessible path of travel
Wheelchair-accessible pool
Wheelchair-accessible public washroom
Wheelchair-accessible registration desk (36 inches high)
Wheelchair-accessible restaurant
Wheelchair-accessible spa
Wheelchairs on site

More

Banquet hall
Biodegradable coffee stirrers available
Biodegradable drinking straws available
No plastic coffee stirrers
No plastic drinking straws
No plastic soft drink bottles
No plastic water bottles
Reusable cups
Reusable tableware
Smoking not allowed

Room amenities

Bedroom

Bedsheets provided
Blackout drapes

Bathroom

Bathrobes
Free toiletries
Hair dryer
Shampoo
Soap
Toilet paper
Toothbrush and toothpaste (on request)
Towels provided

Entertainment

Flat-screen TV with premium digital channels

Food and drink

Espresso maker
Free bottled water
Limited room service

More

Air conditioning
Desk
Desk chair
Heating
Iron/ironing board
Laptop workspace
Phone
Safe
Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM

Late check-in subject to availability

Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Access methods

Staffed front desk

Pets

Pets allowed for an extra charge of USD 100 per accommodation, per stay

Service animals are welcome, and are exempt from fees

Welcoming dogs only

Children and extra beds

Children are welcome

Rollaway/extra beds are not available

Cribs (infant beds) are not available

Property payment types

Important information

Optional extras

Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
Valet parking fee: USD 50 per day (in/out privileges)
Pet fee: USD 100 per accommodation, per stay
Service animals are exempt from fees

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy

Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges

Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed

This property accepts credit cards; cash is not accepted

Safety features at this property include a smoke detector and outdoor lighting

We should mention

Reservations are required for massage services; reservations can be made by contacting the property prior to arrival, using the contact information on the booking confirmation

This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Property is also known as

21C Museum Hotel St Louis

21c Museum St Louis St Louis

21C Museum Hotel St Louis Hotel

21C Museum Hotel St Louis St. Louis

21C Museum Hotel St Louis Hotel St. Louis

21C Museum Hotel St Louis (Opening Spring 2023)

Frequently asked questions

Does 21C Museum Hotel St Louis have a pool?

Yes, this property has an indoor pool.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of Oct 23, 2025, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on Oct 31, 2025 start from $143.1, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Is 21C Museum Hotel St Louis pet-friendly?

Yes, dogs are allowed at this property. There's a fee of USD 100 per accommodation, per stay. Service animals are exempt from fees.

How much is parking at 21C Museum Hotel St Louis ?

Valet parking is available for USD 50 per day.

What time is check-in at 21C Museum Hotel St Louis ?

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM. Late check-in is available during limited hours.

What time is check-out at 21C Museum Hotel St Louis ?

Check-out is at 11:00 AM.

Where is 21C Museum Hotel St Louis located?

Located in Downtown West, this luxury hotel is within a 10-minute walk of Washington Avenue Historic District, City Museum, and Enterprise Center. St. Louis Union Station and America's Center Convention Complex are also within 15 minutes. 8th and Pine Station is 13 minutes by foot and Convention Center Station is 16 minutes.