21C Museum Hotel St Louis

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Luxury
4.5 star property
9.0

Wonderful

Luxury hotel near Enterprise Center

Close to City Museum and St. Louis Union Station, 21C Museum Hotel St Louis provides a coffee shop/cafe, dry cleaning/laundry services, and a bar. Treat yourself to a massage or other spa services. In addition to a gym and a business center, guests can connect to free in-room WiFi.

Popular amenities

  • Pet friendly
  • Free WiFi
  • Air conditioning

Room options

Available filters for rooms
Showing 10 of 10 rooms

View all photos for Deluxe Room, 1 King Bed

A hotel room with a large bed, a desk with a chair, a small table, and a lamp.

Deluxe Room, 1 King Bed

9.0 out of 10
Wonderful
(140 reviews)
  • 309 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

A hotel room with two beds, a large window, a modern ceiling light, and a view of a staircase.

Luxury Double Room, 2 Queen Beds

9.4 out of 10
Exceptional
(43 reviews)
  • 423 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room (Bunk Bed)

A hotel room with a bunk bed, a round table with a chair, a potted plant, and a colorful abstract painting on the wall.

Room (Bunk Bed)

8.6 out of 10
Excellent
(10 reviews)
  • 237 sq ft
  • Sleeps 2
  • 1 Twin Bunk Bed

View all photos for Loft, 2 Queen Beds

A hotel room with two beds, a large padded headboard, a flat-screen TV, a window with a city view, and a small side table with a plant.

Loft, 2 Queen Beds

7.4 out of 10
Good
(6 reviews)
  • 431 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Deluxe Room, Accessible (Accessible)

A hotel room with a large bed, a desk with a chair, a small table, and a lamp.

Deluxe Room, Accessible (Accessible)

10.0 out of 10
Exceptional
(1 review)
  • 269 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (21C)

A hotel room with a large bed, a desk, a chair, a nightstand, and a mirror.

Suite, 1 King Bed (21C)

  • 1119 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Library)

A hotel room with a large bed, a wooden headboard, a nightstand with a lamp, a green armchair, and a large painting on the wall.

Suite, 1 King Bed (Library)

  • City view
  • 732 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Suite, 1 King Bed

Room

Luxury Suite, 1 King Bed

9.4 out of 10
Exceptional
(3 reviews)
  • 549 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 Double Bed, Accessible

A hotel room with two beds, a sofa, a TV, and a large abstract painting.

Deluxe Room, 1 Double Bed, Accessible

  • 388 sq ft
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Suite, 1 Double Bed, Accessible

A hotel room with a large bed, a desk with a chair, a small table, and a lamp.

Deluxe Suite, 1 Double Bed, Accessible

  • 517 sq ft
  • Sleeps 2
  • 1 Double Bed

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About the neighborhood

Located in St. Louis, 21C Museum Hotel St Louis is in the city center. St. Louis Union Station and Gateway Arch are notable landmarks, and some of the area's popular attractions include St. Louis Zoo and Missouri Botanical Garden. Looking to enjoy an event or a game? See what's going on at Enterprise Center or Dome at America’s Center. Visit our St. Louis travel guide
Map
1528 Locust street, St. Louis, MO, 63103

What's nearby

  • The National Blues Museum in Saint Louis, Missouri.
    Washington Avenue Historic District
    2 min walk - 0.1 miles
  • A tightrope walker balancing on a wire between buildings.
    City Museum
    5 min walk - 0.3 miles
  • A historic building with a clock tower and red-roofed structures.
    St. Louis Union Station
    8 min walk - 0.4 miles
  • A cityscape with a prominent statue in the center, surrounded by various buildings and a large stadium.
    Enterprise Center
    8 min walk - 0.5 miles
  • St. Louis Aquarium at Union Station
    11 min walk - 0.6 miles

Getting around

  • 8th and Pine Station
    13 min walk
  • St. Louis Gateway Station
    14 min walk
  • St. Louis Lambert Intl. Airport (STL)
    24 min drive

Restaurants

  • Rosalita's Cantina
    6 min walk
  • Hair of the Dog
    7 min walk
  • Good Press
    1 min walk
  • Imo's Pizza Headquarters & Retail Store
    7 min walk
  • Medina Grill
    5 min walk

About this property

21C Museum Hotel St Louis

  • Luxury hotel near Enterprise Center
  • Close to City Museum and St. Louis Union Station, 21C Museum Hotel St Louis provides a coffee shop/cafe, dry cleaning/laundry services, and a bar. Treat yourself to a massage or other spa services. In addition to a gym and a business center, guests can connect to free in-room WiFi.
  • You'll also enjoy the following perks during your stay:
    • An indoor pool
    • Cooked-to-order breakfast (surcharge), valet parking (surcharge), and a vending machine
    • A 24-hour front desk, concierge services, and smoke-free premises
    • Luggage storage, meeting rooms, and ATM/banking services
    • Guest reviews speak highly of the dining options, pool, and helpful staff
  • Room features
  • All 104 rooms include comforts such as laptop-friendly workspaces and air conditioning, as well as perks like free WiFi and desk chairs. Guest reviews highly rate the clean rooms at the property.
  • More amenities include:
    • Free toiletries and hair dryers
    • Flat-screen TVs with premium channels
    • Wardrobes/closets, heating, and daily housekeeping

Awards and affiliations

  • Sustainability Certifications
  • This property is certified by this third-party sustainability certification scheme: Green Key Global. For more information on what this certification requires and verifies, please visit their website.

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Frequently asked questions

Does 21C Museum Hotel St Louis have a pool?

Yes, this property has an indoor pool.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of Oct 23, 2026, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on Nov 15, 2026 start from $173, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Is 21C Museum Hotel St Louis pet-friendly?

Yes, dogs are allowed at this property. There's a fee of USD 100 per accommodation, per stay. Service animals are exempt from fees.

How much is parking?

Valet parking is available for USD 55 per day.

What time is check-in at 21C Museum Hotel St Louis ?

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM. Late check-in is available during limited hours.

What time is check-out at 21C Museum Hotel St Louis ?

Check-out is at 11:00 AM.

Where is 21C Museum Hotel St Louis located?

Located in Downtown West, this luxury hotel is within a 10-minute walk of Washington Avenue Historic District, St. Louis Union Station, and City Museum. Enterprise Center and America's Center Convention Complex are also within 15 minutes. 8th and Pine Station is 13 minutes by foot and Convention Center Station is 15 minutes.

Can I cancel my reservation for free and receive a full refund?

Yes, this property offers free cancellation on select room rates, because flexibility matters! Please refer to the property cancellation policy on our site for more details about any exclusions or requirements.

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Reviews

21C Museum Hotel St Louis Reviews

9.0

Wonderful

9.2

Cleanliness

9.0

Amenities

9.0

Staff & service

9.2

Property conditions & facilities
Rating 10 - Excellent. 1502 out of 2134 reviews
Rating 8 - Good. 330 out of 2134 reviews
Rating 6 - Okay. 157 out of 2134 reviews
Rating 4 - Poor. 67 out of 2134 reviews
Rating 2 - Terrible. 78 out of 2134 reviews

Reviews

Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Unique and beautiful hotel. Staff is efficient and friendly.
Stayed 1 night in Oct 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Love this hotel. Great stay for our entire family.
Stayed 3 nights in Sep 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The staff was wonderful
Stayed 2 nights in Sep 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Room was clean, staff were helpful, Art was really neat. Also one of the nicest hotel gyms I’ve ever experienced. Very large pool and hot plus other spa accommodations. Overall really enjoyed our stay here and would definitely go back.
Stayed 2 nights in Sep 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Excellent hotel , friendly , loved all public area including the pool
Stayed 1 night in Sep 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Wonderful, fun place to stay! Staff was great. Clean and inviting with amazing art. And want to return!
Stayed 2 nights in Sep 2026
Verified review

8/10 Good

Liked: Cleanliness, staff & service, property conditions & facilities
Wonderful vibrant bar and restaurant scene. Location is walkable, but we had to use the valet parking which was an additional cost of $55 per day since the hotel did not have parking.
Stayed 2 nights in Oct 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Fun hotel. Nice restaurant. I did not use the pool. Good location. Front desk pleasant and helpful.
Stayed 2 nights in Sep 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Room clean. Staff friendly.
Stayed 2 nights in Sep 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beds were very comfy
Stayed 3 nights in Jul 2026
Verified review

8/10 Good

Liked: Staff & service, amenities
The hot tub and pool were great. The room was okay. The service at the restaurant and bar was great as well.
Stayed 1 night in Aug 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beautiful property. Everyone was so kind and so helpful. The art museum was very impressive for a free hotel museum! We unfortunately didn’t have time for the pool and spa areas! Also a great location.
Stayed 1 night in Sep 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beautiful hotel full of art. Bathrooms were nicely clean and renovated. Staff were very nice.
Stayed 1 night in Aug 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The property was clean, comfortable, and well maintained. The staff was friendly and helpful throughout my stay. I enjoyed the location and overall atmosphere. It was a pleasant experience, and I would consider staying here again.
Stayed 1 night in Aug 2026
Verified review

8/10 Good

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Pool and hot tub where great
Stayed 2 nights in Aug 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, property conditions & facilities
Friendly staff Helpful Courteous Great location for downtown activities
Stayed 1 night in Jul 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, property conditions & facilities
Cool hotel with a great restaurant and bar! Not much around there to speak of though.
Stayed 3 nights in Aug 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The hotel room was beautiful and very comfortable! The restaurant was amazing, museum was awesome and location was close to everything!
Stayed 1 night in Feb 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
A bit off the beating path, but well worth the walk or ride there. Unfortunately I was only there for a day, so missed out on many of the amenities. But will definitely book here again and take advantage of all they have to offer. P.S. The room are well kept, roomy, and comfortable.
Stayed 1 night in Sep 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Such an amazing place. We were on a road trip and needed a place where everything was there. This was it! We LOVED the pool and spa. And the art exhibit was beautiful!
Stayed 1 night in Aug 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
21C Museum St Louis is my favorite hotel. It is so vibrant. I love to swim and that YMCA pool built in the 1920s is gorgeous with hot tub and sauna. You get great coffee in the room, not the typical swill. The museum exhibits are thoughtfully curated and edgy. And they are featured in the old YMCA basketball court! Our room was lovely—the whole place is. This hotel is a destination for locals, it’s the place to be. Idol Wolf is the first outstanding restaurant experience I’ve had in a hotel.
Stayed 2 nights in Sep 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
very cool spot and i enjoyed my stay. Nice pool and hottub area too:)
Stayed 1 night in Jul 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean, Nice, comfortable.
Stayed 1 night in Aug 2026
Verified review

6/10 Okay

Liked: Cleanliness, staff & service
Disliked: Property conditions & facilities
Room was clean amenities were okay but the tub shower head and tap were not functioning properly. I was not able to turn it to tap fromshower head.
Stayed 2 nights in Sep 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great interesting hotel. The steam room and sauna and gym are an absolute bonus!
Stayed 1 night in Jul 2026