South America Vacations & Trips from $557
Book a Hotel + Flight or Car together to unlock savings
Top destinations in South America
São Paulo
Rio de Janeiro
Bogotá
Medellín
Cartagena
Gramado
Buenos Aires
Foz do Iguaçu
Atibaia
The Latest South America Vacation Packages
- Hotel Almirante Cartagena - Colombia
Sep 13 - Sep 18Hotel Almirante Cartagena - Colombia + Flight
Bocagrande5 nights4.5 star property8.4/10 - Very Good (1,000 reviews)Roundtrip • New York (EWR) - Cartagena (CTG)EWR - CTG • 1 stop CTG - EWR • 1 stop - Bora Bora Cartagena
Sep 13 - Sep 18Bora Bora Cartagena + Flight
Rosario Islands5 nights4.0 star property9.6/10 - Exceptional (52 reviews)"No hay palabras para describir la experiencia vivida. Empezando por el personal y atención VIP, realmente VIP. José, Damián, no los mencionó a todos porque no recuerdo sus nombres, pero todos fueron fantásticos, nos hicieron sentir como en casa. El lugar, la habitación, el servicio, hospitalidad, en general todo. Mis palabras no le hacen justicia al lugar. Solo puedo decir que es un 100% recomendado. Gina y Francis desde Puerto Rico, volvemos"Reviewed July 19, 2026Roundtrip • New York (EWR) - Cartagena (CTG)EWR - CTG • 1 stop CTG - EWR • 1 stop - Hotel Isla del Encanto
Sep 13 - Sep 18Hotel Isla del Encanto + Flight
Cartagena5 nights4.0 star property8.8/10 - Excellent (203 reviews)"Everything was great! Despite all the reviews, the food was AMAZING! The service great! The only thing i would make a note of was they have a bird named Coco and if she doesn’t like you, she’ll chase you! (First hand experience) but overall, 10/10 would recommend!!!"Reviewed May 18, 2026Roundtrip • New York (EWR) - Cartagena (CTG)EWR - CTG • 1 stop CTG - EWR • 1 stop - Hotel El Marqués By GEH Suites
Sep 27 - Oct 2Hotel El Marqués By GEH Suites + Flight
Cartagena Walled City5 nights3.5 star property9.0/10 - Wonderful (345 reviews)"The staff was friendly. The breakfast is good and the room was big and clean!"Reviewed May 21, 2026Roundtrip • New York (EWR) - Cartagena (CTG)JFK - CTG • 1 stop CTG - EWR • 1 stop - Devú
Sep 11 - Sep 15Devú + Flight
El Poblado4 nights5.0 star property9.8/10 - Exceptional (19 reviews)"I usually don't write reviews but this property is worthy of one. The apartment was absolutely gorgeous, and the service and location were amazing. If you're fine not having your bed made every day, then Devu can't be beat. If/when we return to Medellin we will definitely stay here again."Reviewed July 19, 2026Roundtrip • New York (EWR) - Medellín (MDE)EWR - MDE • 1 stop MDE - EWR • 1 stop
Discover the most popular places to visit in South America
South America Hotel Deals
Holiday Inn Lima Airport by IHG
Holiday Inn Lima Airport by IHG
Wyndham Costa Del Sol Lima Airport
Wyndham Costa Del Sol Lima Airport
Frequently Asked Questions
How much does a South America vacation package cost?
Starting from as little as $557, you can build your own South America package. Simply bundle flights, hotels and car rentals and be rewarded with discounts.
How do I get a cheap travel package to South America?
Our South America vacation packages offer plenty of savings for the savvy explorer. For the best deal, simply combine your hotel, flights and extras (such as activities) into a handy package. But bargain prices are just the beginning of your next unforgettable adventure. When you book with Expedia, and you'll have over 550 air carriers and 1,000,000 properties worldwide to choose from. No matter your style, there's a package here just for you.
How far in advance should I book my South America vacation?
While not all air carriers release tickets early, you can usually look up international flights on Expedia up to 12 months in advance. This is when you can bag some fantastic deals. If you're booking last minute, you could still be in luck. Sometimes the lowest prices emerge just weeks before departure.
What does an Expedia South America travel package include?
Car rentals, hotels and flights — we bring you the very best deals. All you have to do is decide on your ideal combination. After you've made your booking, you can add on the exciting stuff like experiences and tours. Our travel packages make it easy to craft an unforgettable South America getaway.
What should I know before booking a South America travel package?
So many places to go, so many things to see and do. With a package, you can cross more of them off your list. Combine your flights, rental cars and hotels and see how much you save.
Can I choose my airline with a South America Expedia vacation package?
Expedia offers access to more than 550 airline partners worldwide, so you certainly can. Simply pick your favorite carrier and craft your ideal South America getaway.
Does Expedia offer Book Now, Pay Later South America vacation packages?
Pay the full price for your package booking upfront or split it into multiple installments — it's your call. Every traveler has their own set of financial circumstances. It's for that reason Expedia has teamed up with online lender Affirm to provide a Book Now, Pay Later option for all vacation packages.
If I'm not able to travel, can I cancel my South America vacation package?
If your vacation plans in South America have changed, it's a relief to know that you can cancel your booking. If you booked less than 24 hours ago, you may be eligible for a refund. If your booking is older than that, your hotel, airline or car rental company may charge a cancellation fee. To find out more, visit our Customer Service Portal.
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Things to do in South America
Explore the vibrant culture and stunning landscapes of South America through unforgettable tours. Join group adventures to iconic destinations like Machu Picchu or the Amazon rainforest, where outdoor experiences abound. Discover the best tours tailored to your interests, from thrilling hikes to cultural immersions. Whether you seek adrenaline or relaxation, South America offers a diverse range of activities to make your vacation truly memorable.
Shopping
Experience the vibrant shopping scene in South America at 24 Hours Street, a lively shopping mall with entertainment and family-friendly options. For unique finds, visit Florida Street, a popular store, or immerse yourself in the local culture at San Pedro Market, a bustling public market.
Recreation
Allianz Parque offers a vibrant atmosphere with sports events and activities, perfect for fitness enthusiasts. For a celestial experience, visit the Tatacoa Astronomical Observatory, where family-friendly entertainment meets stargazing. Enjoy the lush landscapes at Karibana Golf Club, a golfer's paradise surrounded by stunning outdoor scenery.
Adventure
Experience the thrill of racing at Interlagos Race Track, where high-speed motorsport meets adrenaline. Enjoy water slides and wave pools at Beach Park Water Park, perfect for family fun. For winter sports enthusiasts, Catedral Alta Patagonia offers stunning ski slopes against breathtaking mountain backdrops.
Nightlife
South America's nightlife is vibrant and diverse. Enjoy a refreshing brew at Kunstmann Brewery, where the romantic atmosphere sets the mood. For a lively night out, dance at Villa Boemia nightclub, embracing the energetic city vibes. Experience culture at Santa Casa Historic Cultural Center, a hub for entertainment and art.
Find the best attractions in South America
Explore the stunning beaches, historic churches, and vibrant urban parks that South America has to offer. Whether you're seeking cultural experiences, outdoor adventures, or a relaxing beach getaway, there's something for every traveler. Don't miss out on discovering the rich heritage and natural beauty that this diverse continent presents as you plan your unforgettable vacation.
- Paulista Avenue: Experience the vibrant heart of São Paulo as you stroll along Paulista Avenue, a bustling street lined with cultural institutions, shops, and cafes. This iconic avenue showcases the city's dynamic energy, offering a mix of contemporary art, lively street performances, and a unique urban atmosphere.
- Beto Carrero World: Dive into a world of fun at Beto Carrero World, one of the largest theme parks in Latin America. With thrilling rides, entertaining shows, and attractions for all ages, it's the perfect destination for families looking for adventure and excitement.
- Copacabana Beach: Relax on the stunning shores of Copacabana Beach, where sun, sand, and surf meet. Enjoy the lively beach culture, partake in water sports, or sip a refreshing coconut water while taking in breathtaking ocean views.
Best time to go to South America
The best time to visit South America can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in South America falls in February, when visitor numbers are average and weather is mostly sunny with light rain. The coolest average temperature in South America falls in July, visitor numbers are average and weather is mostly sunny with no rain.
Tips to save on your trip to South America
- Take advantage of package deals on Expedia and combine flights, hotels, or car rentals for a convenient and cost-effective trip to South America.
- Consider traveling during the off-peak season (typically May and September to October) for more affordable package holidays to South America.
- Use the Price per traveler filter on Expedia to find a package deal that suits your budget.
- Check the VIP Access properties filter to discover outstanding hotels with added member perks at select properties.