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21C Museum Hotel St Louis

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Luxury
4.5 star property
9.0

Wonderful

Luxury hotel near Enterprise Center

Located close to St. Louis Union Station and Busch Stadium, 21C Museum Hotel St Louis provides a coffee shop/cafe, dry cleaning/laundry services, and a bar. Treat yourself to a massage or other spa services. In addition to a gym and a business center, guests can connect to free in-room WiFi.

Popular amenities

  • Pet friendly
  • Free WiFi
  • Air conditioning

Room options

Available filters for rooms
Showing 10 of 10 rooms

View all photos for Deluxe Room, 1 King Bed

A hotel room with a large bed, a desk with a chair, a small table, and a lamp.

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(126 reviews)
  • 309 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Luxury Double Room, 2 Queen Beds

A hotel room with two beds, a large window, a modern ceiling light, and a view of a staircase.

Luxury Double Room, 2 Queen Beds

9.4 out of 10
Exceptional
(40 reviews)
  • 423 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds
  • Free WiFi

View all photos for Room (Bunk Bed)

A hotel room with a bunk bed, a round table with a chair, a potted plant, and a colorful abstract painting on the wall.

Room (Bunk Bed)

8.6 out of 10
Excellent
(9 reviews)
  • 237 sq ft
  • Sleeps 2
  • 1 Twin Bunk Bed
  • Free WiFi

View all photos for Loft, 2 Queen Beds

A hotel room with two beds, a large padded headboard, a flat-screen TV, a window with a city view, and a small side table with a plant.

Loft, 2 Queen Beds

9.0 out of 10
Wonderful
(2 reviews)
  • 431 sq ft
  • Sleeps 4
  • 2 Queen Beds
  • Free WiFi

View all photos for Deluxe Room, Accessible (Accessible)

A hotel room with a large bed, a desk with a chair, a small table, and a lamp.

Deluxe Room, Accessible (Accessible)

10.0 out of 10
Exceptional
(1 review)
  • 269 sq ft
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Suite, 1 King Bed (21C)

A hotel room with a large bed, a desk, a chair, a nightstand, and a mirror.

Suite, 1 King Bed (21C)

  • 1119 sq ft
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Suite, 1 King Bed (Library)

A hotel room with a large bed, a wooden headboard, a nightstand with a lamp, a green armchair, and a large painting on the wall.

Suite, 1 King Bed (Library)

  • City view
  • 732 sq ft
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed | In-room safe, desk, laptop workspace, blackout drapes

Luxury Suite, 1 King Bed

9.4 out of 10
Exceptional
(3 reviews)
  • 549 sq ft
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Deluxe Room, 1 Double Bed, Accessible

A hotel room with two beds, a sofa, a TV, and a large abstract painting.

Deluxe Room, 1 Double Bed, Accessible

  • 388 sq ft
  • Sleeps 4
  • 1 Double Bed
  • Free WiFi

View all photos for Deluxe Suite, 1 Double Bed, Accessible

A hotel room with a large bed, a desk with a chair, a small table, and a lamp.

Deluxe Suite, 1 Double Bed, Accessible

  • 517 sq ft
  • Sleeps 2
  • 1 Double Bed
  • Free WiFi

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Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

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  • Pet friendly
  • Free WiFi
  • Restaurant
  • Air conditioning
8.6 out of 10, Excellent, 1,343 reviews
$126 nightly
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Sep 13 - Sep 14
Total with taxes and fees
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About the neighborhood

Located in St. Louis, 21C Museum Hotel St Louis is in the city center. St. Louis Union Station and Gateway Arch are notable landmarks, and the area's natural beauty can be seen at Mississippi River and Forest Park. Check out an event or a game at Busch Stadium, and consider making time for St. Louis Zoo, a top attraction not to be missed. Visit our St. Louis travel guide
Map
1528 Locust street, St. Louis, MO, 63103

What's nearby

  • A city street with a red car, a blue fire hydrant, and a building with a spire.
    Washington Avenue Historic District
    2 min walk - 0.1 miles
  • A tightrope walker balancing on a wire between buildings.
    City Museum
    5 min walk - 0.3 miles
  • A historic building with a clock tower and red-roofed structures.
    St. Louis Union Station
    8 min walk - 0.4 miles
  • A cityscape with a prominent statue in the center, surrounded by various buildings and a large stadium.
    Enterprise Center
    8 min walk - 0.5 miles
  • St. Louis Aquarium at Union Station
    11 min walk - 0.6 miles

Getting around

  • 8th and Pine Station
    13 min walk
  • St. Louis Gateway Station
    14 min walk
  • St. Louis Lambert Intl. Airport (STL)
    24 min drive

Restaurants

  • Rosalita's Cantina
    6 min walk
  • Hair of the Dog
    7 min walk
  • Imo's Pizza Headquarters & Retail Store
    7 min walk
  • Medina Grill
    5 min walk
  • Good Press
    1 min walk

About this property

21C Museum Hotel St Louis

  • Luxury hotel near Enterprise Center
  • Located close to St. Louis Union Station and Busch Stadium, 21C Museum Hotel St Louis provides a coffee shop/cafe, dry cleaning/laundry services, and a bar. Treat yourself to a massage or other spa services. In addition to a gym and a business center, guests can connect to free in-room WiFi.
  • You'll also enjoy the following perks during your stay:
    • An indoor pool
    • Cooked-to-order breakfast (surcharge), valet parking (surcharge), and a vending machine
    • Luggage storage, a banquet hall, and concierge services
    • ATM/banking services, meeting rooms, and smoke-free premises
    • Guest reviews speak highly of the dining options, pool, and helpful staff
  • Room features
  • All 104 rooms include comforts such as laptop-friendly workspaces and air conditioning, as well as perks like free WiFi and desk chairs. Guest reviews highly rate the clean rooms at the property.
  • More amenities include:
    • Free toiletries and hair dryers
    • Flat-screen TVs with premium channels
    • Wardrobes/closets, heating, and daily housekeeping

Awards and affiliations

  • Sustainability Certifications
  • This property is certified by this third-party sustainability certification scheme: Green Key Global. For more information on what this certification requires and verifies, please visit their website.

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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 55 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business center
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Non-plastic coffee stirrers available
  • Non-plastic drinking straws available
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets allowed for an extra charge of USD 100 per accommodation, per stay
Service animals are welcome, and are exempt from fees
Welcoming dogs only

Children and extra beds

Children are welcome
Rollaway/extra beds are not available
Cribs (infant beds) are not available

Property payment types

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Service fee: USD 5 per accommodation, per stay

We have included all charges provided to us by the property.

Optional extras

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 55 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher, a smoke detector, and outdoor lighting

We should mention

Reservations are required for massage services; reservations can be made by contacting the property prior to arrival, using the contact information on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Frequently asked questions

Does 21C Museum Hotel St Louis have a pool?

Yes, this property has an indoor pool.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of Aug 28, 2026, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on Sep 20, 2026 start from $173, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Is 21C Museum Hotel St Louis pet-friendly?

Yes, dogs are allowed at this property. There's a fee of USD 100 per accommodation, per stay. Service animals are exempt from fees.

How much is parking?

Valet parking is available for USD 55 per day.

What time is check-in at 21C Museum Hotel St Louis ?

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM. Late check-in is available during limited hours.

What time is check-out at 21C Museum Hotel St Louis ?

Check-out is at 11:00 AM.

Where is 21C Museum Hotel St Louis located?

Located in Downtown West, this luxury hotel is within a 10-minute walk of Washington Avenue Historic District, St. Louis Union Station, and City Museum. Enterprise Center and America's Center Convention Complex are also within 15 minutes. 8th and Pine Station is 13 minutes by foot and Convention Center Station is 15 minutes.

Can I cancel my reservation for free and receive a full refund?

Yes, this property offers free cancellation on select room rates, because flexibility matters! Please refer to the property cancellation policy on our site for more details about any exclusions or requirements.

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