If the younger family members are getting fidgety, take them to New Childrens Museum. With plenty of interactive displays and exhibits, this attraction makes learning fun.
This interactive exhibit for kids in Downtown San Diego is well-liked by travelers, so make a spot for it on your schedule. However, don't end your sightseeing there. There are many more attractions ready for you to enjoy after New Children's Museum. San Diego Zoo, Balboa Park, and University of San Diego are close by.