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Discover 8,483 Serra Mesa hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Wyndham San Diego Bayside
Exterior
Wyndham San Diego Bayside
4.0 star property
8.2 out of 10, Very Good, 5,932 reviews
"Great location with ocean views."
The price is $178
$200 total
includes taxes & fees
Jun 16 - Jun 17
Wyndham San Diego Bayside
Paradise Point Resort & Spa
Aerial view
Paradise Point Resort & Spa
4.0 star property
8.4 out of 10, Very Good, 1,834 reviews
"Great Place … really good food!"
The price is $283
$364 total
includes taxes & fees
Jun 11 - Jun 12
Paradise Point Resort & Spa
Wyndham Garden San Diego Near SeaWorld
Lobby
Wyndham Garden San Diego Near SeaWorld
3.0 star property
7.2 out of 10, Good, 2,739 reviews
"A friendly gentleman immediately greeted me upon entering the lobby. I booked and checked in online so receiving our room key and parking pass was quick. He provided clear direction to our building and room. The room was clean, updated, and smelled clean. Towels, linens, and the room was clean."
The price is $139
$157 total
includes taxes & fees
Jun 9 - Jun 10
Wyndham Garden San Diego Near SeaWorld
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The Dana on Mission Bay
Aerial view
The Dana on Mission Bay
3.5 star property
8.8 out of 10, Excellent, 2,544 reviews
"this place was so amazing and convenient. the service upon arrival was on point as well. definitely booking here again!"
The price is $179
$202 total
includes taxes & fees
Jun 12 - Jun 13
The Dana on Mission Bay
Manchester Grand Hyatt San Diego
Hypo-allergenic bedding, in-room safe, desk, iron/ironing board
Manchester Grand Hyatt San Diego
4.0 star property
9.0 out of 10, Wonderful, 3,235 reviews
"I was there for a conference and the property was clean and the staff was very helpful. The bathroom in my room was clean but the tub is small and the shower was a little quirky so not a 5 star. Would stay there again and recommend."
The price is $219
$294 total
includes taxes & fees
Jul 1 - Jul 2
Manchester Grand Hyatt San Diego
Omni San Diego Hotel
Exterior
Omni San Diego Hotel
4.0 star property
9.0 out of 10, Wonderful, 1,893 reviews
"We always stay Omni San Diego and house keeping is always good, but this time bathroom had hairs in tub and sink and floor… and 2nd day, house keeping didn’t check/clean coffee maker so we didn’t have any coffee cups nor tea, sugar, no refill on keurig cups. No plastic bag in ice bucket. Hairs again in sink, on floor & toilet… at least shower curtain was clean which is always plus at Omni. (Many hotel’s shower curtain stink and moldy, but never Omni!) "
The price is $207
$268 total
includes taxes & fees
Jul 1 - Jul 2
Omni San Diego Hotel
Sheraton San Diego Hotel and Marina
3 outdoor pools, open 7:00 AM to 10:00 PM, pool umbrellas, sun loungers
Sheraton San Diego Hotel and Marina
4.0 star property
7.8 out of 10, Good, 2,294 reviews
"Safe, nice area. did not like not many dinner / breakfast options around"
The price is $183
$235 total
includes taxes & fees
Jun 16 - Jun 17
Sheraton San Diego Hotel and Marina
Bay Club Hotel & Marina
Exterior
Bay Club Hotel & Marina
3.5 star property
9.0 out of 10, Wonderful, 1,972 reviews
"OUR STAY WAS GREAT. CLOSE TO THINGS WE WANTED TO DO. SUPER COMFORTABLE BED. THANKS!"
The price is $179
$201 total
includes taxes & fees
Jul 7 - Jul 8
Bay Club Hotel & Marina
DoubleTree by Hilton San Diego - Hotel Circle
Terrace/patio
DoubleTree by Hilton San Diego - Hotel Circle
4.0 star property
7.4 out of 10, Good, 1,563 reviews
"Staff was exceptionally helpful and accommodating "
The price is $149
$168 total
includes taxes & fees
Jun 9 - Jun 10
DoubleTree by Hilton San Diego - Hotel Circle
Hard Rock Hotel San Diego
Property amenity
Hard Rock Hotel San Diego
4.0 star property
8.8 out of 10, Excellent, 2,159 reviews
"Had a great stay. Hotel was really clean and comfortable. Perfect location right next to Gas Lamp Quarter "
The price is $242
$316 total
includes taxes & fees
Jul 1 - Jul 2
Hard Rock Hotel San Diego
California Suites Hotel
Pool
California Suites Hotel
2.0 star property
7.0 out of 10, Good, 1,367 reviews
"The room was decent and room was clean and in good condition. I like that there was a fridge and microwave available. The AC was in good condition. The pool and jacuzzi were accessible. "
The price is $101
$114 total
includes taxes & fees
Jun 9 - Jun 10
California Suites Hotel
San Diego Mission Bay Resort
Outdoor pool, open 9:00 AM to 9:00 PM, cabanas (surcharge)
San Diego Mission Bay Resort
4.0 star property
8.2 out of 10, Very Good, 1,026 reviews
"Expensive for what it was."
The price is $266
$344 total
includes taxes & fees
Jun 12 - Jun 13
San Diego Mission Bay Resort
Mission Bay Inn San Diego
Outdoor pool
Mission Bay Inn San Diego
2.5 star property
7.4 out of 10, Good, 1,023 reviews
"The property was close to a lot of things. It was also near the beaches. I like that they had a good breakfast. The staff were super helpful."
The price is $114
$129 total
includes taxes & fees
Jun 10 - Jun 11
Mission Bay Inn San Diego
Hilton San Diego Bayfront
Outdoor pool, sun loungers
Hilton San Diego Bayfront
4.0 star property
8.4 out of 10, Very Good, 1,525 reviews
"A lot of construction in the area"
The price is $184
$255 total
includes taxes & fees
Jul 1 - Jul 2
Hilton San Diego Bayfront
Marriott Marquis San Diego Marina
Premium bedding, in-room safe, desk, blackout drapes
Marriott Marquis San Diego Marina
4.0 star property
8.8 out of 10, Excellent, 1,848 reviews
"Check in was a long line. Took too long. Property was very nice and great location."
The price is $195
$255 total
includes taxes & fees
Jul 1 - Jul 2
Marriott Marquis San Diego Marina
Best Western Plus Island Palms Hotel & Marina
2 outdoor pools, sun loungers
Best Western Plus Island Palms Hotel & Marina
3.0 star property
8.8 out of 10, Excellent, 1,599 reviews
"Nice place "
The price is $190
$214 total
includes taxes & fees
Jun 24 - Jun 25
Best Western Plus Island Palms Hotel & Marina
Legacy Resort Hotel & Spa
Lobby
Legacy Resort Hotel & Spa
4.0 star property
9.0 out of 10, Wonderful, 2,881 reviews
"Staff service was good. Not likely friendly."
The price is $187
$211 total
includes taxes & fees
Jun 24 - Jun 25
Legacy Resort Hotel & Spa
Days Inn by Wyndham San Diego Hotel Circle
Outdoor pool, a heated pool
Days Inn by Wyndham San Diego Hotel Circle
3.0 star property
7.8 out of 10, Good, 1,918 reviews
"Good sized clean room. Beds very comfortable. Staff friendly. There was some algae growing along the above water areas of the pool. Jets on spa pretty powerful, it can splash on your face easily."
The price is $139
$156 total
includes taxes & fees
Jun 9 - Jun 10
Days Inn by Wyndham San Diego Hotel Circle
Hampton Inn San Diego-Downtown
Outdoor pool, pool umbrellas, sun loungers
Hampton Inn San Diego-Downtown
2.5 star property
8.2 out of 10, Very Good, 1,426 reviews
"While not my first option it turned out to be an exceptional experience. Well run at all levels. "
The price is $169
$191 total
includes taxes & fees
Jun 13 - Jun 14
Hampton Inn San Diego-Downtown
The Wayfarer San Diego
Outdoor pool, a heated pool
The Wayfarer San Diego
4.0 star property
9.2 out of 10, Wonderful, 1,090 reviews
"Absolutely phenomenal experience"
The price is $319
$360 total
includes taxes & fees
Jun 9 - Jun 10
The Wayfarer San Diego
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See all available properties in Serra Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighborhoods around Serra Mesa

Hotels in top San Diego neighborhoods Learn more about Serra Mesa
US Grant Hotel

Downtown San Diego

2 out of top 10 points of interest in this area
4.5/5(8,497 area reviews)

From historic streets, waterfront parks and baseball, to performing arts venues, nightlife zones and art and maritime museums, this is the cultural hub of San Diego.

Find hotels in Downtown San Diego

Serra Mesa Travel Info

Number of reviews
41,714
Location
San Diego, United States of America
Similar neighborhoods
Central San Diego, Mission Valley West and Midway District
Accommodation
8,483 hotels
Known landmarks
Boomers San Diego, Diversionary Theatre and Snapdragon Stadium
Hotels with golf
Courtyard by Marriott San Diego Central, Four Points by Sheraton San Diego and Extended Stay America Suites San Diego Fashion Valley
Lowest price
$101
Highest price
$319

Frequently asked questions

What's it like in Serra Mesa?

Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighborhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.

Where is the best place to stay in Serra Mesa?

For your stay in Serra Mesa, Cozy 2 bedroom unit with pool is one of the top choices based on our traveler data. Other good choices for your stay in the area include Centrally Located San Diego Condo w/Hot Tub & Pool and Central location - 3br/2ba. Stay weekly. Clean, safe, quiet. .

How many hotels will I be able to find in the Serra Mesa area?

Expedia has 28 hotels and other accommodations in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.

If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?

Yes, you'll find most hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Add your dates and click on "Search", then filter by "fully refundable" to view the top deals on offer in Serra Mesa.

Where can I learn more about changing or cancelling my trip to Serra Mesa?

For more information about picking new dates or cancelling your trip to Serra Mesa, click here.

What can I see and do in this San Diego neighborhood?

Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.

Recent reviews of Serra Mesa hotels

Bay Club Hotel & Marina

Bay Club Hotel & Marina

5/5 Excellent
"OUR STAY WAS GREAT. CLOSE TO THINGS WE WANTED TO DO. SUPER COMFORTABLE BED. THANKS!"
A verified traveler stayed at Bay Club Hotel & Marina
Posted 16 hours ago
Bay Club Hotel & Marina