If you're craving some mental stimulation, make a trip to Museum of Oaxacan Culture. Whether it's history, culture or beliefs, you'll find lots of thought-provoking displays to keep your mind active here.
This collection of historical artifacts is located in Oaxaca Centro. Once you've seen all you can at Museum of Oaxacan Culture, pay a visit to nearby Zocalo Square, Church of Santo Domingo de Guzman, and Auditorio Guelaguetza.